Boris Djordjevic

Entrepreneur, Investor & futurist advancing longevity, partial reprogramming & preventive medicine.

[Boris Djordjevic @longevityboris]

@BBNTimes_en I've seen her talk about AI and I'm just as impressed of her as a speaker and entrepreneur!

[Boris Djordjevic @longevityboris]

OpenAI built GPT-4b with @RetroBio_ to optimise OCT4 reprogramming.

199 Bio is working on the same problem.

@sama, would you open it up more broadly?

[Boris Djordjevic @longevityboris]

@xeniatchoumi Wow wow! You're welcome 😍🥰

[Boris Djordjevic @longevityboris]

Digital creators are pivoting from luxury into AI and tech.

@xeniatchoumi at Cannes this week is one of the cleaner examples.. buried in this piece is her move into AI and digital entrepreneurship.

Who else is doing both lanes at once?

[BBN Times @BBNTimes_en]

Xenia Tchoumi made a highly visible return to the 79th Cannes Film Festival this year as an official guest of Campari, continuing her long-standing positioning at the intersection of luxury, business, fashion, and modern digital entrepreneurship. https://t.co/qXYs29ydrE

[Avi Roy @agingroy]

Retatrutide. 28.3% weight loss. 70 pounds average. TRIUMPH-1 Phase 3, published yesterday.

Every headline says “triple agonist.” Almost none explain why the third receptor changes everything.

Ozempic and Mounjaro suppress appetite. That’s the GLP-1 and GIP part. Retatrutide adds a glucagon receptor. Glucagon doesn’t kill your hunger. It raises your resting energy expenditure. Your body burns more calories doing nothing. Two fronts: eating less AND burning more.

That’s why retatrutide posted 28.3% vs Mounjaro’s 22% vs Ozempic’s 15%. The gap is in the mechanism.

Phase 2 showed 24%. Phase 3 beat it. The high-BMI group lost 85 pounds over two years. Nearly half of all participants lost more than 30% of their body weight.

I ranked 9 drugs chasing Ozempic’s market a month ago. Retatrutide was #2. The full pipeline, with every mechanism and timeline, is below.

[Boris Djordjevic @longevityboris]

The thing I love most is going deep into many fields at once, then watching the connections appear between them. AI has just made that possible at a scale we never could have imagined

[Boris Djordjevic @longevityboris]

https://t.co/MAoQl3DbpC

[Boris Djordjevic @longevityboris]

https://t.co/MAoQl3DbpC

[Boris Djordjevic @longevityboris]

Vaccines that protect against Alzheimer or Dementia -- this is only the beginning.

[Avi Roy @agingroy]

The strongest evidence-based tool for preventing Alzheimer’s and dementia may already be sitting in your shot record.

104 million people. 8 vaccines. All showing protection against brain diseases they were never designed to prevent.

Ranked by how much they lower Alzheimer’s and dementia risk:
→ Shingrix (shingles): 47% lower Alzheimer’s risk. Meta-analysis, 104 million people (Age and Ageing 2025). A separate Wales natural experiment (Nature 2025, n=280,000) confirmed a 20% dementia reduction independently.

→ Pneumococcal: 36% lower Alzheimer’s risk. People carrying the APOE risk gene saw a 25-30% reduction in a separate study of 5,146 people.

→ Tdap: 33% lower dementia risk. Same 104-million-person meta-analysis.

→ RSV (Arexvy): 29% lower dementia in 18 months. This vaccine was approved in 2023. It’s one of the newest vaccines in existence, and it’s already generating a brain-protection signal nobody predicted.

→ Influenza: 26% lower Alzheimer’s risk with 1+ year of consecutive annual shots (JAMA 2024).

→ Hepatitis A: 22% lower dementia risk. Same 104M meta-analysis.

→ Hepatitis B: 19% lower Alzheimer’s risk. Observational, n=50,000+.

→ HPV: 31% lower infection-associated cancer risk (JAMA 2023, n=1.4 million women).

All insurance-covered. Most free at any pharmacy.

The hypothesis connecting all eight is that every infection leaves behind a trace of inflammation. Over decades, that chronic low-grade fire accelerates neurodegeneration. Vaccines reduce the number of infections your brain has to weather across a lifetime.

Your vaccine schedule was already an Alzheimer’s prevention protocol. Nobody framed it that way until now.

[Boris Djordjevic @longevityboris]

I've built for myself very valuable helpers, e.g. CLIs or agent skills across several github accounts and orgs. They've been immensely helpful. I've built a CLI for managing X that's far above any other product or paid SaaS; there's been little traction. On the other hand, getting thousands of github stars then promoting your tool creates just so much more traction and adoption, it just doesn't make sense not to do it.

If I cared about people using what I built, getting more stars to support my application to work at Anthropic or raise money for a specific project, I would totally buy stars. I don't. Anyhow, on X, you can boost your posts. On github, you can't bost your repos. *wink* hidden opportunity *wink*

[Boris Djordjevic @longevityboris]

@CGrovesNLN If it's in context of power/strength/fatigue, albeit a different mechanism, I've had success with acetylcholin precursors (particularly alpha GPC)

[Boris Djordjevic @longevityboris]

Genuine question: what's a thing you've been trying to find or figure out for weeks/months and just can't get a clear answer on?

[Boris Djordjevic @longevityboris]

@Gazucillo coincidentally I'm working on it

[Boris Djordjevic @longevityboris]

@0xSero @badlogicgames Wasn’t Claude (and codex) scrambling and breaking the logs to protect themselves against distillation, from the earlier source code leak?

[Boris Djordjevic @longevityboris]

@martianwyrdlord For certain people with high risk variants of the ApoE gene, eating meat actually reduces the risks of dementia or co hmm cognitive decline. Higher protein intake is also strongly linked with less frailty. This is not promoting health, but political and social agendas.

[Boris Djordjevic @longevityboris]

@AJamesMcCarthy Given the amazing work you’ve been doing I’m sure @elonmusk might sponsor your ticket for that trip.

[Boris Djordjevic @longevityboris]

@aykutuz @agingroy @pesottas On the other hand, if we look at autoimmune conditions...

[Boris Djordjevic @longevityboris]

@Ashwinreads Every once in a while, it's good to have something to reframe your perspective on money, and what it does to us and how it can help us. Nice light reading.

[Boris Djordjevic @longevityboris]

I’ve went from mostly Claude to mostly Codex last week to a rough 50/50 since yesterday. With each new version you need to adapt to different mechanics and personality quirks. Claude is more controllable and often I need precision over smaller iterative steps rather than Codex doing beautiful and amazing job AND hallucinating 10 features I didn’t need then spend the time removing stuff.

[Boris Djordjevic @longevityboris]

@EricTopol Tried a device by a company called Airdoc that does AI fundus analysis -- they had access to national data from China and built predictors for most diseases. Correlations, not causations, but still interesting and IMO a missed opportunity due to extremely low cost of testing.