Anthony Rullo: chemically modulating proximity

Covalent and multivalent - proximity inducing strategies for basic and translational chemical biology

[J. Am. Chem. Soc. @J_A_C_S]

Triazenyl Furans as Diels–Alder Dienes | Journal of the American Chemical Society https://t.co/5taiuQvoZs

[Guillaume Laconde @Glaconde34]

Linker-Driven Sampling of PROTAC-Induced Ternary Complexes | Journal of Medicinal Chemistry https://t.co/XcOWJJxDWJ

[Nature Chemical Biology @nchembio]

A new series of covalent, monovalent glue degraders can co-opt two E3 ligases, DCAF16 and FBBXO22, in a parallel fashion to degrade SMARCA2/4 with chemically and genetically tunable ligase preference

https://t.co/azG0RCPFTt

[Ingo Hartung @HartungIngo]

It‘s time to remove the question mark!

A huge congrats to @CraigMCrews, Ray Deshaies and the scientists @ArvinasInc.

1st FDA approval for a #PROTAC on May 1st 2026. A day to remember. Extra drinks at the Proxidrugs GRC in a few weeks!

[J. Am. Chem. Soc. @J_A_C_S]

Fast and Selective Labeling of Serine and Threonine in HFIP for Facile Editing of Peptide Alcohol Side Chains | Journal of the American Chemical Society https://t.co/uZHLp9LsAt

[AK List @ListLaboratory]

Just out @J_A_C_S Confined Acids Catalyze a Broadly Applicable β-Selective O-Glycosylation

https://t.co/NDvgGPtSUN

[Guillaume Laconde @Glaconde34]

Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation | ACS Chemical Biology https://t.co/td5YeJwrAS

[Guillaume Laconde @Glaconde34]

Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation | Bioconjugate Chemistry https://t.co/DoUXr645uT

[J. Am. Chem. Soc. @J_A_C_S]

Discovery of Covalent Ligands with AlphaFold3 | Journal of the American Chemical Society https://t.co/TYukOecxP6

[J. Am. Chem. Soc. @J_A_C_S]

Confinement Catalysis Enables Macrocyclization at Up to 0.6 M: Selective Formation of Mono- and Dimeric Glycosidic Macrocycles | Journal of the American Chemical Society https://t.co/xg8c7FaOv9

[MedChem & ONCo& @MedChem314]

Beyond traditional strain-promoted azide–alkyne cycloadditions by achieving orthogonality and rapid kinetics with fluoroalkyl azides
Nature Communications 2026
https://t.co/0VJixoPRF4

[J. Am. Chem. Soc. @J_A_C_S]

Discovery of Ultrapotent Heterodimeric Peptide Ligands Using Library-vs-Library RaPID Selections | Journal of the American Chemical Society https://t.co/0lBx7nMOln

[Guillaume Laconde @Glaconde34]

AI‐Based Prediction of PROTAC‐ and Molecular Glue‐Mediated Ternary Complexes: A Comparative Evaluation of AlphaFold 3 and Boltz‐2 - Riepenhausen - 2026 - Archiv der Pharmazie - Wiley Online Library https://t.co/R0AxBC23rn

[Nature Biotechnology @NatureBiotech]

A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors https://t.co/Yxr8BnPwwJ

[Anthony Rullo: chemically modulating proximity @LabRullo]

@vishal_iiserb @Novartis proximity effects ? ;)

[Anthony Rullo: chemically modulating proximity @LabRullo]

@SebVidalChem @dr_kuato

[Anthony Rullo: chemically modulating proximity @LabRullo]

@SebVidalChem @dr_kuato Canada isn't having a terribly easy time either....journal depending .....

[Fajie Chen @Fajie13]

Nature holds the keys to PPIs—why don't we use them? Some thoughts on stabilizing hotspots without sequence changes, using the emerging non-symmetric stapling. This could unlock the therapeutic potential of native peptides. Now out as @ChemRxiv preprint. https://t.co/XBaWxktLGI

[Anthony Rullo: chemically modulating proximity @LabRullo]

Farewell to a giant in chemical immunology and induced proximity

[Gaurav Chopra @chopralab]

Today I lost a dear friend, mentor, and colleague. Dr. Philip Low was a brilliant scientist whose discoveries transformed human health. I’m deeply saddened by Phil’s passing and grateful for his friendship and mentorship. His legacy will endure. https://t.co/UngCZcPntO

[Anthony Rullo: chemically modulating proximity @LabRullo]

@chopralab I'm so sorry to hear this. His contributions to synthetic immunology were an inspiration