MDecker

[CharlieIntel @charlieINTEL]

First teaser trailer for Modern Warfare 4's new Kill Block multiplayer map

[y @ysuckme]

Spain is moving like prime 2010 Spain.

[Dan Go @CoachDanGo]

A visible bicep vein is a bigger status symbol than an expensive car.

[MDecker @m_dkit]

@stats_feed We like em when their 40 🤭

[Nicolas Hulscher, MPH @NicHulscher]

A new study found sunlight PASSES THROUGH the human body, RAPIDLY boosting mitochondrial function and improving vision.

Just 15 minutes of fully clothed infrared sunlight exposure triggered measurable improvements in vision 24 hours later.

[Gary Vaynerchuk @garyvee]

You are insecure. And that is why you are not doing your thing. You are worried if you fail what they will think and what they will say.

The reason so many people are afraid to put out content, start the business, ask for the promotion is because they are afraid of being judged. The judgment of others has crippled too many of you.

Please feel safe. You can do this!!

[Coinvo @Coinvo]

UPDATE: Possible GTA 6 domains have been discovered.

BuckMe is their Cash App.
RydeMe is their Uber.
WhatUp is their WhatsApp.
LeonidaGov is the state government website.

[Bryan Johnson @bryan_johnson]

let me cook

[Bryan Johnson @bryan_johnson]

People are sleeping on how fast solving death becomes humanity's focus.

[Gary Vaynerchuk @garyvee]

The American Dream is not big houses and cars. The American Dream is waking up every day with a lack of anxiety in your chest.

[Bryan Johnson @bryan_johnson]

breakfast

red lentils, carrots, onion, celery, vegetable broth, mushrooms, parsley, oregano, garlic, cauliflower, arugula, parsley, cilantro, extra virgin olive oil, red wine vinegar, red chili pepper, balsamic reduction, sesame seeds as garnish

[Bryan Johnson @bryan_johnson]

Breaking news for people who want to look hot, be young and not die. 

A few years ago, two college dropouts told me they could accelerate longevity by building a faster AI chip. 

I invested, and they just pulled it off.

What it means:

> 10x more throughput (tokens per second) for the same power footprint

> Dramatically lower operational costs for executing today’s frontier models

> Run far larger, more capable AI models within the same power and thermal budget, because a transformer-specific chip spends a fraction of the energy per token that a general-purpose GPU does

Rob and Gavin's approach resonated with me because solving aging is a gigantic combinatorial search problem. The chemical space of small, drug-like molecules has around 10^60 possibilities.

These compounds need to be mapped against a human proteome derived from 20,000 genes, including 1,600 transcription factors, and a dense web of interactions among them. 

The size of the combinatorial space is problematic. You need to identify which targets to modulate, within specific cellular lineages, at exact dosages, and in optimal temporal sequences.

Traditional high precision physics simulations are too slow to brute force the problem. You can shortcut it with AI inference, using frontier neural networks as hyper fast surrogate models to predict biological interactions instantly. By hardwiring transformer logic into silicon, Etched offers the infrastructure needed to run these massive biological foundation models at scale.

I'm surprised and impressed they were able to pull this off, and so quickly. 

They already have $1B in orders

[MDecker @m_dkit]

@shubhvanii it’s all a curse if you’d behaved correctly at all times

[Fitness Harbor @FitnessHarbor_]

High cortisol cuts 7 years off your life, tanks libido, destroys your sleep, increases body fat and literally melts your brain.

Here are 7 science-backed ways to lower it naturally:

1. Saunas (at 160-200°F)

[Myrrh @myrrh11117]

3 Bible verses so powerful that the enemy hopes you never discover them

[Bryan Johnson @bryan_johnson]

Some of us will live forever.

And if you’re reading this, that may or may not be you.

I am so bullish on this that I just renamed my company to Immortals.

Below:
+ why I think this
+ early signs of success
+ how to increase your odds

Yes, I know this sounds crazy.

Immortality has been an ambition for humanity since the beginning of recorded history.

The immortality I’m referring to is specific: increases in life expectancy will outpace the rate of aging. Meaning, we will no longer, by default, expect to die of natural causes.

I believe this for three reasons.

#1: Immortality already exists

Biology can reverse some features of aging, and in a handful of organisms escape it almost entirely. For example, a sperm and an egg from two people in their 30s carry the legacy of bodies that have aged for decades (the egg in particular has been arrested inside the mother since before she herself was born), yet they combine to produce an embryo that resets the aging clock to zero.

The immortal jellyfish goes further and resets itself within one lifetime, reverting its adult cells to an earlier stage through transdifferentiation and starting its life cycle again. And in the lab, scientists have begun doing this deliberately, making induced pluripotent stem cells (iPSCs) from mature adult cells such as skin fibroblasts, and using partial cellular reprogramming to turn the clock back in the tissues of living animals.

#2: AI offers new potentials

Biology is a hard problem. For most of history that complexity was beyond native human capacity. AI was made for this complexity. The clearest demonstration so far is protein folding. Predicting the three-dimensional shape a protein folds was an unsolved problem for roughly fifty years, and it mattered because a protein's shape determines what it does in the body.

DeepMind's AlphaFold2 effectively solved it in 2020, reaching a median accuracy of 92.4 out of 100, a level long thought to require the slow, painstaking work of crystallizing a protein and solving its structure by X-ray crystallography. It then released predicted structures for over 200 million proteins, nearly the entire catalogued protein universe, in a fraction of the time anyone expected.

#3: Early signs are encouraging

These aspirations are not imaginative. With the current tools in biotech Sid Sijbrandij, the co-founder of GitLab, was diagnosed with an aggressive bone cancer, osteosarcoma in his vertebrae. He treated his own disease like an engineering problem, he used AI to help direct several experimental, personalized therapies in parallel and drove the cancer into remission after standard medicine had given up. Around the same time, an Australian named Paul Conyngham, with no medical or biology background, did something similar for his dog. He used AI to help design a personalized mRNA vaccine targeting the specific mutations in his dog's tumor, and after it was given alongside another immunotherapy and within a few months the main tumor had shrunk by roughly three-quarters.

How to increase your odds…

I. Don’t die in the meantime

We don’t know when these longevity therapies will become available. Your goal is to be around when they come out. Buy yourself as much time as possible by looking after your body to the best of our scientific knowledge. Good diet, sleep, exercise will get you 80% of the results.

II. Find your achilles

Longevity therapies will likely be outcome specific. Individual specific drugs/therapies that target specific things like…

> prevent and remove arterial plaque
> prevent and reverse neurodegeneration
> specifically target and eliminate cancers, or pre cancerous legions
> prevent frailty and muscle loss, and regain muscle mass, strength and, bone density
> reverse skin aging
> rejuvenate eye health
> restore lost hearing
> etc

We don’t know what therapies will be available first. Your goal is to find what your body is struggling with most and keep that problem at-bay until a therapy is available that can fully cure or reverse it.

For example, do you struggle with cholesterol? Blood glucose control? Cognitive decline? Find your achilles heel and reduce your risk systematically.

III. Invest in the future

There are three macro trends happening on planet earth right now, and the people who bet on these areas have the highest risk + reward.

> AI
> Immortality
> Energy

As we know, power comes in many forms: money, social, political, health, etc. Those that can collect power in these fields will have the greatest chance of positioning themselves in the Immortal future.

With time, Immortal therapies will become broadly available.

If you’re reading this: don’t waste your chances by burning down your life points on a yolo-like mentality. Grind culture, addiction, social media pollution, fast food, porn, alcohol, these are all corporations turning your life into their profit. This is the Die Economy.

My company Immortals has the sole objective of turning your time, attention, and life into more healthy, functional, and prosperous minutes, days, and years. The Don’t Die Economy.

Good luck.

[Bryan Johnson @bryan_johnson]

what i'm eating for breakfast:

beet hummus, black lentils, arugula, eggplant, kalamata olives, asparagus, romanesco, artichoke hearts, hemp seeds, beech mushrooms, parsley, oregano, garlic, olive oil, marigold flowers as garnish, cannellini beans.

[y @ysuckme]

you gotta pray man… even on your best day

[Bryan Johnson @bryan_johnson]

I just launched a longevity Rx platform. Prescriptions I personally use are there.

v1 is live now.

Includes access to:

+ Tadalafil (Cialis)
+ Metformin
+ Oral Minoxidil
+ Tretinoin
+ Estradiol
+ Acarbose

We’re working with licensed doctors and pharmacies to make these medications accessible. Lots more in v2 coming next week.

[MDecker @m_dkit]

@Sokio8D I’m an african american living in the US. Where in EU can i afford to take drugs and do bodybuilding?