LYACTS-CIRI

LYmphocyte ACtivaTion and Signaling.
Team leader Dr Thierry Walzer

[Plassart Samira @SamiraPlassart]

📢 SAVE THE DATE! RHUMATOPEDIES 2024 is coming
📅Wednesday 4th December 2024
📌 University of Lyon, 69007 LYON
👨‍⚕️ Lecture by Prof. Daniel Kastner, MD, PhD
📝 Registration: https://t.co/NsfqFNuTfn
📰 Scientific Programme below

[Waggoner Lab @LabWaggoner]

6 novel monoallelic PTPN2 mutations in pediatric lupus and Evans syndrome that cause T cell hyperproliferation and high inflammatory cytokines @JExpMed
https://t.co/ODOu1XBd80 @MACattackLab comment
https://t.co/YCuJo3GdY1
@AlexandreBelot @FRLab1 #Mathieu

[JEANPIERRE Marie @MarieJeanpierr]

Very proud to share my first paper on my thesis project, a great collaborative effort between @CIRI_Lyon and @InstitutImagine, now published in @JExpMed. Check it out!

[Jade Cognard @CgdJade]

Honored to have been part of this beautiful collaboration with @JEANPIERRMarie from @FRLab1 team in @InstitutImagine for my very first steps in the lab, thanks to @lyacts, @MaudTusseau @AlexandreBelot and Anne-Laure Mathieu ! ✨´

[LYACTS-CIRI @lyacts]

Thrilled to share our work on PTPN2 mutations in autoimmunity. Congratulations to all authors on this beautiful study! A great collaborative effort between @FRLab1 team at @InstitutImagine and @AlexandreBelot's team at @lyacts @CIRI_Lyon
@CgdJade @MaudTusseau @ALMathieu277161

[Journal of Experimental Medicine @JExpMed]

Jeanpierre, Cognard, @FRLab1, @AlexandreBelot, Mathieu @CIRI_Lyon et al. performed exome sequencing in pediatric systemic #lupus and Evans syndrome and identified six novel monoallelic PTPN2 mutations, impairing its regulatory function. https://t.co/O0FZoTSok7
#autoimmunity

[Casanova Lab @casanova_lab]

Excellent review on monogenic SLE:
https://t.co/TxP6wrL2gl

[Belot Alexandre @AlexandreBelot]

Mendelian causes of autoimmunity -> the #lupus phenotype! A fascinating (disease) syndrome #IEI, #RareDisease #Genetics with @MaudTusseau @SamiraPlassart @CgdJade @SarahBenezech @LilianeKhoryati @Seb_Viel @FRLab1 @lyacts, Still so much left to uncover.

[CIRI Lyon @CIRI_Lyon]

Ce 29 février, c'est le #RareDiseaseDay2024.

Au CIRI, les équipes I2BA (T. Henry) et LYACTS (T. Walzer) étudient des maladies rares auto-immunes et auto-inflammatoires.

Un grand merci aux cliniciens qui font avancer la recherche, et aux patient/es !

[CIRI Lyon @CIRI_Lyon]

❔Quel est le lien entre cancer et système immunitaire ?

Thierry Walzer, directeur de recherche @Inserm et chef de l'équipe @lyacts, l'explique dans l'émission #TêtesChercheuses, dont voici un extrait 👇

Retrouvez l'émission complète ici ➡ https://t.co/sjxD0wRHqI

[Belot Alexandre @AlexandreBelot]

🔬 🌐 Check out our comment on drug development in ultra-rare diseases in @TheLancet, spotlighting promising results of a new C5 inhibitor via SC route for CD55 deficiency. 🩺 #RareDiseases #MedicalBreakthrough"https://t.co/sMr1r4fuEU ⤵️

[Kate Webb @drkatiewebb]

Fascinating paper on pre-covid possible MIS-C with implications for understanding pathogenesis. Congrats Alex Belot and team. Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children | NEJM https://t.co/oUydODNpuy

[Belot Alexandre @AlexandreBelot]

Fantastic research day at Rhumatopedies 2023, the 10th edition that welcome in Lyon many talented young researchers in the field of Pediatric Immunology/rheumatology & Incredible talk of our guest @BrodinPetter! Thanks for coming

[Belot Alexandre @AlexandreBelot]

History of a success: exciting science, friendship and Cuisine Lyonnaise. @BrodinPetter #Rhumatopedies2023

[Johan Van Weyenbergh @johanvawe]

Sometimes groundbreaking research means demonstrating there nothing new but we missed it before! 'Old' Coronaviruses were triggering MIS-C in children before #SARSCoV2 👇👇👇
#pandemicpreparedness

[Christoph Kessel @ChristophKessel]

Beautiful work from @AlexandreBelot and team on MIS-C assigned to the pre-COVID area, including TCR Vb21.3 expansion! https://t.co/vfvyD7dkdY

[Shen-Ying Zhang @ShenYingZhang1]

MIS-C existed pre-COVID? See this report from @AlexandreBelot and colleagues. Time to re-think about Kawasaki disease and other post-infectious inflammatory conditions.

[NEJM @NEJM]

Correspondence: Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children https://t.co/vC1T9z1HTV

#Pediatrics

[HCL | Recherche en santé @HCL_research]

COVID-19 : le syndrome inflammatoire multi-systémique de l’enfant (PIMS) existait avant la pandémie https://t.co/iAZv6Xe0zC @CHUdeLyon @CIRI_Lyon (@UnivLyon1 @ENSdeLyon @InsermAuRA @CNRS_dr07)

[NEJM @NEJM]

A study suggests that prepandemic and SARS-CoV-2–negative cases that are indistinguishable from MIS-C are characterized by Vβ21.3+ T-cell expansion and may be triggered by other pathogens. Read the full correspondence: https://t.co/vC1T9z1a4n

[Belot Alexandre @AlexandreBelot]

Thrilled to share our paper in @NEJM on pre-COVID and SARS-CoV-2 negative MIS-C. This condition predates the pandemic but was incredibly rare and often misdiagnosed as Kawasaki Disease Shock Syndrome or Toxic Shock Syndrome without identified bacteria https://t.co/ADSsYrVazj 🧵