McCabe Lab

McCabe Lab @EPFL. This account is inactive. Find us on the web, Linkedin: or Bluesky:

[McCabe Lab @mccabelab]

Is the weakening of motor ability with age inevitable? In a new study, we find that increasing levels of the protein Trio in aging #Drosophila preserves motor synaptic structures, improves function and defers the age-dependent decline of motor ability https://t.co/FVpoE5OD5V

[Brian D. McCabe @briandmccabe]

Thank you to @TargetALS_fdn for supporting the #ALS research of the @mccabelab in the @Brainmind_EPFL @epflSV together with our collaborators Bernard Schneider and @liebscher_lab.

[EPFL Brain Mind Institute @Brainmind_EPFL]

The @mccabelab group in @brainmind_EPFL identify a protein that can delay the decline of motor ability during aging - https://t.co/44Qwe7ZVqj
@epflSV @EPFL_en @snf_ch

[McCabe Lab @mccabelab]

Delighted to contribute to the study of our Lausanne colleague @mc_gambetta , and co-authors, of long range meta-domains governing gene regulation in #Drosophila neurons - https://t.co/sIQZNHcAQK

[McCabe Lab @mccabelab]

Delighted to welcome the many visitors to our lab today to learn about motor ageing in #Drosophila as part of #PortesOuvertesEPFL. A special thanks to our hardworking presenters Evelyne & Greta and to all the supporting lab members.

[McCabe Lab @mccabelab]

Glad to have our submissions included and many congratulations to the outstanding winning images and videos.

[Swiss National Science Foundation @snsf_ch]

19 works received awards in the 2023 SNSF Scientific Image Competition: microorganisms, vortices, poverty, archives, a transparent frog... All of these images reveal hidden beauty in #Science.
#Photo #Video #Research #SwissScienceImage
https://t.co/TrfB6WAjRG

[EPFL Research Office @EPFL_ReO]

👏 Congratulations to #MSCA #EPFLglobalLeader fellow @rebcsmith on her recent publication!

[McCabe Lab @mccabelab]

Gratifying that we, with many others, could contribute to this important work https://t.co/gIbY1m0qUG and aid in modelling CerTra in #Drosophila. Hopefully this is the first rung on the ladder towards understanding and treating this novel neurodevelopmental disorder.

[Giovanni D'Angelo @Gio_Dangel0]

Sometimes working on basic science has implications for people’s life. Studying intracellular lipid trafficking we have stumbled upon a group of individuals affected by neurodevelopmental syndrome and bearing mutations in CERT1 https://t.co/LkTMMWYKWh

[Brian D. McCabe @briandmccabe]

Very honoured to be the new director of the BMI @Brainmind_EPFL & thank you all for your kind words of support. Neuroscience @EPFL_en cannot fail but to prosper with such tremendous colleagues. I eagerly anticipate the discoveries we will make together.

[Summer Research Program EPFL @SRP_EPFL]

Are you an #undergrad from anywhere in the world? Want to spend your next summer doing cutting-edge research in biology in Lausanne, Switzerland? Applications are now open for our renowned Summer Research Program in Life Sciences! @epflSV @EPFL_en
https://t.co/pvZiA2x1ao

[Brian D. McCabe @briandmccabe]

Thanks to @BPoD_mrc for selecting our scanning electron microscope images of #Drosophila eyes, generated by @JamshidAsadzade and Wei Jiao together with Graham Knott & EPFL BioEM https://t.co/fJeRvadhOM, as their image of the day. @mccabelab @Brainmind_EPFL @epflSV

[Biomedical Picture of the Day BPoD @BPoD_s]

Tangled Fly Eyes–Fruit fly model of aggregated #tau– protein implicated in #Alzheimer's–reveals affect on #nerve signalling. Image & research by @JamshidAsadzade et al @briandmccabe lab @Brainmind_EPFL in @NatureComms. Read more on https://t.co/xUu26iw8FE with @MRC_LMS & @rooph

[NeurosciencePhD_EPFL @EDNE_EPFL]

EDNE student Marine Van Campenhoudt appeared on @RTScqfd on @RadioTeleSuisse to talk about the recent publication of the @mccabelab on neurodegeneration led by @JamshidAsadzade - https://t.co/SoqBnSwThH: Listen to it here: https://t.co/VcfwrONupx

[McCabe Lab @mccabelab]

PhD student Marine Van Campenhoudt appeared on @RTScqfd on @RadioTeleSuisse today to talk about our recent work led by @JamshidAsadzade on neurodegeneration - https://t.co/yryh06DEAz. If you didn’t catch it live, you can listen to it here (en français) - https://t.co/HuekrMlwR8

[McCabe Lab @mccabelab]

Nice article about our work on Tau and Retromer - https://t.co/Agbq4zkSO7. You can also watch a visualisation of our new method to quantitate single axon neurodegeneration within #Drosophila brains here - https://t.co/dTFdyA2fok. @Brainmind_EPFL @epflSV @EPFL_Imaging

[EPFL @EPFL_en]

A new study by EPFL researchers reveals how a malfunctioning protein complex can lead to the buildup of toxic forms of Tau, a protein involved in Alzheimer’s disease and other neurodegenerative disorders.
https://t.co/hkAqqkLqz1

[NeuroLéman @NeuroLeman]

A new study by @mccabelab @Brainmind_EPFL reveals how a malfunctioning protein complex can lead to the buildup of toxic forms of Tau, a protein involved in Alzheimer’s disease and other neurodegenerative disorders. https://t.co/JK5Fv8WVhf #epfl

[EPFL Brain Mind Institute @Brainmind_EPFL]

New publication by @mccabelab in @NatureComms
Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau.
Congratulations to all the authors !
https://t.co/GGOKyE0p00 #epfl

[Brian D. McCabe @briandmccabe]

Delighted our Tau & Retromer study is published https://t.co/fJeRvacJZe led by the indefatigable @JamshidAsadzade. Grateful to our collaborators Graham Knott, Scott Small and @isantamaria & for the support of EPFL @LeBIOP, Bernard Schneider and the EPFL Gene Therapy platform.

[McCabe Lab @mccabelab]

The cruelest cut: new lab @NatComm paper https://t.co/Agbq4zkSO7 shows retromer deficiency (implicated in #PD & #Alz) increases human Tau truncation & toxicity. We develop tools to quantitate Tau neurodegeneration with single synapse/axon resolution in intact #Drosophila brains.