How do chromatin modifications quantitatively impact gene expression?
How do sequence variants or combinatorial marks influence relationships?
We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵…
https://t.co/2p4W0J50Oc
We all take repeat annotation in the human genome for granted but are we sure it's correct?
In a 🚨new paper 🚨 from the lab, @xunchen85 shows that up to 30% of primate ERVs/LTRs instances are mis-annotated.
3 amazing papers just out @Nature, the kind worth giving up sleep for🦉
Spatial multi-omics human maps:
-placenta: MIBI & DSP
-intestine: CODEX & snRNAseq & snATACseq
-kidney: Visium & scRNA & scATAC
After sequencing single cells, we are now finally putting them back together🧵
Really happy that our paper on Obox, an oocyte/embryo-specific TF family including 8 members and over 60 copies in the genome, as a key regulator of mouse ZGA is now out in Nature!
https://t.co/FHd4rRyBA8
☕️NEW: Leung, Poon & co characterize transcriptomic and epigenomic changes at the maternal–fetal interface in patients with #COVID19, providing insights into aberrant pregnancy outcomes associated with SARS-COV-2 infection.
@Leung_lab_UST #SARSCoV2
https://t.co/MvdLL8Wcbz
Our paper is finally out in @NatureCellBio!
We profiled the maternal-fetal interface following SARS-CoV-2 infection. Congratulations to our PhD students @lingao02, @TamSabrina, @MellowMetal and collaborators on this work!
(https://t.co/sQjCOVYypn)
Here are my 12 guidelines for data exploration and analysis with the right attitude for discovery:
1. You never really finish analyzing a dataset. You just decide to stop and move on at some point, leaving some things undiscovered. 🧵
So excited to see our work on mapping human trophoblast in early pregnancy out in @Nature! I had the privilege of working alongside @krobertssci, @ktroule, @fredwck, @MSheridan226 and an incredible team on one of the coolest tissues @sangerinstitute https://t.co/cgomW3lA80
Thats a wrap for the @csi_singapore, @ntusbs and EpiHK Joint Virtual Symposium!
Thank you to everyone who participated and tuned in to the fascinating discussions and talks! 👋
The mystery of non-coding mutations in cancer continues. Mutations enriched at super-enhancers in the cell lines in which they are active and avoid negative regulators from binding ! Fascinating story
https://t.co/iu7PGM4RL7