Lori L Wallrath

U of Iowa BMB Professor with a passion for modeling rare human diseases in Drosophila, #musculardystrophy #lamins #retinitispigmentosa #RNAsplicing #chromatin

[Muscle Cell News @musclecellnews]

🔬 This study identifies FGF12 as a critical regulator of aberrant mechanosignaling in aortic smooth muscle cells and a key contributor to thoracic aortic aneurysm formation in Marfan syndrome.

🔗 https://t.co/ixmCmGwFmP

[Cell Press @CellPressNews]

Vascularized hiPSC-derived 3D cardiac microtissue on chip
https://t.co/4HlHfEdqCd
Article highlight from @stemcellreports (@ISSCR)
@LUMC_Leiden

[Muscle Cell News @musclecellnews]

This study delineated the state-of-the-art of muscle models by performing a large-scale analysis of transcriptome datasets, covering over 400 samples across 39 studies, including bulk and single-cell RNA sequencing of 2D and 3D models.

@stemcellreports | https://t.co/64sb6SD9K8

[Nature Plants @NaturePlants]

New OA Article: "RNA m6A regulates the transcription and heterochromatin state of retrotransposons in Arabidopsis" https://t.co/EFpeqif6Qa

m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...

[Hutch Basic Sciences @HutchBasicSci]

Congratulations to Dr. Steve Henikoff on receiving the 55th Rosenstiel Award for his research on genome organization and gene expression! The award is given for recent discoveries of particular originality and importance to basic medical research.
https://t.co/NKWpbT4UR7

[FlyBase @FlyBaseDotOrg]

The FlyBase situation has made the national news https://t.co/BbWAKJZNPC

[Matthew S. Alexander @Matt_Muscle_Guy]

New #SciTransMed paper: ADAMTS-5 inhibition reduces muscle inflammation and fibrosis and improves function in mouse models of Duchenne muscular dystrophy. https://t.co/rvzirI4aqL

[Andrew Belmont @belmont_andrew]

Happy to share our recent work showing bulk transport of speckle material between nuclear speckles within dynamic, multi-phase, linear connections.

Nonrandom interchromatin trafficking through dynamic multiphase speckle connections https://t.co/EfukGLSso2

[Eric Topol @EricTopol]

This week's genome editing triumph is a big deal.
Here's why
https://t.co/1ajD3p3ksi

[Lori L Wallrath @Labtacular]

Our recent studies on genetic modifiers of LMNA-associated muscular dystrophy identify components of SMAD signaling as potential therapeutic targets. https://t.co/HrM0lJ8wKQ

[Lori L Wallrath @Labtacular]

@LiMgrl_Uiowa Congratulations!! Well deserved!

[Gonzalo’s Lab @gonzalo_lab]

Excited to share our pre-print about a non-canonical cGAS-STING pathway in aging.

https://t.co/6pRIUwefCe

[Science Magazine @ScienceMagazine]

For the first time, researchers have used the #CRISPR gene editor to repair a flawed gene in the human body. https://t.co/ouaLHlg7fv @NewsfromScience

[Lori L Wallrath @Labtacular]

Blown away by the incredible research on muscle disease pathology and treatments at the Muscular Dystrophy Association’s 75th Anniversary Clinical and Scientific Conference! @MDAorg

[Lammerding Lab @LammerdingLab]

Interested in nuclear #mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @J_Cell_Sci:
https://t.co/vEwsJ8PMuy

[Muscle Cell News @musclecellnews]

💪 To find factors associated with muscle integrity, researchers at @Inserm perform an siRNA screen and identify SH3KBP1 as a new factor controlling #myoblast fusion, myonuclear positioning, and myotube elongation.

@emboreports | https://t.co/G61eXE7hTW

[LGMD Awareness Foundation, Inc @LgmdAwareness]

SAVE THE DATE!!
The Dystroglycanopathy Patient & Family Conference will be held June 20th & 21st at the Graduate Hotel in Downtown Iowa City!

[Genetics Society of America @GeneticsGSA]

We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research.

R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics.

Read an In Memoriam published in Genes to Genomes: https://t.co/Nabrvgthv7

[Lori L Wallrath @Labtacular]

Proud of Nathan Mohar, a graduate student in my lab, who was selected for the U of Iowa “Dare to Discover” campaign. Nathan is linking DNA sequence variation to phenotypic characteristics of LMNA-muscular dystrophy.

[UI Stead Family Department of Pediatrics @UIowaPeds]

Congratulations to our own Dr. Mathews on the MDA Legacy Award for Achievement in Clinical Research!