Len Boyette

proud @okta/@ycombinator alum + 500 bots in a trench coat

[Len Boyette @kevlened]

@DozaTacoza @paulg Capitalism is natural selection usefully applied to humanity. One simple rule removes bias about who should win. Let competition decide.

[Len Boyette @kevlened]

@DozaTacoza @paulg Meritocracy is the only thing that exists in nature. Natural selection is literally the process of the best being rewarded.

[Len Boyette @kevlened]

@mhp_guy Staying is an act of service

[Len Boyette @kevlened]

Allegations of slop are less interesting than slop

[Len Boyette @kevlened]

@RodDMartin Seems unlikely that lifespan, childbearing windows, childbearing methods, and immigration are all mostly unchanged for the next 75 years

[Zane Koch @zanehkoch]

ok actually insane paper published yesterday

a research group in Korea built a gene switch you can control wirelessly using electromagnetic fields

they exposed mice to 60 hz EMF (same frequency as your wall outlet) using a pair of large coils that generate a uniform magnetic field around the animal, for cyclic 3-day on / 4-day off pulses

they showed this could:
- activate OSK to do epigenetic reprogramming in progeroid and aged mice, extending lifespan and reversing aging markers across multiple tissues
- conditionally switch on mutant amyloid genes only in aged mouse brains, letting them separate aging effects from amyloid effects to study AD biology in a way previous models couldn't

no drugs, no impacts, just a magnetic field from outside the body

[Len Boyette @kevlened]

I've had 3 close calls while crossing SF intersections in 3 days. With better tracking of minor driving offenses, self-driving would be even more obvious.

[Len Boyette @kevlened]

@thdxr @beginbot

[Len Boyette @kevlened]

Still, the media firehose is unsatisfying. I want the serenity of feeling informed like my father had after reading the paper for 20 minutes each morning.

[Len Boyette @kevlened]

To form a balanced view, I consume media from increasingly polarized perspectives on any given topic.

[Len Boyette @kevlened]

A bright side of consuming strongly opposing views is it contains a lot of information "surprise" to update priors.

[Len Boyette @kevlened]

@jarredsumner @izs What if the colon was doubled to minimize the breakage?

"a::win32"
"b:c::win32"

[Len Boyette @kevlened]

@jasonlk importantly, also said:

"I have noticed investor updates with metrics don’t predict success, but investor updates without metrics that tell a really fancy story, but don’t have metrics, are actually quite predictive of failure. Those companies always fail."

[Len Boyette @kevlened]

@jasonlk "And no investor updates are fine. There’s a bunch of successful companies that just never … We never sent investor updates. I’m sorry for all the investors, but we’re bad communicators."

- John Collison with Des Traynor on Cheeky Pint

https://t.co/RMUgQ5RtHy

[Len Boyette @kevlened]

@ergrilmuit @davidasinclair @grok it may be an extrapolation from this May 2025 study: https://t.co/OVKB25jbK8

"cancer patients with high muscle strength or [cardiorespiratory fitness] levels ... had a significant reduction in risk of all-cause mortality by 31-46%"

[The Figen @TheFigen_]

They are ants solving a geometric problem and it is great in color.

[Len Boyette @kevlened]

@cardon_brian From the SSA: https://t.co/UPVqkdeIin

[caesararum, BS, DOGS @caesararum]

startup founders be all like

[Len Boyette @kevlened]

@madarco @jarredsumner his first screenshot compares the nodejs AWS sdk (in node and bun) and Bun.S3 in performance

his second screenshot compares the nodejs AWS sdk and Bun.S3 in developer experience

what would you like to compare?

[Len Boyette @kevlened]

@andrecasaldev @mattpocockuk CSP won’t help here. It only works on the client, which shouldn’t have access to secrets