Meng-meng Fu

AssistProf @berkeleyMCB Myelin, microtubules, Golgi outposts, RNA transport. Prev: PI @NIH, Barres Lab @Stanford, Holzbaur Lab @Penn, UG @Caltech. Personal acct

[Meng-meng Fu @Meng2Fu]

It was fantastic to work w. Ved & Rhiju! Ved was incredibly productive & received a R21 for this work.

This was a project that survived COVID, 2 lab moves, sabbatical...

We're fortunate & grateful to @ZucheroLab Brad for help w. oligo cultures after I left Stanford 🙏

8/8

[Meng-meng Fu @Meng2Fu]

Excited to share our new pre-print collab w. @RDasLab!

Study led by @VedTopkar brilliant MD/PhD student who used biochemistry and bioinformatics to probe the relationship between Mbp mRNA structure & transport/local translation in oligodendrocytes!

https://t.co/ZwgwC6UMBH

1/8

[Meng-meng Fu @Meng2Fu]

Combined w. work from Jackie Trotter & Doug Fields Labs, we propose a RNA switch model:

- During transport, hnRNP-F binds unstructured MLS to inhibit translation.

- At the cell periphery, membrane-bound Fyn kinase phosphorylates & releases hnRNP-F to initiate translation.

7/8

[Meng-meng Fu @Meng2Fu]

So this preprint opens up many new questions in astrocyte cell biology!

This was a real team effort:
- Postdoc Will Barclay started the project at the NIH
- Postbac Johanna Bergstrom and undergrad Eva Lopez analyzed data
- PhD student Lana Ho contributed imaging data

[Meng-meng Fu @Meng2Fu]

Excited to share our preprint on cytoskeletal organization in astrocytes!
https://t.co/u3DvsTTn5N

Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.

Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓

1/x

[Meng-meng Fu @Meng2Fu]

Many distal ends are enriched in GFAP.

We don't know what this means yet - maybe these can become endfeet that contact blood vessels. Astrocyte processes are heterogeneous in vivo (some contact blood vessels, others contact synapses) - like axons vs. dendrites in neurons.

7/x

[Meng-meng Fu @Meng2Fu]

@NogalesLab @IsabelLAllende @UIMP @irenevalmore Congrats Eva! I love Isabel Allende! Just finished reading Violeta 🥰

[Marisa Adhikusuma Jeffries @marisaajeffries]

You can support the next generation of myelin scientists by funding the Myelin Gordon Research Seminar: https://t.co/XtaQAwtQmq. @ubhjkri @MS_Focus @mssociety @NeuroForuMS @SfNtweets @GlialInitiative

[Meng-meng Fu @Meng2Fu]

Hard to quit this app because I need the cute animal videos!

Any colleagues in Scotland seeing this and want to invite me to give a talk? ☺️

[Journal of Cell Biology @JCellBiol]

🗓️ Mark your calendar! Join JCB special session at #CellBio2024 with an excellent panel of speakers: @s__ellis, @LabFriedman, @Meng2Fu, @BinyamMogessie, Andrew Muroyama, moderated by @oegemadesai_lab and @timisstuck!

See more info 👉 https://t.co/79Ceo3PAFd