Lioba Berndt

RA in Computational Psychiatry & Neuropharmacological Systems @UniofExeter • MSc Clinical Neuroscience @UCL • BSc Psychology @unipotsdam

[Jude Wells @_judewells]

Excited to announce the release of our open-source protein family language model, ProFam-1, designed to generate functional protein variants and predict fitness using in-context example sequences. 1/n

[Jude Wells @_judewells]

If you're interested in finding out whether these artisanal hand-crafted protein designs actually work: you can vote for my designs to be tested, by giving a ⭐️ here:
https://t.co/14hU5gjZT7

[Jude Wells @_judewells]

Ok let’s go @adaptyvbio binder design competition: this time designing proteins to neutralise the Nipah virus. Lots of great de novo ML binder design tools out there now, but this year I’m submitting an entry from TEAM HUMAN, seeing if pure rational design can win against the machines.

[Karl Friston News @KarlFristonNews]

Article: "Excitation/inhibition imbalance and conversion to psychosis in the clinical high risk syndrome:Biophysical modeling finds reduced pyramidal cell excitability across EEG paradigms"

First Author: @julia_rodsan

https://t.co/Ze6ISUcM9t

[Lioba Berndt @liobanause]

Huge thanks to @DrAlexanderShaw and @magnetokrishio for making this project possible!

[Lioba Berndt @liobanause]

🧠 Our new paper Restoring Synaptic Balance in Schizophrenia: Insights From a Thalamo-Cortical Conductance-Based Model is now published in Schizophrenia Bulletin.

[Lioba Berndt @liobanause]

Our in-silico restoration analysis suggests that coordinated changes across multiple receptor systems - rather than isolated alterations - may help remediate altered neural activity and align it more closely with healthy patterns.

[Lioba Berndt @liobanause]

We’re now busily back-translating to mice to test these predictions alongside some drugs that might help. 🐁

[Lioba Berndt @liobanause]

🧠 New pre-print out:
https://t.co/kPSkBo70az

[Lioba Berndt @liobanause]

In-silico pharmacological modelling suggests increasing NMDA receptor gain as a potential therapeutic target, implying NMDA receptor hypofunction as a key driver of sleep alterations in these high-risk individuals.

[Karl Friston News @KarlFristonNews]

Article: "A Canonical Microcircuit for Estimating Excitation/Inhibition (E/I) Balance"

Coauthors on X: @HopeOloye, @liobanause

https://t.co/y45r9zmb0z

[Alex 🇺🇦 @DrAlexanderShaw]

Testing an Active Inference agent in a 3D drone navigation task — it infers its own position and velocity from noisy observations, and selects actions by rolling out belief-based trajectories and minimizing expected free energy.

#ActiveInference #BayesianLearning #AI #AGI

[Alex 🇺🇦 @DrAlexanderShaw]

🚨 New preprint!

"Predictive Coding and Neurocomputational Psychiatry: A Mechanistic Framework for Understanding Mental Disorders"

read it: https://t.co/Or9maLfdbB

[Julia Rodriguez-Sanchez @julia_rodsan]

Some news... This week I passed my PhD viva with no corrections! A big thank you to my examiners @KathaSchmack and @magnetokrishio for such an inspiring discussion, and to my amazing supervisors @dr_rick_adams, @DanHauke and Karl Friston for all their support throughout my PhD!

[Lioba Berndt @liobanause]

@DrAlexanderShaw @magnetokrishio Rather than just focusing on differences, we identify specific synaptic changes across neurotransmitter systems - exploring quantifiable targets for potential therapeutic interventions.

[Lioba Berndt @liobanause]

@DrAlexanderShaw @magnetokrishio Our restoration analysis quantifies which neural circuit parameters need adjusting to align power spectrum density in schizophrenia with healthy controls.

[Alex 🇺🇦 @DrAlexanderShaw]

New preprint !

"Restoring Synaptic Balance in Schizophrenia: Insights from a thalamo-cortical conductance-based model."

https://t.co/6fXZJ6fk55

with @liobanause and @magnetokrishio.