Komor Lab

Lab of Dr. Alexis Komor at the University of California, San Diego | Precision Genome Editing + The Chemical Biology of DNA Damage and Repair

[Komor Lab @KomorLab]

In observance of of #ShutDownSTEM we have drafted a Statement of Support for the #BLM movement with a list of actions we will take to combat racism and enforce equity and diversity in our community #BlackLivesMatter #ShutDownAcademia @UCSDChemBiochem @AcademicChatter @UCSDPhySci

[Nature Biotechnology @NatureBiotech]

Precise, minimally evolved adenine base editors generated through mutation reversion analysis https://t.co/cWSs7Q8srF

[UC San Diego School of Physical Sciences @UCSDPhySci]

Congrats to @UCSDAstro's Dusan Keres and @KomorLab on making the 2025 list of #HighlyCitedResearchers for their contributes extending the frontiers of knowledge and to innovations that make the world healthier and more sustainable.” @UCSDChemBiochem

https://t.co/MsB0c8Iw3H

[Gene Yeo’s Lab at UC San Diego @yeo_lab]

Excited to share my talk hosted by UCTV "A Closer Look at…Genetic Medicine and Artificial Intelligence" discussing RNA, AI and genetic medicine. Together with @KomorLab https://t.co/T5q8Syf1nv via @YouTube

[Nicole M. Gaudelli @NicoleGaudelli]

.@SecKennedy - thank you so much for your broad support for gene editing and gene therapies as well as recognizing the importance of Baby KJ’s story and the potential that CRISPR base editing therapies hold for patients with severe genetic diseases. I’m thrilled you have publicly recognized the Herculean efforts that made KJs therapy possible, from the physicians @CHOP like @kiranmusunuru and Rebecca Ahrens-Nicklas to the technological innovation in @davidrliu and @BKleinstiver labs, and especially the coordination and cooperation of the regulators @US_FDA that made this possible.

The gene editing medicine KJ received, a CRISPR adenine base editor was invented and developed in @davidrliu lab @Harvard with government grants from the NIH. This life-saving medicine, and so many future technologies, could not and will not be possible without government grants such as the one that supported this work, but are now shut off by this administration.

So PLEASE ask this administration to stop attacking our academic institutions and restore government funding to @Harvard (where again, KJ’s medicine was created!!) We cannot have stories like KJ’s without full and unwavering support from the US government.

Please help, please.

[STAT @statnews]

Ten scientists are leading a new generation of gene editors developing CRISPR medicines. Names include @KomorLab, @jgooten, @omarabudayyeh, @pdhsu, and @bsadamson.

See the full list here: https://t.co/Tcz196rGBu

[Komor Lab @KomorLab]

Thank you @MeganMolteni for including me in this amazing lineup of scientists!

[Fyodor Urnov @UrnovFyodor]

.@MeganMolteni's pitch-perfect lineup of the best talent in clinic-enabling gene editing - study their papers as a masterclass and rejoice. @KomorLab @MarsonLab @pdhsu @bsadamson @BKleinstiver @kiranmusunuru @cgersbach @sahakris
https://t.co/qisbkvBpdd

[Eric Topol @EricTopol]

The impact of CRISPR genome editing transcends potential cures. It's changing our understanding of what drives cancer and new ways to intervene
@ScienceMagazine by @KomorLab and colleagues
https://t.co/U0q0FrVy3v

[Nicole M. Gaudelli @NicoleGaudelli]

Congratulations to @davidrliu for being awarded the 2024 A.I. Scott medal in Chemistry. It was also the first time all four of us presented at the same event! @KomorLab

[Nature Methods @naturemethods]

Research Highlight by @madhuramukho: Multiplexed Orthogonal Base Editor (MOBE) systems developed by @komorlab, @quinn_cowan_sci & colleagues is a suite of tools that use RNA aptamer systems to enable simultaneous distinct point mutations at different loci.
https://t.co/d5pswLEUfK

[Quinn Cowan, PhD @Quinn_Cowan_sci]

Thank you @naturemethods @madhuramukho for highlighting our research: Development of Multiplexed Orthogonal Base Editor (MOBE) systems! 🧬@KomorLab @UCSDChemBiochem @UCSDPhySci https://t.co/DACPhJybGn

[The Scientist @TheScientistLLC]

Base editing can introduce a precise mutation into the genome. But what if one wants to make multiple different types of base edits at the same time?

That’s why @KomorLab from @UCSDPhySci created MOBE, a multiplexed base editing toolkit.
https://t.co/xkSSshIYeb

[Nature Biotechnology @NatureBiotech]

Development of multiplexed orthogonal base editor (MOBE) systems https://t.co/SAGoFkAPbV

[Quinn Cowan, PhD @Quinn_Cowan_sci]

Excited my PhD work is out now @NatureBiotech!

We report Multiplexed Orthogonal Base Editor (MOBE) systems: tools to simultaneously install distinct point mutations. MOBEs introduce co-occurring genetic variants (polygenic disease, haplotypes)��

🧵⬇️ 1/ https://t.co/6flqNaZdLW

[Komor Lab @KomorLab]

@Quinn_Cowan_sci’s paper is out today!

[Nature Biotechnology @NatureBiotech]

Development of multiplexed orthogonal base editor (MOBE) systems https://t.co/SAGoFkAPbV

[Komor Lab @KomorLab]

Congrats to Dr. Cowan @Quinn_Cowan_sci who just defended his thesis! He aptly celebrated the occasion with a lei made of the flow cells from his HTS runs. Be on the lookout for his paper, which is coming out soon! 👀🎉

[Gene Yeo’s Lab at UC San Diego @yeo_lab]

@HugoMedinaMunoz @EricKofman Huge thanks to our collaborators @KomorLab and Rahul Kohli, who were instrumental in this work. We also thank @NatureComms for the opportunity to publish our work!

[Komor Lab @KomorLab]

Congrats to Dr. Ranzau @brodieranzau who defended his thesis yesterday! If you haven’t yet checked out his awesome work detecting DNA editing activity by wtTAdA, give it a read here: https://t.co/838KenHq9V

[Komor Lab @KomorLab]

Congrats to Dr. Porto @ElizabethMPorto who defended her thesis today! Next up she is heading to Boston to start a job as a life sciences consultant at Clarion!!

[Research Corporation for Science Advancement @RCSA1]

So delighted to welcome our 1st Holland Award recipients to the #CottrellScholar community! Luis Colón @LuisColonLab, Raychelle Burks @DrRubidium, Jane Liu @pomonacollege, Malika Jeffries-El @Chem_Diva, Ted Goodson @MichiganChem & Robert Gilliard @rjgilliard.

[Komor Lab @KomorLab]

It’s always a fun, insightful, and thought-provoking time when @RCSA1 holds a conference. Got some really great ideas for promoting cultural change, thanks so much to @jenheemstra @TehshikYoon and our fearless leader @ronco_sronco for leading/organizing!

[Javier M. Duarte @jmgduarte]

Had some great discussions at my first @RCSA1 #CottrellScholar Conference! Got to catch up with @UCSDPhySci @UCSDPhysics @UCSDChemBiochem colleagues @markherzik @KomorLab Alex Fraño and Lena Koslover and meet a lot of new people