Madeline

@littleplainsxo 👾 Curating @madelinecurates 🎨 ex @IDEOVC @IDEO @ParsonsDesign @TheNewSchool

[Madeline @madsmacartney]

We partnered with @nvidia to host a demo night at @ideo! 16 startups presented, ranging from agentic AI networks, to US-made drones, and everything in between.

If you're an early stage startup focusing on emerging technologies DM me! We'd love to meet you at our next event.

[Madeline @madsmacartney]

@cynbahati directionally very good

[Chair (go to fivecamp) @_chair]

relatable

[Madeline @madsmacartney]

I bring a sort of unpredictable vibe to driving that Waymo’s don’t like

[Madeline @madsmacartney]

Maybe u should try heartmaxxing. empathymaxxing. listeningmaxxing. Weareallfromthesamemattermaxxing

[Emmett @emmettshine]

https://t.co/q4Y6sYaaT7

[Madeline @madsmacartney]

@patrickc @DanteLabs I did @NateraGenetics, which discovered a variant and subsequently led to a cancer diagnosis in my 20s.

[Madeline @madsmacartney]

@Alex_Cheru @zellersamuel Entirely at random. Decided to do @NateraGenetics after I learned that @23andMe has an incredibly high false negative rate

[Madeline @madsmacartney]

I was diagnosed with cancer in my 20s after sequencing my genome and discovering a variant. I probably wouldn't have been diagnosed for another 5 years if I hadn't followed this path. Understanding your DNA is everything (I am fine now :)

[Patrick Collison @patrickc]

I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools.

With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments.

Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know.

I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars.

(One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.)

There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!

[Madeline @madsmacartney]

@zellersamuel I'm so sorry to hear. If they were <40ish, there's a higher likelihood that a variant is at play. Although the caveat is not all variants are understood and there are many of "unknown significance". I still highly recommend the test! (I did @NateraGenetics)

[Madeline @madsmacartney]

@fastquant0 It was in their report! And a genetic counselor followed up. I used a lot of chatGPT to go over everything as well for more info

[Madeline @madsmacartney]

Did @NateraGenetics DNA sequence. Was notified in the report that a variant was discovered. Genetic counselor recommended increased screening.

A few weeks later, diagnosed w/ breast cancer at my 1st mammogram (in my 20s mind you). Immediately went into treatment at @StanfordMed

[fastquant0 @fastquant0]

@madsmacartney did it show up in the provider sequencer? or did you have to look it up yourself (using AI or search engine)

[Madeline @madsmacartney]

If you have a family member who has been diagnosed with cancer < age 40, that's an indication of a potential genetic link and you should definitely do a hereditary cancer screening (I did @NateraGenetics )

[Samuel Zeller @zellersamuel]

@madsmacartney Glad that you are ok!
What company did you used? I lost someone from my family to cancer so I think I’m gonna try sequencing

[Madeline @madsmacartney]

I did @NateraGenetics hereditary cancer screening and discovered a positive variant despite false negatives from @23andMe

[Ks @Ksaktweets]

@madsmacartney what test did you order? can you share your protocol?

[Madeline @madsmacartney]

Control center

[𓁹‿𓁹 @kitvolta]

the trick to surviving is having a european approach to life with somehow an american work output

[Rachel Karten @milkkarten]

cousin labs on the future of social media

[Madeline @madsmacartney]

lock in this summer!

[Willem @vanlancker]

Free Agency Season 3: Ideas matter.

An eight-week ideas residency in our New York office. Summer 2026.

Select, refine, and pressure-test a startup idea before you start the company. Applications now open.

[Madeline @madsmacartney]

I am anti credentials and anti logomaxxing. the biggest npc behavior is thinking you need to have the proper credentials to do something (right school, right vc investor, right city). High agency is just doing the damn thing regardless!

[Madeline @madsmacartney]

For generalists and creatives, the greatest value of AI is decreasing the time between idea and execution

[Emmett @emmettshine]

I’ve spent a lot of the past decade+ workingin DTC and eCom, and have seen the need for a shift toward an agentic-first model up close.

Excited to help launch Catalog, a team building the infrastructure layer that helps merchants’ products become intelligible, rankable, and discoverable by AI.

@littleplainsxo was responsible for brand strategy, identity, and launch website, built in a hybrid generative + human sprint. Big congrats Hamish & Dylan on the $3M raise. 🌿

Team Credits:
Caroline Bel-Kher - Lead Creative Product Manager
Setareh Rock - Project Manager
Madeline Macartney - Strategist
Rani Vestal - Brand Design
Sanghee Han - UI/UX Design
Gordon Cains - UI/UX Design
Sky Seo - AI Art Director
Fabrizzio Zampieri - Developer
Nicole Fernandez - Copy Director
Phillip McClure - Graphic Design
Ânia Gomes - Motion Design
Emmett Shine - Creative Director
Alex Leiphart - Digital Creative Director
Michelle Riis - Account Manager
Allie Epstein - Marketing Operations
Laura Romero - Operations
—
Hamish Gunasekara - CEO
Dylan Farrell - CTO