Keyong

PhD Candidate in Department of Clinical Epidemiology, Leiden University Medical Center

[Eric Topol @EricTopol]

This is a big bust, folks
The first large scale (N>8000 participants) for lowering Lp(a) did not meet its primary endpoint for reducing adverse cardiovascular outcomes (vs placebo) https://t.co/dNV6RHXtJb

[JACC Journals @JACCJournals]

🚨 Risk prediction in primary prevention

In 79,497 Chinese adults w/o #ASCVD, PCE & China-PAR overestimated 10-yr risk, while PREVENT underestimated it

🔧 Recalibration to local data improved calibration & risk stratification https://t.co/3aKcGvZrVt #JACCAsia #ACCIntl

[JAMA @JAMA_current]

Among adults with high-risk #diabetes and elevated LDL cholesterol, evolocumab combined with statins reduced rates of major cardiovascular events compared to statin alone.

https://t.co/flA0oAua4C

[The Lancet Diabetes & Endocrinology @TheLancetEndo]

New—Multi-ancestry polygenic risk scores for the prediction of type 2 #diabetes and complications in diverse ancestries https://t.co/wdl8zlWNiD
#T2D #genetics
#OpenAccess

[Nutrition Science @NutrioSci]

Top 3 dietary risks behind 5.9 million heart deaths globally. #Nutrition #dietary

High sodium, low fruit, and low whole grain intake are the primary drivers

Paper
https://t.co/CGo0kp2XQJ

EurekAlert! News
https://t.co/LPKrWrt6Nm

[NEJM @NEJM]

Combined oral contraceptives and hormone-replacement therapy increase the risk of venous thromboembolism, although the absolute risk is low. Transdermal estradiol and micronized progesterone carry lower risk.

Learn more in the Review Article “Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk” by Leslie Skeith, MD, MHPE, and Shannon M. Bates, MDCM, from @ucalgary and @mcmasteru: https://t.co/aJBy0Qga6d

[Ｊｕｎ Ｙａｓｕｄａ @jyasuda1]

47万人のUKバイオバンクのゲノム中のコピー数多型と各種形質との関連解析の結果がNatureに出ている。質量分析計できちんと裏を取り、pQTLを検出しているようだ。痛風などとの新規の関連も見出している。
https://t.co/dkKLxpOfS5

[Epidemiology Job Openings (EpiJobs) @Epijobs]

Post Doctoral Fellow
Atlanta, GA United States #Epijobs
https://t.co/UOUh7C7p9p

[Science Magazine @ScienceMagazine]

GDF15, which is thought to contribute to nausea during pregnancy, may keep our drinking in check, researchers propose.

Learn more: https://t.co/3RkplsD2P6 @NewsfromScience

[Epidemiology Job Openings (EpiJobs) @Epijobs]

IQVIA is hiring a Home-Based Senior Epidemiologist. Must have a doctorate degree in Public Health, Health Sciences, Epidemiology or related field, plus proficiency using real-world data (RWD).
Boston, MA United States #Epijobs
https://t.co/wAwQI3w8dD

[Epidemiology Job Openings (EpiJobs) @Epijobs]

IQVIA is hiring a Home-Based Principal Epidemiologist in Vaccines. Must have a PhD in Epidemiology or related field, plus experience designing and/or leading RWE/Epidemiology studies.
Durham, NC United States #Epijobs
https://t.co/S0HE8khBoO

[Epidemiology Job Openings (EpiJobs) @Epijobs]

Epidemiologist/Data Scientist
Edinburgh, United Kingdom #Epijobs
https://t.co/jPkLNr3GCD

[Epidemiology Job Openings (EpiJobs) @Epijobs]

RWE Epidemiologist
London, United Kingdom #Epijobs
https://t.co/cHnJBeW1WK

[Epidemiology Job Openings (EpiJobs) @Epijobs]

Post Doctoral Medical Fellow - Applied Biostatistics, Clinical Trial Simulation, Remote
Ridgefield, CT United States #Epijobs
https://t.co/RhmypHZXiz

[Diabetes Care, an ADA research journal 🌟 @DiabetesCareADA]

In a large, pooled sample of US pregnant women from the NIH ECHO Cohort Consortium, greater concentrations of PFAS were not associated with higher prevalence of GDM. #DCare #Article

Read here ➡️ https://t.co/2fx6uo9qac

@AmDiabetesAssn @ADA_DiabetesPro @ADA_Pubs

[NEJM @NEJM]

Presented at #ACC26:

Among patients with a preserved ejection fraction at least 1 year after myocardial infarction, stopping beta-blockers was noninferior to continuing therapy with respect to major clinical outcomes. Full SMART-DECISION trial results: https://t.co/dZS03RaTcA

@ACCinTouch

[NEJM @NEJM]

Presented at #ACC26:

Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter. Full Ez-PAVE trial results: https://t.co/q0vNdAoJJL

Editorial: Paving the Road toward Targeted Lipid Lowering https://t.co/zUwmo0r0n4

@ACCinTouch

[Ethan J. Weiss @ethanjweiss]

Another win for the lower is better crowd…

Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease | New England Journal of Medicine https://t.co/z8WqTaeLSJ

[Jay Bradner, M.D. @jaybradner]

Telomeres are longer on the West Coast. Been in SoCal for only eight months and can already feel it. Nice GWAS on leukocyte telomere length and genetic associations in @NatureGenet by @pnatarajanmd and colleagues. https://t.co/Rm0uadOjWh

[Eran Segal @segal_eran]

Our new study @NatureMedicine from the Human Phenotype Project: Analyzing diet and microbiome data from 10,000+ people, we found that what you eat is strongly linked to which microbes live in your gut, down to specific foods like coffee, yogurt, and milk driving distinct microbial signatures. We also simulate personalized dietary interventions with predicted microbiome shift effects that are associated with improvements in cardiometabolic health

Read here: https://t.co/JoIEoIqJ6O

HPP: https://t.co/sdxsQpoStl