Sarah Kargbo-Hill, PhD (she/her)

Postdoc at NINDS/NIH, In-coming Assistant Professor of MCDB at University of Michigan, interested in how neurons adapt to survive stress and disease

[Ubadah Sabbagh @neubadah]

One of my favorite things is that at least once a month a stranger will email me expressing how helpful they found this guide. It's been read 20k+ times since I've published it, and it's time to share it again.
https://t.co/kM7NkQeZUf

[Oscar Wilkins @OscarWilkins16]

New BioRxiv paper on using cryptic splicing to unlock precision gene therapy activation for ALS, FTD & other TDP-opathies! Key contributions @MaxZYJChien Josette Wlaschin +many others from @ClaireLePichon @ule_lab @FrattaLab labs and more. A thread 🧵 1/13 https://t.co/CbuBmZvMpL

[Sarah Kargbo-Hill, PhD (she/her) @KargboHill]

@titassengupta2 @UMich @UMich_MCDB Thank you Titas!

[Sarah Kargbo-Hill, PhD (she/her) @KargboHill]

I am thrilled to announce that I will be joining University of Michigan’s MCDB department as an Assistant professor starting in January 2024! @UMich, @UMich_MCDB, #NewPI #AcademicLife #STEM A thread 1/5

[Sarah Kargbo-Hill, PhD (she/her) @KargboHill]

@HaoLab_GWU @UMich @UMich_MCDB Thank you, Ling!

[Sarah Kargbo-Hill, PhD (she/her) @KargboHill]

If you are passionate about neuroscience, neurodegeneration, RNA splicing, DNA methylation, ALS/FTD, TDP-43, or related areas, consider joining us! We welcome applications at all levels. Contact me at [email protected] #ResearchOpportunities, 5/5

[Sarah Kargbo-Hill, PhD (she/her) @KargboHill]

The Kargbo-Hill Lab will study how neurons regulate gene expression through RNA splicing and DNA demethylation to respond to changes in environment or disease, using iPSC-derived neurons, C. elegans, and 'omics approaches. #Neuroscience, #Neurodegeneration #ALS #TDP43 #RNA 4/5

[Sisi Yang @SisiYang10]

The second main project from my graduate school has finally been published! In this paper we performed forward genetic screen and identified an active zone protein CLA-1 regulates sorting of autophagy protein ATG-9, which shows different phenotype with synaptic vesicle proteins.

[AL Brown @annaleighbrown2]

In the interest of trying to make science more accessible (e.g. writing something my family will understand) I wrote a lay summary of our recent work on the UNC13A cryptic exon - check it out here! https://t.co/7wy9bNzS5e

[M W @Michael_E_Ward_]

New pre-print from our group, in which we discovered that mis-spliced RNAs sometimes encode de novo proteins in ALS and FTD. Great collab with Pietro Fratta's and Len Petrucelli's teams! https://t.co/kQ8eJN07GF

[FrattaLab @FrattaLab]

Yes, many cryptic exons cause RNA degradation, but our work with @Michael_E_Ward_ and Len Petrucelli shows some are translated - with important implications for the immune response, pathogenesis and biomarkers of ALS/FTD.
@annaleighbrown2 @OscarWilkins16 https://t.co/rz3vdxgWTk

[nature @Nature]

How well connected are the world’s leading science cities? https://t.co/F2j8k9Cbpv

[M W @Michael_E_Ward_]

This is huge! https://t.co/XhwPiCZd9l

[Anne Carpenter, PhD @DrAnneCarpenter]

Told my girls that @CarolynBertozzi won the Nobel prize and that it’s extra cool because usually men win it.

8yo: “That’s weird because most people don’t really remember the men who got it, just the women. Like Marie Curie… I mean, I can’t even name any men who won.” 😂

[Hunter Wapman @hneutr]

1/ New paper! https://t.co/E1iAwyqr3g with @_szhang @aaronclauset @DanLarremore.

🎓 We analyzed all 295K tenure-track faculty at US PhD-granting universities in 10,612 departments over 10 years to quantify hierarchy and dynamics in US faculty hiring and retention.

🦥 A summary:

[FrattaLab @FrattaLab]

Out @Nature!
TDP-43 path induces crucial synaptic UNC13A mis-splicing and loss. ALS risk SNPs exacerbate this, worsening disease progression.
We uncover the elusive UNC13A risk SNP mechanism, suggesting patients may do better if we correct UNC13A splicing.
https://t.co/uI5avgfOAS

[M W @Michael_E_Ward_]

I'm thrilled to share our new pre-print, a collaborative effort with Andre Nussenzweig's lab, in which we show that neurons exhibit a surprising amount of ssDNA repair specifically at enhancers. https://t.co/CEW80vfY6H

[Sarah Kargbo-Hill, PhD (she/her) @KargboHill]

Love the logo!

[Dr. Andrea Stavoe, PhD 🔬🧠 @AKHStavoe]

The Stavoe Lab has a logo and a website (https://t.co/1gaIDecpV3)! Next steps: people and equipment...