Longfei Wang

structural biochemistry | molecular pharmacology | immune signalling | RNA biology @bcmpharvardmed @bostonchildrens @wuhanuniversity

[Longfei Wang @longfei_wang]

@rafapinilla92 @ScienceMagazine Congrats!

[Prof. Hao Wu @WuLabHarvard]

What an exciting news and a huge honor! Our 2014 paper on ASC-PYD inflammasome filaments (Lu et al., Cell) has been recognized as a landmark in Cell’s "2014–2024 Timeline"! 🔥🔥🔥 #Inflammasome #PYD #StructuralBiology
🔗 https://t.co/j2O3xmbZLP

[Longfei Wang @longfei_wang]

so cool!

[Max Wilkinson @maxewilkinson]

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses.

(👇 I recommend sound ON for the video 🎹)
1/

[Longfei Wang @longfei_wang]

@abrahamlabhms @HHMINEWS @HarvardMicro @BlackInMicro @HarvardMITmdphd Congrats!! Well-deserved

[Boston Celtics @celtics]

2024 WORLD CHAMPIONS 🏆

[Longfei Wang @longfei_wang]

@rafapinilla92 @FabBenz @SarahCamara94 Congrats!

[Li Zexin 李泽欣 @XH_Lee23]

Here is a testing video of BYD’s revolutionary new car:
🔹From Xi’an to Changchun (the map is from my phone). No refueling, no recharging.

🔹Final range: 2409.5km (higher than the instructed 2100km)

🔹Follow the normal driving habit. AC on, rainy weather, no deliberated low-speed driving for saving fuel.

No wonder America banned China’s cars. This car will kill all competitors. Don’t forget it costs only $13,800 - $19,300.

[Cornelius Gati @CorneliusGati]

I am delighted to announce that we are hosting the 9th SoCal CryoEM Symposium, Oct 11th 2024 @USC @USCBridge in LA. We are especially excited about our keynote speaker - the one-and-only Prof. Hao Wu @WuLabHarvard. Registration is free. Spread the word! https://t.co/hXbCTeAOCp

[Longfei Wang @longfei_wang]

@rafapinilla92 @g1_guillermo @thenielsenlab @ArturoCarabias @SarahCamara94 @pentamorfico Congrats!

[Longfei Wang @longfei_wang]

@AlexanderSobol6 @shantigangwar @MariaKarela3 @knadezhdinPhD Beautiful, congrats!

[Pushmeet Kohli @pushmeet]

We love the excitement & results from the community on AlphaFold 3 and are doubling the AF Server daily job limit to 20. Happy to also share that we're working on releasing the AF3 model (incl weights) for academic use, which doesn’t depend on our research infra, within 6 months.

[Rowan Cheung @rowancheung]

12. Improved image recognition and the ability to interpret faces ata really high level (lol) https://t.co/P5HOejWvpL

[Longfei Wang @longfei_wang]

@jpkbravo @ISTAustria Congrats!

[Stephanie Wankowicz @stephanie_mul]

We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in @Nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. https://t.co/8fOYWffXLv

[Ying Dong @yingdong01]

Ever wondered how different caspases select their substrates? Turns out, they have their own styles. Check out our study: https://t.co/a27xIZX6oC @ImmunityCP Cheers to the fantastic teamwork! @jkagan1 @LEK_Lab @WuLabHarvard. ����🧵(1/7)

[Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social @RolandDunbrack]

In my review, I made a list of much science that happened bc AlphaFold2 code was released. I suggested that so much science will not happen if AlphaFold3 code is not released (or not with AF3 itself). We've made ~100k models with AF2 code. How could we use a server for all that?

[Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social @RolandDunbrack]

@pedrobeltrao As a reviewer #3 of the paper, I tried REALLY HARD to get @Nature to demand downloadable code. The editors just ghosted me. I wrote extensively that the server needed work but I was not given the paper to re-review so I don't know if they improved it. It's not available yet.

[Longfei Wang @longfei_wang]

I think the license of PDB should be changed, structural biologists deposit structures for free but have to pay to use the AI models that were trained on our data..

[Martin Pacesa @MartinPacesa]

Although it is a very exciting development, it is sad to see that no code will be released, which would not be allowed for academic institutions @nature. It was clear that weights will not be released (despite being trained purely on public data) but this I did not expect.

[ElowitzLab @ElowitzLab]

Our new paper on “synpoptosis” circuits, led by the amazing @ShiyuXia, is now out: https://t.co/OuVWIVCbE9 (1/3)

[Longfei Wang @longfei_wang]

A small E2 protein mimics the ubiquitin cascade in a CBASS antiphage system. We struggled for so long to figure it out and are very happy to see it finally published in @NatureMicrobiol

[Nature Microbiology @NatureMicrobiol]

OUT NOW Phage defense system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway https://t.co/EiPm8z517L