🔬 This study identifies FGF12 as a critical regulator of aberrant mechanosignaling in aortic smooth muscle cells and a key contributor to thoracic aortic aneurysm formation in Marfan syndrome.
🔗 https://t.co/ixmCmGwFmP
This study delineated the state-of-the-art of muscle models by performing a large-scale analysis of transcriptome datasets, covering over 400 samples across 39 studies, including bulk and single-cell RNA sequencing of 2D and 3D models.
@stemcellreports | https://t.co/64sb6SD9K8
New OA Article: "RNA m6A regulates the transcription and heterochromatin state of retrotransposons in Arabidopsis" https://t.co/EFpeqif6Qa
m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...
Congratulations to Dr. Steve Henikoff on receiving the 55th Rosenstiel Award for his research on genome organization and gene expression! The award is given for recent discoveries of particular originality and importance to basic medical research.
https://t.co/NKWpbT4UR7
New #SciTransMed paper: ADAMTS-5 inhibition reduces muscle inflammation and fibrosis and improves function in mouse models of Duchenne muscular dystrophy. https://t.co/rvzirI4aqL
Happy to share our recent work showing bulk transport of speckle material between nuclear speckles within dynamic, multi-phase, linear connections.
Nonrandom interchromatin trafficking through dynamic multiphase speckle connections https://t.co/EfukGLSso2
Our recent studies on genetic modifiers of LMNA-associated muscular dystrophy identify components of SMAD signaling as potential therapeutic targets. https://t.co/HrM0lJ8wKQ
Blown away by the incredible research on muscle disease pathology and treatments at the Muscular Dystrophy Association’s 75th Anniversary Clinical and Scientific Conference! @MDAorg
Interested in nuclear #mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @J_Cell_Sci:
https://t.co/vEwsJ8PMuy
💪 To find factors associated with muscle integrity, researchers at @Inserm perform an siRNA screen and identify SH3KBP1 as a new factor controlling #myoblast fusion, myonuclear positioning, and myotube elongation.
@emboreports | https://t.co/G61eXE7hTW
We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research.
R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics.
Read an In Memoriam published in Genes to Genomes: https://t.co/Nabrvgthv7
Proud of Nathan Mohar, a graduate student in my lab, who was selected for the U of Iowa “Dare to Discover” campaign. Nathan is linking DNA sequence variation to phenotypic characteristics of LMNA-muscular dystrophy.