Laura Santini

Science & Art lover,
PostDoc in @TommyVierbuchen lab at @MSKCancerCenter,
PhD in the @leeboratory at @viennabiocenter

[Thomas Vierbuchen @TommyVierbuchen]

Excited to share our latest manuscript, a collaboration with @JustinPerryPhD led by @WeillCornell neuroscience PhD student @AnnBaako. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.

https://t.co/gTD7V4mSoz

[Max Perutz Labs Vienna @MaxPerutzLabs]

🆕 publication! 🧬 How do enhancers, located far away in the genome, communicate with their target genes? In @MolecularCell, the lab of @chribue shows how different enhancers cooperate to drive gene expression using a novel synthetic platform ➡️ https://t.co/0Uz3XCNTei

[Laura Santini @laura__sa]

I'm honored to have received the VBC PhD Award for my Thesis!

[Max Perutz Labs Vienna @MaxPerutzLabs]

👏🎉 Congratulations to Perutz alumna Laura Santini on receiving the Vienna BioCenter PhD Award! Her outstanding thesis focuses on a crucial cell state transition during early embryonic development 🧫➡️ https://t.co/rxyH9tij2T

[Thomas Vierbuchen @TommyVierbuchen]

Excited to share the latest work from my lab and @em6wong led by @DanielMedinaC12 @tarek10281 @verpetrova.

We developed a new protocol to generate mouse cortical organoids from pluripotent stem cells.

@MSKCancerCenter @MSK_CSCB @MSKEducation

https://t.co/JSOnogfLuC

[Laura Santini @laura__sa]

Latest preprint from our lab is now online! Huge congratulations to all authors! Go check out the story led by amazing @DanielMedinaC12

[Daniel Medina Cano @DanielMedinaC12]

Beyond excited to share my main postdoctoral work. We developed a robust mouse cortical organoid system, which recapitulates in vivo tempos and cellular diversity, and applied it to identify gene expression changes across subspecies during development. https://t.co/XQLx6TF3T2

[ESC & iPSC News @ESC_iPSC_News]

🔬 Dr. Laura Santini (@laura__sa) and scientists at @univienna demonstrated that phosphorylated AKT acted as a 🚧 gatekeeper that prevented nuclear localization of FoxO transcription factors in naïve ESCs.

@NatureComms | https://t.co/vFzhIxq6L6

[The Leeboratory @leeboratory]

Great science by @laura__sa . Great and funny artwork by @LuisMiguel2890 . Great teamwork by the Leeboratory !

[Laura Santini @laura__sa]

In sum, in our work we uncovered a previously unappreciated role for FoxO TFs in instructing formative identity. If this thread hooked you up, go check the whole article for more details!

[Laura Santini @laura__sa]

I’m thrilled to finally see the main project of my PhD in the @leeboratory out in #NatComms. Congrats to all authors and collaborator @NRivron !
We identified FoxO transcription factors as crucial AKTors in the naïve to formative pluripotency transition.
https://t.co/dtkNOJhtgo

[Laura Santini @laura__sa]

Finally, we forced FoxO TF nuclear shuttling by treating naïve and formative cells with an Akt inhibitor and observed a specific upregulation of core formative pluripotency genes which are FoxO1 targets (Figure 6).

[Thomas Vierbuchen @TommyVierbuchen]

Excited to share our latest manuscript. This was an exciting collab with the (twitter-less) Matthias Stadtfeld + Jason Mezey labs at Weill Cornell. We examined the impact of genetic variation on pathological loss of DNA methylation in naive PSCs.

https://t.co/Kz3t9thMAm

[Thomas Vierbuchen @TommyVierbuchen]

Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation.

https://t.co/hYkW2fJ1qo

[Laura Santini @laura__sa]

https://t.co/miw0nF8abj