Kat Mueller, PhD

Postdoc @EvanWeberPhD @ChildrensPhila | Fellow @CancerResearch | Fellow @IDEAL_Research | #CART | #SingleCell |#InclusiveTeaching | She/Her 🏳️‍🌈

[Kat Mueller, PhD @kpmueller1]

I'm wildly proud to share our FIRST Weber Lab paper, out today in @Nature! I want to share a story about how this whirlwind of a project came together. A 🧵 on teamwork, open science, and how far we can go when we intentionally build a culture of trust in research. 1/

[Evan Weber @EvanWeberPhD]

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?

We answer this in our lab’s first paper in @Nature led by @alexdoan96 @kpmueller1 @andy_yhchen. 1/

https://t.co/qvTdqoeduz

[Evan Weber @EvanWeberPhD]

Our new, comprehensive review on CAR T cell persistence is officially published in @CellCellPress @trendscancer. Fantastic work from lead authors @kpmueller1 @JGrenierMDPhD.

Link to the full article:

https://t.co/4a0lsoqHtm

[E. John Wherry @EJohnWherry]

Congratulations! So well deserved!!

[Kat Mueller, PhD @kpmueller1]

@HindRafei @EvanWeberPhD @trendscancer @JGrenierMDPhD Thank you so much, Hind! We would love to hear what you think!

[Kat Mueller, PhD @kpmueller1]

Our field has come a long way since the first CAR T success stories; still, reliable CAR T persistence remains elusive. Our goal is to highlight both lessons learned and open questions, which we hope will one day lead to consistently durable cures. Thanks for reading! /🧵

[Kat Mueller, PhD @kpmueller1]

Durable CAR T persistence is among the great unsolved challenges within our field. But what do we actually mean when we say a CAR T cell is "persistent"? @JGrenierMDPhD, @EvanWeberPhD and I attempt to answer this question in our new review @trendscancer. 1/

[Kat Mueller, PhD @kpmueller1]

Finally, we propose a unifying framework to define the concept of CAR T "persistence". We argue that the underlying mechanisms likely differ between active tumor killing vs. long-term immunosurveillance; we refer to this as "type I" and "type II" persistence, respectively. 5/

[Kat Mueller, PhD @kpmueller1]

Thrilled to see this work out - congratulations to Dan Pham on a beautiful paper!

[Melissa Skala @melissa_skala]

Congratulations to Dan Pham for her paper published today! Dan showed that autofluorescence lifetime imaging can monitor single cell metabolism to improve CAR T cell metabolic fitness. @sahakris @UWCarbone @Morgridge_Inst @UWMadEngr
https://t.co/TnioBdYTy5
https://t.co/EEvzZrkGA0

[Kat Mueller, PhD @kpmueller1]

This is terrifying, heartbreaking, infuriating.

[Kelton Minor @keltonminor]

There are days in life that shake you.

I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at @Columbia & academic career... 1/🧵

[Kat Mueller, PhD @kpmueller1]

Thanks for the shout out, Evan! I'm so honored to work with @CancerResearch, and psyched to get started on these experiments!

[Evan Weber @EvanWeberPhD]

Congrats to our talented postdoc @kpmueller1 on receiving this prestigious and competitive @CancerResearch award! Big things to come!

[DrORourke @DrORourke2]

Patient-derived glioblastoma organoids as real-time avatars for assess... https://t.co/MGZYFFoT0V
Happy to report our work using #GBM organoids to predict #CART response in #glioblastoma @PennCancer

[Kai Tan Lab @KaiTanLab1]

Excited to share our latest work in @NatureCancer to get a better understanding why relapsed T-ALL is so deadly and potential target strategies, led by Jason Xu and @changya1 with members of David Teachey, @junjyang, @CMullighan and many great colleagues. https://t.co/SaG7Q74FMS.

[Neil Stone @DrNeilStone]

If only we had data on vaccine efficacy

IF ONLY WE HAD THE DATA

#vaccineswork

[NatureRevClinOncol @NatRevClinOncol]

In this new Review, Caroline Diorio, David Teachey & Stephan Grupp discuss the progress made and remaining roadblocks with allogeneic CAR cell therapies for cancer: https://t.co/9CXeGnKa10

[Kat Mueller, PhD @kpmueller1]

@WeitzmanLab @CancerResearch @EvanWeberPhD @ChildrensPhila Thank you Matt! Couldn't have done it without everything I learned in GPS!

[Kat Mueller, PhD @kpmueller1]

I'm honored to share that I have been awarded an Irvington Postdoctoral Fellowship from @CancerResearch! This funding will support my ongoing CAR T cell therapy research with @EvanWeberPhD at @ChildrensPhila. 1/

[Kat Mueller, PhD @kpmueller1]

@CancerResearch @EvanWeberPhD @ChildrensPhila @CarolineDiorio @GruppSteve @KaiTanLab1 And of course, I am beyond thankful for my friends in the Weber Lab, and for our fearless leader @EvanWeberPhD. I am the luckiest postdoc in the world to work with such brilliant, generous and kind scientists. You inspire me every day! 3/3

[Kat Mueller, PhD @kpmueller1]

@CancerResearch @EvanWeberPhD @ChildrensPhila I am deeply grateful for my colleagues and mentors who supported me through many iterations of this proposal. Huge thanks in particular to Suzi McClory, Alice Wang, @CarolineDiorio, @GruppSteve, and @KaiTanLab1, all incredible collaborators who have taught me so much. 2/