Gastric Cancer: A Comprehensive Update (JAMA, 2026)
Gastric cancer management has decisively shifted from anatomy-based staging to molecularly driven precision medicine.
Reference:
Patel AK, Sethi NS, Park H. Gastric Cancer: A Review.
JAMA. Published online January 7, 2026.
https://t.co/kJ9MUMDIsi
#GastricCancer #PrecisionOncology #GIOncology #ClinicalPractice
🌟 NorthStar #ESMO25
Adding local consolidative therapy (LCT) to osimertinib in EGFR+ metastatic NSCLC boosted outcomes 💥
📊 mPFS: 25.3 vs 17.5 mo (HR 0.66, p = 0.025)
💪 Benefit in both ≤3 & >3 mets
🧬 Ex19del 39.8 vs 22.4 mo | L858R 19.0 vs 11.0 mo
🩺 No added toxicity
✅ Takeaway: Osimertinib + LCT = longer control, same safety
#OncoTwitter #MedTwitter #LungCancer #ESMO25 @myESMO@esmo_open@OncoAlert
Chemo-IO vs IO in patients with stage IV NSCLC: an FDA pooled analysis from 12 studies (n=9084): No difference in OS between chemo-IO and IO arm. Older adults (>=75 years) may have better OS and PFS with IO. Limitation of the study: Exploratory #LCSM#ASCO22@OncoAlert
27 Sep – 1 Oct 2013 | Amsterdam, Netherlands ESMO-ECCO Supported by Eli Lilly and Company. Eli Lilly and Company has not influenced the content of this. - ppt download https://t.co/EtB84UrK8J
Overview of Targeted Therapies for Esophageal and Gastric Cancers Johanna Bendell, MD Director, GI Oncology Research Associate Director, Drug Development. - ppt download https://t.co/w3rUNUNqcp
I agree @pashtoonkasi
I have a number of patients with upper GI cancers w MSI high tumors who after only 1 year of AntiPD-1 tx (then stop) with CR are now on surveillance for several years and essentially cured. Would not do surgery in somebody that fits this story line.