Hofmann_Lab

Research group at the University of Cologne

[Hofmann_Lab @LabHofmann]

Our paper on bacterial clippases is now out in @MolecularCell. These really interesting enzymes can make deconjugation of #ubiquitin irreversible. Thanks to @UniCologne and @C2fBiochemistry for support.
https://t.co/78lxodHhQa

[Hofmann_Lab @LabHofmann]

@Rashmi_Agrata Looks like a great opportunity! I would join if I could. 😉

[Hofmann_Lab @LabHofmann]

@FelthamLab @WEHI_research Great Job, Jake et al!

[Feltham Lab @FelthamLab]

Proud to share The E3-ome

A true collaborative effort to unify the human E3 ligase landscape, and create a shared foundation for the field

#Ubiquitin #E3Ligases @WEHI_research

https://t.co/yK0jtcCp7P

[Hofmann_Lab @LabHofmann]

I am deeply saddened learning that my scientific hero Amos Bairoch has recently passed away. He will be remembered as the mastermind behind the SwissProt and many other endeavours in protein bioinformatics. There is a tribute web page at https://t.co/ku46u3iQVG

[Hofmann_Lab @LabHofmann]

@TrujilloLab ... and the Isono Lab (Konstanz)

[Hofmann_Lab @LabHofmann]

@DrRanabirDasLab @RanabirNMR Congratulations!

[Hofmann_Lab @LabHofmann]

For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. https://t.co/274nqCYDeO

[Hofmann_Lab @LabHofmann]

Very interesting finding from the Escobar group next door, with some minor contributions from us.

[Molecular Cell @MolecularCell]

Online Now: Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity https://t.co/GkHutY4Qaa

[Ranabir Das @RanabirNMR]

Measure protein deamidation by bacterial secreted proteins? Check out the recent NMR paper. Congratulations to @Rashmi_Agrata
https://t.co/WGGjeSeWPS

[MPI Dortmund @mpimoph]

New Parkinson’s disease paper:
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by @MalteGersch group @maxplanckpress in @Nature Struct. & Mol. Biol.
https://t.co/VoRJybRUUI

[Niko Klink @NikolasKlink]

Excited to share that our work on Parkinson's target USP30 has been published in Nature Structural & Molecular Biology! By combining DUB-domains onto USP30, we for the first time achieved crystallization with a small molecule (NK036) without Nanobodies! https://t.co/Pt2hy4WbqT

[Hofmann_Lab @LabHofmann]

@winklhofer_lab @oleschmoeker @MolecularCell @UniCologne @C2fBiochemistry Thank you, Konstanze !

[Hofmann_Lab @LabHofmann]

Our paper on bacterial clippases is now out in @MolecularCell. These really interesting enzymes can make deconjugation of #ubiquitin irreversible. Thanks to @UniCologne and @C2fBiochemistry for support.
https://t.co/78lxodHhQa

[Hofmann_Lab @LabHofmann]

Congratulations, great paper! But what makes you think that this is a CARD and not just any death-fold domain? pyrin and DEDs can also activate caspases and invertebrates use all kinds of death-fold domains for that purpose! I don't think this one really should be called CARD.

[Tanita Wein @TanaWein]

We previously showed that bacteria encode the pore-forming protein gasdermin and that it defends against phage infection
https://t.co/bnIAyYlqQK
BUT the mechanism by which the gasdermin system defends bacteria against phage remained unknown.

[Hofmann_Lab @LabHofmann]

Great paper, but sorry, this is *not* a CARD domain! It is a 6-helix death fold domain for sure, but there in no evidence provided that it belongs to the CARD subfamily. It might have (convergently?) acquired a similar function as mammalian caspase-associated CARDs. Just saying.

[Sorek Lab @SorekLab]

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems

CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems

Congrats @TanaWein! Thanks Kranzusch lab!
https://t.co/yWUj5ZMjjO

[Malte Gersch @MalteGersch]

Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! https://t.co/YTV5td5koG

[Ole Schmöker @oleschmoeker]

New Lammers Lab paper out now in @NatureComms!🥳
We reveal high functional diversity within bacterial deac(et)ylases by systematic functional/structural characterization.
This is Leonies PhD project and I’m grateful to have contributed to this great work.

https://t.co/UbAY45Hl5H

[Jane Dudley @Jane_Dudley_Lab]

Endlessly fascinating and exciting conference with great discussions #EMBOubiquitin24 ! Can’t wait to get back to the lab with some new ideas…

[Hofmann_Lab @LabHofmann]

@jnpruneda @PrunedaLab @camgroberts Fascinating