David Breslow lab

Cilia, centrioles, signaling & cell cycle - Yale University - Molecular, Cellular & Developmental Biology

[Reiter Lab @ReiterLab]

Please come join me in Washington, DC August 2-6th for the FASEB SRC on Cilia and Centrosomes meeting! Over 40 talks will be selected from abstracts. We are also excited to launch our first North American Ciliopathy Summit, held at the same venue on Aug 2. https://t.co/qvm1I0NosK

[Biomedical Picture of the Day BPoD @BPoD_s]

Imaging-based CRISPR genome screening allows effects of cell-regulating molecules & modifications to be revealed in live & fixed cells – applied here to frog embryo cilia

📹 Jingbo Sun et al @DavidBreslowLab @Yale in @Dev_Cell
➡️ https://t.co/DAPis1jjfe

[David Breslow lab @DavidBreslowLab]

Lots of potential for future ciliary (and non-ciliary) screening applications. Great work by all authors, especially postdoc Jingbo Sun. And great collaboration with the Khokha lab!

[David Breslow lab @DavidBreslowLab]

Ever wanted to do a genome-scale CRISPR screen for a microscopy-based phenotype? Pooled CRISPR screens are amazing, but hard to combine with microscopy... Excited to share a technology platform for such imaging screens and applications to primary cilia... https://t.co/mjxZ9flsvm

[David Breslow lab @DavidBreslowLab]

SMIM27/TZMP1 KO cells don't form cilia. TZMP1 localizes to the transition and by IP/MS is part of the MKS complex at the transition zone. With Mustafa Khokha, we find conserved roles in ciliary function in Xenopus embryos.

[Developmental Cell @Dev_Cell]

Online now: A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology https://t.co/MOKt7frjoN

[David Breslow lab @DavidBreslowLab]

Great work by all authors, especially first Breslow lab grad student Shane Elliott. And thanks also to excellent collaborations at Yale with labs of Angelique Bordey and Tony Koleske

[David Breslow lab @DavidBreslowLab]

Excited to share our latest work on a new cilia disassembly pathway & a link between this pathway and the neurological disorder focal cortical dysplasia: https://t.co/39JHWrtcCL
Summary: From a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...

[David Breslow lab @DavidBreslowLab]

3) it is noteworthy that a GOF CRISPRa screen was able to uncover a connection to a disorder caused by somatic activating mutations; possibly CRISPRa screening may be broadly useful for studying such diseases caused by somatic mutations ...

[Yale MCDB @MCDB_Yale]

Calling all biologists! 📢

Is your research at the cutting edge of synthetic biology, genomics or AI?

Apply to join our team of world-class scholars!🔬🦠

Tenure-track Assistant Professor
Anticipated Start Date: July 1, 2026

#hiring #genomics #biology
https://t.co/HHDdpRQwZH

[Prof. Akiko Iwasaki @VirusesImmunity]

NIH indirect costs fund the backbone of research: maintaining labs, ensuring safety, and supporting admin work. These are essential for groundbreaking discoveries. Drastic cuts to NIH indirect rates are detrimental to academic biomedical research.

[Mick lab @MickLab]

Proud to share our work by a fantastic team, spear-headed by PhD student @Kainerox with major contributions by #xenopus expert @RosiFeistel.

We developed an improved iAPEX-based #ProximityLabeling method for #massspec based subcellular #proteomics.

https://t.co/0jDlrlkK7M