Waggoner Lab

Research lab of Dr. Stephen Waggoner. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
@labwaggoner.bsky.social

[Waggoner Lab @LabWaggoner]

Spatial confinement promotes germinal center diversity and tempers immunodominance @NatImmunol @hhmi_science @UCSF
https://t.co/j68ZDV93CQ

[Waggoner Lab @LabWaggoner]

A single-cell atlas of human neutrophils reveals neutrophil heterogeneity across health and disease @NatImmunol @purveshkhatri
https://t.co/0DXh5XqPZF

[Waggoner Lab @LabWaggoner]

Tfh are a source of IL-2 that supports Treg cells in gut-associated lymphoid tissue, thereby promoting intestinal immune homeostasis & tolerance @NatImmunol
https://t.co/e17fS2mlM9
https://t.co/9cVT1XBJzw

[sunil acharya @sunilacharya13]

Huge congratulations @lab_rezvani on this well deserved recognition of your outstanding scientific contributions, visionary leadership, and unwavering commitment to advancing medicine and improving patients’ lives. Proud to be part of your team. 🎉

[Leonardo_DeLorian™_Call me D @Gr8CanadianFree]

I'm dead !!!! 😂😂😂😂😂😂

[Katy Rezvani, M.D., Ph.D @lab_rezvani]

Honored to be elected to the @NAMedicine! Grateful to the many talented colleagues and team members I’ve had the privilege of working with over the years. Especially delighted to share this recognition with @ACKoongMDPhD

[Eric Brown @ericmichbrown]

Personal update: The Brown Lab is up and running at Virginia Commonwealth University where I've joined as a faculty member in the Microbiology and Immunology Department.

I will be launching a research program focused on understanding the molecular mechanisms that prevent chronic inflammation and promote its resolution. This will include work on sphingolipid-immune interactions, extracellular vesicle biology and HLA-associated mechanisms in diseases such as IBD and spondyloarthritis.

The Brown Lab will be recruiting talented scientists to fill multiple positions. Feel free to reach out directly if this research area interests you.

[Waggoner Lab @LabWaggoner]

SIV reservoir depletion and clearance from neonatal macaques following transient CCR5 depletion @NatureMicrobiol @UCDavisMed https://t.co/1OIq2zhLfh

[Waggoner Lab @LabWaggoner]

Combination therapy with broadly neutralizing antibodies, antiretroviral therapy and CCR5 blockade limits viral reservoir seeding in infant macaque model of HIV @NatureMicrobiol @NLoganH @OHSUNews
https://t.co/84mOWnc7b1

[Waggoner Lab @LabWaggoner]

Dimeric granzyme-A mediates the specific recognition and cleavage of full-length GSDMB @NatureComms
https://t.co/Jk3Yalc5e4

[Richard Hanania @RichardHanania]

This is so perfect. Honestly, I thought "Tommy" was a plant by the way he walked off at the end. Abdul El-Sayed just looks too good here.

But after looking it up, I learned he was a former Josh Hawley staffer.

This is the most inspiring performance by an American politician that I can remember seeing.

El-Sayed was faced with a bigoted question. He didn't hide from it or pander. He broke down why it was a bigoted question, and gave a stirring defense of American principles and the Constitution.

At the end, his interlocutor wouldn't condemn Christian Nationalism! El-Sayed has a perfect response to this, and "everybody clapped."

A lot of us have had this experience of arguing with right-wingers, questioning them, and then finding out that they have no principles, they're just bigots. A Hawley staffer will talk about the US Constitution and freedom of religion to attack a Muslim politician, and sing a completely different tune when it comes to Christian fundamentalists.

Again, the "everybody clapped" nature of this, followed by Tommy walking off in shame, made me think that he was a plant.

But no. This was a real-life rightoid, getting exposed as the hateful, hypocritical bigot that he is in front of the entire world.

Abdul El-Sayed's rise in American politics has made me a lot more optimistic about our future.

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Germinal centers can persist for up to one year with declining somatic hypermutation and ongoing plasma cell output
https://t.co/f5uwD25Unc @profshanecrotty

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Persistently activated virus-specific CD8 T cells indicate antigen-driven immune aberrations in long COVID
https://t.co/kQSnrvWzux @EJohnWherry @IGGPenn @markmpainter @MichaelPelusoMD
@PutrinoLab @VirusesImmunity @nualameyer

[Mark Painter @markmpainter]

Our study on virus-specific T cell activation in Long COVID (LC) is up on bioRxiv! We identify a subset of people with LC with persistently elevated activation of CD8 T cells targeting spike and/or EBV lytic antigens, consistent with viral persistence.

https://t.co/A7ZEOKmyBP

[Waggoner Lab @LabWaggoner]

@biorxivpreprint @ragoninstitute Self-reactive human CD8+ T cells restricted by HLA-E mediate immunoregulatory and antiviral functions
https://t.co/tkPRSkjSpd @brucedwalkermd

[Waggoner Lab @LabWaggoner]

@biorxivpreprint GM–CSF modulates conserved ILC–like transcriptional states and myeloid cell signaling during ulceration in Crohns disease
https://t.co/TiiMF5pWsk @Felix_Chuang240 @IcahnMountSinai

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Noncanonical CD11b on CD8+ T cells promotes cytotoxic effector function
https://t.co/sLuYPHaAqf @AntonanaAsier @Ikerbasque

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Myeloid IRF5 is required for TLR7-driven inflammatory hemophagocyte differentiation and Macrophage Activation Syndrome @NatalieThulin
https://t.co/hiXCxqLRue

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Selective granzyme B replenishment dominates the molecular switch for sustained cytotoxicity in effector CD8+ T lymphocytes
https://t.co/YlTH880sda @Inserm

[Waggoner Lab @LabWaggoner]

@biorxivpreprint A defined multi-kingdom microbial consortium naturalizes the immune system of laboratory mice
https://t.co/NrvonNReks @CadwellLab @IGGPenn

[Waggoner Lab @LabWaggoner]

Review @TrendsinPharma
Engineering monocytes and macrophages for therapeutic control
https://t.co/BCsrUwsqUw