ICIs can cause 2 distinct optic neuropathies 👁️
🔹 Papillitis – often with uveitis/VKH, better prognosis; ICIs may be resumed after recovery
🔹 Optic neuritis – linked to broader neurotoxicities, poorer outcomes (persistent deficits in up to 80%)
Full text
https://t.co/4CgYbT1QFd
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Practical recommendations for diagnosis and management by the NINA Group @GruppoNina 🇮🇹 - Journal of Neuroimmunology https://t.co/JpSS8EFLMD
Thank you to @MS_Australia for this great piece.
➡️ COVID-19 VAX boosters improve the longevity and cross-variant breadth of immune responses in #MS
➡️ machine-learning models predict protection or need of an extra booster.
@anneke_vdw@darshi_r@StuartTurville@syd_health
1/5 The long-awaited 2024 McDonald criteria are now published! I’m proud to see that our work at @UCLIoN@UCLHresearch has helped to change the way MS is diagnosed, and that our patients will now benefit from earlier diagnosis and treatment @olgacicc
https://t.co/6jRaFnSaAT
Happy to share our new work just out in JNI. We found that neuropathic pain isn't just common in CASPR2 antibody disease, but it can be the only symptom. The good news? Immunotherapy often works.
👉 https://t.co/NcrGmPnMhf
Our new editorial is out: Optimizing Treatment of Severe Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease Attacks: It's Time to PLEX! | Neurology https://t.co/Y7qu0XnPyx @SaraMariottoMD 🇮🇹
A fantastic course organized by @RosaCortese5 and Alvino Bisecco, featuring brilliant speakers and some of the best students.
AINI Summer School
Neuroimaging in Neuroimmunology
Siena – 17–18 July 2025
The charm of the Tuscan landscape was the cherry on top!
@GruppoNina
#CASPR2-#antibody diseases are provide clues to mechanisms of autoantigen-specific tolerance
Here - in @ScienceAdvances - we show how central and peripheral B cell tolerance licences pathogenic CASPR2 antibody generation.
https://t.co/lmXB9fcHBy
More below 👇🏿
🌍🇮🇹💝 Esperti da tutta Italia si uniscono per augurare a tutti un felice Mese della Consapevolezza su #NMOSD e #MOGAD!
📢 Marzo è dedicato a NMOSD, mentre aprile sarà il mese di MOGAD. Un’occasione per sensibilizzare, supportare la ricerca e dare voce ai pazienti.
https://t.co/ZJHaeghpzv
Proud to share @StefanoMascio91 latest work on PLP1 antibodies in demyelinating diseases. PLP1 abs are mainly found in patients with non MS diseases with combined central and peripheral demyelination, but also in rare seronegative NMOSD
The benefits of early initiation of disease-modifying therapy in MS are well-established, but when & how to de-escalate treatment remains unclear. Androdias et al. summarise findings from an ECTRIMS workshop on this topic and propose practical guidelines. https://t.co/J35eUKZQ6H
Great piece by @tompollak —worth reading. While a small minority of patients with psychiatric disorders (rarely isolated) have an autoimmune basis like AE, most do not. Using immunosuppressants outside Ab-positive AE is risky and often ineffective
https://t.co/qWPGm3Nqmy
Delighted to share @dinoto_ale et al study on the rare cerebellar attacks in #NMOSD attacks: ➡️ Often coexist with brainstem attacks ➡️ MRIs with peduncle or dentate nucleus lesions ➡️ Should be incorporated in upcoming 2025 #NMOSD diagnostic criteria 👇 https://t.co/rvTM7t5xmC