Kevin Dong

Harvard PhD '25 @GygiLab
Previous Moonshot Fellow @apollohealthvc
Passionate about finding ways to extend healthspan and promote molecular resilience

[Alex Bott @alexjbott]

Happy to share our new preprint from @RutterLab. To understand how genes are controlled, we developed a method we call TRoUT-FISH, using CRISPR + RNA-FISH. We found that glycolytic gene expression is fine-tuned by lineage specifying transcription factors.

https://t.co/U3Hi1Ovozn

[James Zou @james_y_zou]

Today in @NatureMedicine we report that AI can predict 130 diseases from 1 night of sleep🛌

We trained a foundation model (#SleepFM) on 585K hours of sleep recordings from 65K people—brain, heart, muscle & breathing signals combined.

AI learns the language of sleep🧵

[Travis Fleming @tjflemin]

Stem cell-like states confer poor outcomes in blood cancer—but what mechanisms drive this and how can they be therapeutically targeted? In our new preprint, we show how a single TF represses one enhancer to maintain a subset of high-risk leukemias: 🧵👇
https://t.co/JS8yUt0hCJ

[Rapé Lab @RapeLab]

Huge shoutout to Chris Lima's lab @MSKCancerCenter @HHMINEWS for capturing basically the entire ubiquitylation cascade via cryo-EM!!! Congratulations to this creative tour-de-force that follows ubiquitin's path towards a substrate.

https://t.co/tMqLuAIGvR

[Nature Cell Biology @NatureCellBio]

☕️In this issue: Kubicek & co report a method for multicolour tagging using genome-scale intron-targeting sgRNA libraries that, in combination with computer vision, enables the systematic detection of protein localization changes.
https://t.co/D97S3JrTth

[Ernst Schmid @ernstschmidd]

I’ll be presenting some of the work we’ve been doing in the Walter lab to leverage AlphaFold multimer interaction screens to better understand biological pathways. Excited to be part of a fantastic speaker lineup!

[Rapé Lab @RapeLab]

Woohoo! Really excited to present our discovery that stress response silencing is an active and regulated process that is tightly linked to neurodegenerative disease! @Nature @berkeleyMCB @UCBerkeley #MolecularTherapeutics

https://t.co/hNMgju8Wpp

[Kevin Dong @kevinduydong]

@RapeLab @Nature @berkeleyMCB @UCBerkeley Congrats! Such a cool story

[Kevin Dong @kevinduydong]

@tjflemin @theNCI @bloodgenes Congrats Travis, well deserved!

[Kevin Dong @kevinduydong]

@ernstschmidd is a programming wizard that cannot be stopped. Check out this amazing resource!

[Ernst Schmid @ernstschmidd]

We folded over 40,000 pairs of ~300 human #genomemaintenance proteins with #AlphaFold multimer. Check out all the structures and the analysis at https://t.co/n1Yy3hoFLl! #cshreplication

[Kevin Dong @kevinduydong]

I'm thrilled to be part of an incredible lineup and excited to share my work from the @GygiLab on covalent drug discovery for the UPS using multiplexed targeted proteomics!

[Mikołaj Słabicki @biomiko]

Check out our final program for TPD Hybrid Meeting, on September 14th, 12-7pm, The event features seminars, panels, flash talks, and networking opportunities.
https://t.co/h4et0Ym9bh

[Chris Nardone @ChrisNardone95]

Very happy to share my second paper from grad school out today @ScienceMagazine! Read about how midnolin catches nuclear proteins for ubiquitination-independent proteasomal degradation. Stay tuned for more exciting work to follow. https://t.co/dRA20AJaGe

[Ernst Schmid @ernstschmidd]

Excited to share that our paper on DONSON’s role in eukaryotic replication initiation is now out in Science! Congrats to the whole Walter lab team and our collaborators in the Jackson lab! https://t.co/cddWvUULSY

[thecodingbiologist @codingbiologist]

Wishing you could easily edit your #AlphaFold PAE plots to make publication quality figures? Try out my latest tool, a PAE viewer that allows you to easily upload, edit, and export high quality plots. https://t.co/UTpyZSLPAt.

[Nucleate @NucleateHQ]

@NucleateHQ is pleased to invite the greater life science community to the Genesis 2022 Final Pitch Showcase on June 3rd at 3PM ET.

Genesis is Nucleate's free and open venture creation program.

Please RSVP for this in-person event by May 31st https://t.co/JtKCt7MSVk

[Anthony Rullo: chemically modulating proximity @LabRullo]

Building on pioneering work by @CarolynBertozzi @ChemicalBiology @DASpiegel256 @SchreiberStuart we report a covalent immune proximity induction strategy using electrophilic peptides !
https://t.co/xPQQEDNsQx

[College of Chemistry @UCB_Chemistry]

Exciting new research from the labs of @AlannaSchepartz and @TaatjesL defines new way to inhibit the most commonly mutated gene underlying human tumor growth.
https://t.co/Ibr8BxBU6S

[Dan Nomura @DanNomura]

The emerging role of mass spectrometry-based proteomics in drug discovery | Nature Reviews Drug Discovery https://t.co/9jaw7sE96C

[Kevin Dong @kevinduydong]

@MertensLab Huge congrats Jerome!

[Kevin Dong @kevinduydong]

@qinggaochem Hi Qing! Consider looking at the Gygi Lab. I am a bit biased, but am having a good time. Feel free to message me if you want to chat about careers. I too was very confused during my senior year and even during my gap years. I am a little less confused now so happy to chat