Abhilash Padavannil

[UC Davis Physiology @ucd_physiology]

Big news! We’re thrilled to announce that #PMB member Dr. Aldrin Gomes has been named a Presidential Awardee for Excellence in Science, Mathematics, and Engineering Mentoring (PAESMEM). Congratulations to @gomes_lab on this much-deserved achievement!🌟🔬https://t.co/TmzsId0Dnh

[Membrane Protein PDB @MemProtPDB]

Formation of I2+III2 supercomplex rescues respiratory chain defects | Cell Metabolism

https://t.co/JaetISyjEN

[Abhilash Padavannil @lashbt]

@LettsScience @ucdavis @ucdavisbiology @CAMPOSUCDavis1 Congratulations James!!!

[James A. Letts @LettsScience]

Extremely honored and humbled to be awarded the Presidential Early Career Award for Scientists and Engineers (PECASE).
This is a testament to the work of the amazing people in my lab current and previous.
@ucdavis @ucdavisbiology @CAMPOSUCDavis1
https://t.co/V7cu80f95w

[Lena Ho @Holab_DukeNUS]

Ever wondered why we need respiratory supercomplexes?
New findings from our lab, in collaboration with @LettsScience, show how a specialized supercomplex - the SC-XL - can help mitochondria overcome some respiratory defects & provide cardioprotective benefits.
Studying #Microproteins (i.e. Brawnin) led to this amazing discovery, a testament to the power of small!
https://t.co/FVnqZYq2PV

[James A. Letts @LettsScience]

What are respiratory supercomplexes (SCs) doing?

Our collaboration with @Holab_DukeNUS shows that an extra large SC forms between complex I and complex III in a mouse model of complex III deficiency. SC-XL rescues the respiratory defect.

https://t.co/XvMRrDaBmx

[Yuh Min Chook @yuhminchook]

Shoutout to former/current @ChookLab members - Ertugrul Cansizoglu for starting the work and taming Msn5, Takuya Yosizawa for getting over the big barrier of phosphorylating Pho4, and the amazing Joyce Fung for putting it together and showing how it works!
https://t.co/w3hANQnaDA

[Nitzan Shabek @ShabekLab]

and thanks to ALL authors 🙏, especially @ShabekLab postdoc Malathy Palayam for her fantastic work on this project, and our collaborators in Dinesh-Kumar @ucdavisbiology @ucdavis and @BoyerFranoisDi1 labs.

[Abhilash Padavannil @lashbt]

@ATsabareesan @UTSWPostdocs @biophysics_utsw @utswpda Congratulations Sabareesh!!!!

[Michael Cianfrocco @mcianfro]

Such cool #cryoEM structures from @Jen_Cash_11 ! Jen started pulling on the thread of these structures while she was still @UMLifeSciences in the lab before starting her own group - careful 2D & 3D average inspection/selection + biochemistry = 🤩

[Maria Ayala @ayalahemaria]

I am deeply honored to be a part of the #GilliamFellows community. Thank you to all of my past and present mentors for all of your assistance and support. Special thanks to @LettsScience, @mm5200, @partchlab, @Elva_Diaz11, and @CruzOrengo.

[James A. Letts @LettsScience]

Absolutely thrilled that my fabulous @BMCDB student @ayalahemaria has been recognized as a #GilliamFellows, looking forward to continuing our scientific journey together! @HHMINEWS @ucdavis @CAMPOSUCDavis1

[Yuh Min Chook @yuhminchook]

Solution studies by @DArcy_Lab_UTD and @ChookLab explain the atypical RanGTP-Importin-9-H2A-H2B nuclear import complex in partner paper https://t.co/jwMCQA6VJN

[Abhilash Padavannil @lashbt]

The latest work from @LettsScience Letts lab reporting the structure of mitochondrial CI from Drosophila is now out.

https://t.co/8TMAp5v5Cm

[Hannah R Bridges @HannahRBridges1]

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides https://t.co/VDqiU5Bizj

I think you all deserve a new 🧵

[María Maldonado @mm5200]

Had a blast presenting our work at the @Boomerang meeting. Thank you so much for your support!

[Abhilash Padavannil @lashbt]

@mm5200 @boomerang Congratulations @mm5200 !!!

[María Maldonado @mm5200]

In both mung bean and Arabidopsis, the structures of SC I+III2 show the complete structure for complex I, including NDUA11 (B14.7) and a new plant-specific subunit NDUP9 at the SC interface.