Lin Guo

Assistant Professor, Dept. Biochemistry and Molecular Biology, Thomas Jefferson University. Protein Phase Separation in Neurodegenerative Diseases, ALS, FTD

[Lin Guo @LinGuo18]

Join us! A postdoc position is available in our lab to study the mechanism and regulation of liquid-liquid phase separation of RNA-binding proteins in the context of neurodegenerative diseases. For more information about our lab, please visit https://t.co/sNBEIzPSRw. Please RT.

[ShorterLab @ShorterLab]

Molecular determinants of Karyopherin-β2 chaperone and disaggregation activity, great to preprint this study led by @CharlotteFare with help from our wonderful collaborators @KevinRhine_ & @MyongLab2:
https://t.co/XvPrZQVZgO

[Janet Iwasa @janetiwasa]

.@MargotRiggi and I are excited to release "Phase Separation 101," a visual resource for undergrad teaching. Check it out here: https://t.co/gTP4KZyqfi and many thanks to the researchers and educators who gave us their invaluable feedback! A short preview below:

[Leeanne McGurk @LeeanneMcgurk]

Excited to share our ataxin-2 study. A combined effort from #boninilab that wouldn’t have been possible without @olivia_rifai!
Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence https://t.co/CblYVWu4Lc

[Brian Wallach @bsw5020]

My 5 year old’s friend asked her recently why her dad didn’t pick her up from school. She explained that I have ALS and it would take me forever to get there.

So today I surprised her and picked her up from school. Her reaction was e.v.e.r.y.t.h.i.n.g. (sound on).

[Alex Holehouse @alexholehouse]

Excited to share the final version of our new paper on the SARS-CoV-2 nucleocapsid protein, work done in very close collab with @AndreaSoranno's group. Congrats to 1st-author @jcubuk ( Soranno lab) and 2nd-author @JJAlston_ (Soranno/Holehouse labs) https://t.co/KSv1bTi5pS

[TweetALS @TweetALSMND]

Looking to study the role of #LLPS in #ALS #MND in vitro under conditions that are closer physiologically to #StressGranules?

@nchembio NMR and EPR reveal a compaction of the
RNA-binding protein FUS upon droplet formation https://t.co/MdiWmrbXjg

[Priya R. Banerjee @BanerjeeLab_UB]

If you are interested in Multiphasic Condensates and Liquid-Liquid Phase Separation of Multicomponent Mixtures, please check out our recent paper below!

[ShorterLab @ShorterLab]

Defining the diversity of HNRNPA1 mutations in clinical phenotype and pathomechanism: https://t.co/XKnupBim0G

[Ya-Ming Hou @YaMingHou1]

We have a postdoc position open immediately supported by NIH grants. We use a synthetic biology approach with CRISPR-edited genomes and CRISPRi approaches to determine how changes in tRNA epigenetics impact cell fitness in human health and disease. https://t.co/Y5sjf6VREI

[Priya R. Banerjee @BanerjeeLab_UB]

Excited to share our latest publication @BiophysJ "Quantifying Viscosity and Surface Tension of Biomolecular Condensates". Credit to @I_Alshareedah for a multiparametric approach using FCS, optical tweezers, and particle tracking.

https://t.co/awIbTO1l06

[Mae Staples Lux, PhD @MaeStaples]

Well this looks awesome...and out just in time for me to read before my thesis committee meeting tomorrow 😎 #condensatelife #transcriptionalregulation

[Lin Guo @LinGuo18]

Thanks, Charlotte!

[Lin Guo @LinGuo18]

Join us! A postdoc position is available in our lab to study the mechanism and regulation of liquid-liquid phase separation of RNA-binding proteins in the context of neurodegenerative diseases. For more information about our lab, please visit https://t.co/sNBEIzPSRw. Please RT.

[Lin Guo @LinGuo18]

@marcotrizzino Thanks, Marco!

[ShorterLab @ShorterLab]

G4C2 repeat–derived poly(GR) plays a key role in mediating TDP-43 mislocalization and aggregation in vitro and in vivo: https://t.co/TCJ8sRzWaG

[ShorterLab @ShorterLab]

Karyopherin-β2 Inhibits and Reverses Aggregation and Liquid-liquid Phase Separation of the ALS/FTD-Associated Protein FUS, nice methods paper from @LinGuo18: https://t.co/DJPGfhWme3

[ShorterLab @ShorterLab]

Glycine Rich Segments Adopt Polyproline II Helices Which May Contribute to Biomolecular Condensate Formation https://t.co/2PUWm3aFxG

[Shorter Lab Members @ShorterLabGroup]

Fluorescence Correlation and Cross-Correlation Spectroscopy Unveil Cytoplasmic mRNP Composition and Dynamics https://t.co/UytujiVr0o

[Priya R. Banerjee @BanerjeeLab_UB]

Pleased to share our "hollow condensate" paper that made its first appearance in @PNASNews today. We show that protein−RNA complexes can create lipid-free vesicle-like enclosures by phase separation.

@I_Alshareedah
@potoyangroup

https://t.co/GjAll9ac0t