Excited to share our latest manuscript, a collaboration with @JustinPerryPhD led by @WeillCornell neuroscience PhD student @AnnBaako. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.
https://t.co/gTD7V4mSoz
🆕 publication! 🧬 How do enhancers, located far away in the genome, communicate with their target genes? In @MolecularCell, the lab of @chribue shows how different enhancers cooperate to drive gene expression using a novel synthetic platform ➡️ https://t.co/0Uz3XCNTei
👏🎉 Congratulations to Perutz alumna Laura Santini on receiving the Vienna BioCenter PhD Award! Her outstanding thesis focuses on a crucial cell state transition during early embryonic development 🧫➡️ https://t.co/rxyH9tij2T
Beyond excited to share my main postdoctoral work. We developed a robust mouse cortical organoid system, which recapitulates in vivo tempos and cellular diversity, and applied it to identify gene expression changes across subspecies during development. https://t.co/XQLx6TF3T2
🔬 Dr. Laura Santini (@laura__sa) and scientists at @univienna demonstrated that phosphorylated AKT acted as a 🚧 gatekeeper that prevented nuclear localization of FoxO transcription factors in naïve ESCs.
@NatureComms | https://t.co/vFzhIxq6L6
In sum, in our work we uncovered a previously unappreciated role for FoxO TFs in instructing formative identity. If this thread hooked you up, go check the whole article for more details!
I’m thrilled to finally see the main project of my PhD in the @leeboratory out in #NatComms. Congrats to all authors and collaborator @NRivron !
We identified FoxO transcription factors as crucial AKTors in the naïve to formative pluripotency transition.
https://t.co/dtkNOJhtgo
Finally, we forced FoxO TF nuclear shuttling by treating naïve and formative cells with an Akt inhibitor and observed a specific upregulation of core formative pluripotency genes which are FoxO1 targets (Figure 6).
Excited to share our latest manuscript. This was an exciting collab with the (twitter-less) Matthias Stadtfeld + Jason Mezey labs at Weill Cornell. We examined the impact of genetic variation on pathological loss of DNA methylation in naive PSCs.
https://t.co/Kz3t9thMAm
Excited to share our latest paper led by @rachelaglenn. We generated a genetically diverse mouse pluripotent stem cell panel from the Diversity Outbred stock and outline experimental approaches for "population-scale" in vitro directed differentiation.
https://t.co/hYkW2fJ1qo