Alex Mendenhall

[UW Dept. of Laboratory Medicine and Pathology 🔬 @uwlabmedpath]

Join us for #Pathology Presents "Greatly increased lifespan by chemical tRNA synthetase inhibition via GCN4 / atf-5 / ATF-4 signaling" with Dr. McCormick on Wed, Dec 8 at 1:30pm PT.

Details: https://t.co/iIWsubEteM

#PathTwitter #MedEd

[Alex Mendenhall @mendenhall_lab]

https://t.co/WHpEpZlcON
@NatureComms @mkaeberlein @theNCI @PamLovesScience @uwlabmedpath @halo_uw @NathanShockCtrs
We just published our findings on introns controlling allele bias in @NatureComms
Many potential implications for aging and age-related diseases like cancer!

[Alex Mendenhall @mendenhall_lab]

@NatureComms @theNCI @uwlabmedpath
We urge our colleagues to please look at the evidence for a new role for introns in controlling allele bias/monoallelic expression and think how it might affect their own research or interpretations of existing data.
https://t.co/WHpEpZlcON

[Chelsea Parlett @ChelseaParlett]

n o r m a l

[Alex Mendenhall @mendenhall_lab]

https://t.co/WHpEpZlcON
@NatureComms @mkaeberlein @theNCI @PamLovesScience @uwlabmedpath @halo_uw @NathanShockCtrs
We just published our findings on introns controlling allele bias in @NatureComms
Many potential implications for aging and age-related diseases like cancer!

[Matt Kaeberlein @mkaeberlein]

Ground truth in biology: Your model is wrong. My model is wrong. Models are imperfect representations of reality based on what we think we know today. Our job as scientists is to figure out how they are wrong by experimentation and make them better as we get new data

[Sue Biggins @SueBiggins]

Celebrating #BSD40 @HutchBasicSci this week with a discovery from Adrian Ferre D'Amare's lab. They solved the structure of the TruB pseudouridine synthase bound to the RNA it modifies, work that suggested that RNA molecules need chaperones to fold.

[Matt Kaeberlein @mkaeberlein]

Fade to Black 2 from the WormBot F w/ @mendenhall_lab. Make sure your volume all the way up on this one!

[Alex Mendenhall @mendenhall_lab]

@mkaeberlein

[Alex Mendenhall @mendenhall_lab]

Fade to Black...
Aging is Different for Every Individual
Worms Dying in near Real-Time
Heterogeneity in Death Among Isogenic Animals
Fluorescent WormBot Development and Application Continues
@uwaging
@JasonNPitt1
@mkaeberlein
@NathanShockCtrs

[Alex Mendenhall @mendenhall_lab]

Happy Friday Fluorescent Protein Aficionados
Throwback Wormbow Pic
Let us know if you need any XFP vectors for worms!

[Alex Mendenhall @mendenhall_lab]

Here's the video of lysosomes at a seconds timescale. Look a the tubular lysosomes traveling between the circular lysosomes- pew pew - like little ray guns

[Alex Mendenhall @mendenhall_lab]

And here's a time lapse video of lysosomes for over 7 hours - you can see the accumulation of secondary lysosomes (red) - aging in realtime! And you can see the primary lysosomes filling with BFP like little blueberries! @mkaeberlein @uwlabmedpath #aging

[Alex Mendenhall @mendenhall_lab]

Lysosome networks get totally tubular with age (or stress):
Check out this little gif from an old worm's gut cell...
@mkaeberlein @WaskoBM #aging

[Matt Kaeberlein @mkaeberlein]

Used "prerelease" AGE Presents lectures in a grad course w/ @mendenhall_lab. One video/wk + a primary research paper. Students wrote individual "peer-reviews" for each paper, then met in small groups for collaborative review a la @eLife, then full class discussion. Was great!

[Alex Mendenhall @mendenhall_lab]

@NathanShockCtrs @UTHealthSA Thanks to the folks at the Barshop for the opportunity to present our work on stochastic autosomal allele bias and the implications for aging and age-related disease. Had a great time speaking with @KarlRodriguez and colleagues on April 21

[Alex Mendenhall @mendenhall_lab]

@senmorteco Thanks for the opportunity to speak with your group about differences in aging among genetically identical animals! Had a blast!

[Nathan Shock Centers @NathanShockCtrs]

Updated flyer & registration info for the Basic Biology of #Aging Spring Speaker Series w/ Rochelle Buffenstein, Su-In Lee @suinleelab, Veronica Galvan, Dario Riccardo Valenzano @dariovalenzano_ & Yuetiva (Deming) Robles @demingy. Register here: https://t.co/qUkOkLO3Ob @halo_uw

[Alex Mendenhall @mendenhall_lab]

@AndersonRozalyn Paper... online only journal...
... so far consensus seems to go with both...

[Alex Mendenhall @mendenhall_lab]

What do you find more compelling? An image or a scatter plot.... trying to convey that introns prevent stochastic allele silencing
@WaskoBM @PamLovesScience @benofreedman @BenLehner

[Alex Mendenhall @mendenhall_lab]

@KarlRodriguez @CollinEwald Let's do it!

[Alex Mendenhall @mendenhall_lab]

Check out Karl's results with extracellular matrix and lifespan - HSP-25::GFP on annuli I think - if I remember correctly - such a cool result... @CollinEwald @KarlRodriguez
I think the extracellular matrix is probably understudied in the context of aging...