David Mai

@fredhutch @uwproteindesign | made via @hprscholars @pennbioeng @berkeleybioe

[David Mai @lococyte]

@budapp 🪷

[Nick Desnoyer @NickDesnoyer]

My poster on flower bioengineering at the #AIEBaB26 conference in Bristol last week 🌹 🧬 ✨

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[Jacob Schreiber @jmschreiber91]

In the genomics community, we have focused pretty heavily on achieving state-of-the-art predictive performance.

While undoubtedly important, how we *use* these models after training is potentially even more important.

tangermeme v1.0.0 is out now. Hope you find it useful!

[Nick Desnoyer @NickDesnoyer]

Introducing the 1,000 Flower Collection 🧬🌹

I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes.

Here’s how I’m making it happen…  and how you can join me on this journey 🧵(1/7)

[Charles Swanton @CharlesSwanton]

ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in @Nature https://t.co/TnMno4AZhU

[Josh Tycko @JoshTycko]

Our new paper on epigenome editing is out!

We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability

https://t.co/VqRLtNFey7

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Literature is awarded to the South Korean author Han Kang “for her intense poetic prose that confronts historical traumas and exposes the fragility of human life.”

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[Ivan Alcantara @ivancalcantara]

My PhD work is out!

How do mothers balance tending to their own needs, such as eating, and taking care of their offspring? We examined the link between feeding and parenting neural circuits and how they are modulated postpartum in mice 🧵 (1/9)

PREPRINT: https://t.co/ICINJIAb5u

[Jonathan Kagan @jkagan1]

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome.
https://t.co/J9xnnt0xXD

[David Mai @lococyte]

@xinchen_w @RLCscienceboss @endpts @pablolubroth @HummingbirdVC congrats to you and david!

[Nicholas Perry @ntperry13]

Our work on bridge recombination is out in @Nature today. We are especially excited to share our structural work in collaboration with @hnisimasu. We show that this enzyme makes and breaks a Holliday junction, using more (!) RNA-DNA base-pairing to drive the reaction forward 🧵

[Matt Durrant @mgdurrant]

Our 2 bridge RNA papers are finally published in @Nature! Check out the incredible CryoEM structures, they're truly beautiful. A years-long rollercoaster ride, it's hard for me to imagine a more exciting project than this. Thank you to @ntperry13, @pdhsu, and our amazing team!

[hnisimasu @hnisimasu]

Happy to announce that two papers on the bridge RNA-guided IS110 recombinase have been published in Nature! Many thanks for the wonderful collaboration with @pdhsu.
https://t.co/vcaZZmCRs6
https://t.co/YzTVpegjrh

[Edwin Neumann @EdwinNNeumann]

Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
https://t.co/DrV4EGe92z

[Kole Roybal @KoleRoybal]

Read below about our exciting work that is now out
@Nature led by @jcole_garcia of @UCSF @parkerici
@GladstoneInst and @jay_daniels1 of
@NUFeinbergMed. This is one of the most gratifying collaborations with @jaehyukchoimd
-- https://t.co/47WuaFEJUO

[Rongzhen Tian @RZTian_Alvin]

Excited to share - EcORep! Now you can simply electroporate a PCR product into E. coli and let the linear DNA replicate orthogonally in the cell. EcORep can be used to evolve proteins rapidly and continuously! https://t.co/jzIRnci3Jf