Mark Pownall

Sandler Fellow at @UCSF ( | PhD at @Yale @YaleGenetics | chromatin, transcription, microscopy, development 🐟🧬🔬

[Mark Pownall @MarkPownall5]

Our work describing Chromatin Expansion Microscopy is now out in @ScienceMagazine https://t.co/ysL8Q1xmqA Check out how we were able to visualize transcription, chromatin, and TFs with molecular resolution in developing zebrafish embryos to understand gene regulation!

[Elphege Nora Lab at UCSF @ElphegeNoraLab]

First preprint from the lab 🚨

How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process?

https://t.co/l7bwPsTSkd

(1)

[Yale Department of Genetics @YaleGenetics]

📣 Congrats to @GalJaschek, who was recently awarded a highly competitive PhD Fellowship from Boehringer Ingelheim Fonds. Gal is a @YaleGenetics graduate student in the @GiraldezLab. 👏 #TraineeTuesday [1/4]

[Mark Pownall @MarkPownall5]

@GalJaschek @YaleGenetics Congratulations Gal!! So excited for you!

[Marieke Oudelaar @MariekeOudelaar]

We have open @ERC_Research-funded post-doc positions to study #3Dgenome organization and #generegulation. We are looking for talented and motivated candidates, but prior experience in the field is not required. Please RT!

https://t.co/Mms2UwDVVP

[Mark Pownall @MarkPownall5]

@AshleyNAbel @NICHD_NIH @BernaSozen_ @YaleGenetics Yay! Congratulations Ashley!

[Mark Pownall @MarkPownall5]

Very excited to receive an honorable mention among this outstanding group of scientists for my PhD work with @GiraldezLab @YaleGenetics @Yale

[IMP @IMPvienna]

Breaking news! We're announcing the names of the six laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2023! 🏆
Congratulations to all awardees and honourable mentions! 🎉 1/
➡️ https://t.co/7gjnvpbpT8

[Mark Pownall @MarkPownall5]

HCR was a great tool to visualize miR-430 transcription with ChromExM in our recent paper!

[Molecular Instruments @HCRimaging]

This week’s #FluorescenceFriday user is Mark Pownall! #HCRimaging allows @MarkPownall5 to better understand how individual molecules of transcription factors are organized in the context of a specific gene. Check out his recent publication here: https://t.co/kyNp1yDPMw

[Mark Pownall @MarkPownall5]

@MiaoLiu_Yale Congratulations Miao! Beautiful work

[Aleksandra Galitsyna @agalitzina]

It took Sergey Ulyanov and I a while to shape fountains, a novel type of chromatin architecture. Here is our story of pioneering factors binding (@onichtchouk) and the loop extrusion (@leonidmirny) working together. (can you tell that I’ve been into fishkeeping since I was six?)

[Ashley N. Abel @AshleyNAbel]

Technologies to model early mammalian embryo development in vitro have advanced rapidly, providing new insights into self-organization and environmental control. @BernaSozen_ and I wrote a review as part of a special issue on #earlyembryonicmodels: https://t.co/F8o9WaxTcJ (1/3)

[Science Magazine @ScienceMagazine]

A new form of expansion microscopy called ChromExM can be used to expand chromatin to visualize transcription at high resolution, according to new research in Science.

Learn more ⬇️
📄: https://t.co/fIb7aFv4AJ
#SciencePerspective: https://t.co/K6HSlLl3Me

[Nature Biotechnology @NatureBiotech]

A modified protocol for expansion microscopy enables visualization of the spatial organization of chromating. #NBThighlight
https://t.co/iMPnbfUPmd

[Nikon Microscope Solutions @NikonInst]

Researchers apply #SuperResolution expansion #Microscopy #ExM towards imaging of chromatin in a developing embryo during zygotic genome activation, illuminating how Nanog interacts with nucleosomes and RNA polymerase II. Learn more: https://t.co/s6dxxUL2IT

[Yale Department of Genetics @YaleGenetics]

🔥 new paper led by @MarkPownall5 from the @GiraldezLab visualising chromatin, transcription, RNA Pol II and PF activity! 👇🏾👇🏼👇🏿👇

[Giraldez Lab @GiraldezLab]

🔬🧬 Excited to share our latest study https://t.co/kb3GfMrK32 @ScienceMagazine developing ChromExM which uses expansion microscopy to visualize the chromatin,
transcription, RNA POL II and pioneer factor Nanog during genome activation.

[Mark Pownall @MarkPownall5]

@AshleyNAbel @YaleGenetics Thanks Ashley!

[Mark Pownall @MarkPownall5]

@GalJashcek thanks Gal!

[Mark Pownall @MarkPownall5]

@DominicaCao thank you Dominica!

[Mark Pownall @MarkPownall5]

@FionaSievers Thanks Fiona!

[Science Magazine @ScienceMagazine]

This week in Science, a study reports “the most precise measurement yet” of the size of the electron’s permanent electric dipole moment.

The results have implications for an important unresolved question in physics—the imbalance of matter and antimatter. https://t.co/GyuCXRk6Zl