Loukas Papargyris

Research Associate. Respiratory viruses & vaccine immunology.
Also at

[Loukas Papargyris @lpapargyris]

Excited to see our work published in @NatureMedicine📚
'Innate immune responsiveness predicts enhanced cellular immunity and symptomatic disease after controlled human influenza infection.'

Using #controlledhumaninfection @ChrisChiuLab with #influenza, we longitudinally analysed the immune profiles of healthy adult volunteers. Early #innate immune responses post-infection correlated with higher symptom scores and cellular immunity later. This revealed a pattern of quicker and greater immune activation to which individuals who proceed to #symptomatic disease are predisposed at the point of virus exposure. Read more here: https://t.co/t7xTWRJU6W

Many thanks to study participants, co-authors, collaborators, colleagues, reviewers, editors and funders that contributed to the accomplishment of this work, with implications for #biomarkers, #vaccines and host-directed #therapies.
Please repost!
https://t.co/LcXVAPamrm

[Loukas Papargyris @lpapargyris]

Excited to see our work published in @NatureMedicine📚
'Innate immune responsiveness predicts enhanced cellular immunity and symptomatic disease after controlled human influenza infection.'

Using #controlledhumaninfection @ChrisChiuLab with #influenza, we longitudinally analysed the immune profiles of healthy adult volunteers. Early #innate immune responses post-infection correlated with higher symptom scores and cellular immunity later. This revealed a pattern of quicker and greater immune activation to which individuals who proceed to #symptomatic disease are predisposed at the point of virus exposure. Read more here: https://t.co/t7xTWRJU6W

Many thanks to study participants, co-authors, collaborators, colleagues, reviewers, editors and funders that contributed to the accomplishment of this work, with implications for #biomarkers, #vaccines and host-directed #therapies.
Please repost!
https://t.co/LcXVAPamrm

[Spyros Lytras @SpyrosLytras]

Come work on exciting AI for biology projects in Paris!! 🇫🇷

Details and application below, deadline sept 1st!

[Nature Medicine @NatureMedicine]

⚡ Our July issue is out! Featuring new research on #neuroprosthetics (see cover), #e-cigarettes, #bispecific drugs in #cancer and #HIV, #Lassa fever vaccines, #GLP-1s, #siRNAs and much more including reviews, news and opinion.
Read it here: https://t.co/zprsvDIXg0

[Loukas Papargyris @lpapargyris]

https://t.co/cMUW2xtmKl
#HumanChallenge #Influenza #ImmuneResponse #InnateImmunity
@ChrisChiuLab

[Dr Claire Smith @Dr_ClaireSmith]

Delighted to share our new paper, out now in @NatureComms where we show that neutrophil myeloperoxidase (MPO) tracks RSV severity in infants, and can be used as a functional readout of therapeutic efficacy in the lab.

📄 Read it (open access) 👉 https://t.co/bhsSMc9CaQ

[Eric Topol @EricTopol]

To get better protection against respiratory infections and transmission we need to achieve nasal immunity. A new @ImmunityCP review https://t.co/i1CPx5VTpH

[Prof. Akiko Iwasaki @VirusesImmunity]

New preprint by @alex_winnett @S_Tabachnikova et al.! We asked: which cellular immune signals control viral replication in the nose during the first days of SARS-CoV-2 infection — and how do they change with vaccination? With @ismagilovlab (1/)
https://t.co/HIpMpvahDc

[MUSICC @MUSICCproject]

💉 Help advance COVID-19 research

We’re studying SARS-CoV-2 infection in healthy adults aged 18–50.

The study includes pre-screening, screening, quarantine, and 4 follow-up visits.

💷 Paid up to £3,935
📍 Locations: London, Oxford & Southampton.
🔗 https://t.co/MGVnp3MSD3

[Adriana Tomic @TomicAdriana]

A must-read in @NatureMedicine ! 🔬 @ChrisChiuLab & team show how baseline innate immune state dictates #flu #ViralClearance. Brilliant #HumanChallenge study! 👏🧬👇

[Florian Krammer @florian_krammer]

Nico Halwe just published a nice review about the H3N2 pandemic of 1968. Worth reading!

Vaccine strategies and development before and during the 1968 H3N2 influenza pandemic
https://t.co/7KChx7oOqa

[Waggoner Lab @LabWaggoner]

Review @SciImmunology @E_v_a_Kaufmann @MazDivangahi @mcgillu
Innate immune memory is reviewed as a life-span adaptation shaped by evolutionary origins, epigenetic-metabolic mechanisms, and the exposome
https://t.co/5o6vHu1Oyc

[Adriana Tomic @TomicAdriana]

Why do some get sicker from the #flu? 🦠 Amazing work by @ChrisChiuLab showing quicker #innate_immune activation at exposure predisposes individuals to symptomatic disease, but also stronger #cellular_immunity! 🔬��� Read here:
https://t.co/XOUYZ5AEpR

[Adriana Tomic @TomicAdriana]

The systemic response doesn't tell the whole story. 🩸 ≠ 🫁 👃
Lower airways are a critical step, but the ultimate frontier is the site of viral entry: the #UpperRespiratoryTract #Mucosal_immunity
​The tissue is where the answers are! 👇

[Waggoner Lab @LabWaggoner]

Human innate cell responsiveness is a predeterminant of both symptomatic disease and cellular immune responses known to promote viral clearance @NatureMedicine @imperialcollege @lpapargyris
https://t.co/Go9hRQZRtC

[lolos marios @lolosmarios]

The full moon, known as the Strawberry Moon, rises over the Temple of Poseidon on Cape Sounion near Athens, Greece, on June 29, 2026.
#fullmoon

[Science Magazine @ScienceMagazine]

A vaccine that could provide protection against multiple pathogens would be invaluable, particularly during pandemics in which knowledge of the causative pathogen is limited.

In a new Science study, researchers found that a nasal vaccine designed to stimulate innate immune cells and T cells provided protection against both viral and bacterial lung infections in mice. https://t.co/SErpKv9RrB

[Richard Dawkins @RichardDawkins]

Fifty years ago, The Selfish Gene was published. The ideas — replicators, memes, the gene's-eye view of life — have held up rather well. The 50th Anniversary Edition is out now.
Available at: https://t.co/UUpOxy2MTa