Michael Grillo

The efflux of my soul is happiness.
Cardiovascular Disease specialist

[Afshine Emrani MD FACC @afshineemrani]

1/12
I'm a cardiologist.

"Should I take a statin?" is the question I get more than any other.

The honest answer depends almost entirely on one distinction most patients have never had explained to them — and getting it wrong in either direction costs lives or costs years of unnecessary medication.
Here's the complete framework. Save this and bring it to your doctor.

[DogeDesigner @cb_doge]

How to design your own agents with Grok?

Go to Settings -> Customize ->Create Agent

You can create multiple agents.

[Nebraskangooner @Nebraskangooner]

🚨 Here's my "longevity, anti-aging & wellness" routine for 2026

Been adding/removing things in 2025 and I finally got it to where I like it and willing to share. I'm not a doctor so DYOR and everyone's health and age is different but maybe you'll find things on here, research them, and find benefits.

Diet plays a big part as well. Use the "Yuka" app to scan foods for bad additives. The less ingredients in food the better. Use "Suppco" app to scan supplements for quality.

I'm sleeping better, my body fat is down multiple % and my sustained energy level all day is way higher. I can't even remember the last time I was sick. I don't need or even want to use caffeine anymore. Never used it much anyway. But I haven't used any caffeine product in quite a while and the last couple times I tried one I felt awful when I drank it, aside from a tea on occasion.

Just started using the dry sauna and so far I've really enjoyed that too.

Here's to improved health & wealth in 2026 🍻

[Ruben Hassid @rubenhassid]

How to set up Claude the right way:

(so you actually stop going back to ChatGPT)

→ more infographics at https://t.co/E3S5uvTDek.

[Hasan Toor @hasantoxr]

🚨BREAKING: Microsoft Research + Salesforce just dropped a paper that should scare every AI builder.

They tested 15 top LLMs GPT-4.1, Gemini 2.5 Pro, Claude 3.7 Sonnet, o3, DeepSeek R1, Llama 4 across 200,000+ simulated conversations.

Single-turn prompt: 90% performance.
Multi-turn conversation: 65% performance.

Same model. Same task. Just... talking normally.

The culprit isn't intelligence. Aptitude only dropped 15%.

Unreliability EXPLODED by 112%.

→ LLMs answer before you finish explaining (wrong assumptions get baked in permanently)
→ They fall in love with their first wrong answer and build on it
→ They forget the middle of your conversation entirely
→ Longer responses introduce more assumptions = more errors

Even reasoning models failed. o3 and DeepSeek R1 performed just as badly.
Extra thinking tokens did nothing.

Setting temperature to 0? Still broken.

The fix right now: give your AI everything upfront in one message instead of back-and-forth.

Every benchmark you've seen was tested on single-turn prompts in perfect lab conditions.

Real conversations break every model on the market and nobody's talking about it.

[Bull Theory @BullTheoryio]

🇺🇸 FED IS SIGNALING YEN INTERVENTION AGAIN JUST LIKE 1985. LAST TIME, THIS CRASHED THE DOLLAR BY NEARLY -50%.

In 1985, the U.S. dollar had become too strong. U.S. factories were losing business, exports were collapsing, and trade deficits were exploding. Congress was close to putting heavy tariffs on Japan and Europe.

So the U.S., Japan, Germany, France, and the U.K. met in New York at the Plaza Hotel and made a deal. They agreed to deliberately weaken the dollar. By directly selling dollars and buying other currencies together. That was the Plaza Accord and it worked.

Over the next 3 years:

- The dollar index fell almost 50%.
- USD/JPY moved from 260 to 120.
- The yen doubled in value.

This was one of the biggest currency resets in modern history. Because when governments coordinate in FX, markets don’t fight them. They follow. That decision changed everything.

A weaker dollar pushed:

- Gold higher
- Commodities higher
- Non-U.S. markets higher
- Asset prices higher in dollar terms

Now look at today.

The U.S. still runs large trade deficits. Currency imbalances are at the highest. Japan is again at the center of stress. And the yen is again extremely weak. That is why Plaza Accord 2.0 is even being discussed.

Last week, the NY Fed did rate checks on USD/JPY, which is the exact step taken before FX intervention. It signals willingness to sell dollars and buy yen, just like 1985.

No intervention happened yet. But markets moved anyway. Because they remember what Plaza means.

If that starts again, every asset priced in dollars will skyrocket.

[Camus @newstart_2024]

Dr. Pradip Jamnadas breaks it down simply for beginners: Glucose (sugar) in the bloodstream is toxic—it glycates everything (vessels, enzymes, hormones), aging you prematurely.

Body's fix? Pancreas pumps insulin to shove glucose into cells (liver, muscle, everywhere). Eat carbs/starch every 2–3 hours? Insulin spikes repeatedly, never fully drops—leading to chronic high insulin (hyperinsulinemia).

Result over years:
- Insulin resistance (body needs more insulin for same effect)

- Fatty liver & dangerous visceral belly fat (glucose → new fat around organs)

- Silent metabolic destruction long before diabetes shows up (A1C normal, but damage underway)

By diagnosis of diabetes? Often 10+ years of hidden high insulin + early coronary disease.

This 6:05 clip is the clearest "insulin-glucose 101" I've seen—why constant grazing wrecks metabolism.

Do you eat every few hours (snacks/meals)? Noticed belly fat creep despite "normal" weight?
Tried reducing frequency (e.g., 2–3 meals/day) to lower insulin—any energy/weight shifts?
What's one carb habit you're rethinking after this?

Real experiences only—let's unpack how this shows up in life.

[Nicholas Fabiano, MD @NTFabiano]

Higher creatine intake is associated with a lower risk of cancer.

[Mindset Machine  @mindsetmachine]

This short video will make you rethink your entire life…

[Chris Burniske @cburniske]

I'm not a buyer yet, but if I were to be a buyer, imo the areas to watch for $BTC are:

~$80K: Nov '25 low, local low of this "bear"
~$74K: April '25 low, Tariff Tantrum low, just below $MSTR's cost basis (~$76K)
~$70K: Top of $50-70K range, near '21 high
~$58K: 200W SMA & on-chain cost basis (RV = ~$56K)
~$50K & below: bottom of the weekly range below, psychological, below this number you would see "death of BTC" calls once again

Importantly, I don't care what happens. If we rally from here, I'll ride what I have and diversify my portfolio, if we fall apart I'll buy more $BTC & select cryptoassets.

[High Performance Founder @hpfounder]

The best gift you could ever give your family is getting your body in shape.

[MERICA MEMED @Mericamemed]

100X better than Beyonce covering Jolene

[👺 Silas B. 👺 @SilasUnleashed]

This is exactly why we have our 2nd Amendment.

[Michael Grillo @mgrillod]

@TheCinesthetic @grok what movie is this?

[Dr Paddy Barrett @Paddy_Barrett]

A high V02 Max is the metric most closely linked to a longer life.

But what is V02 Max?

And more importantly, how do you increase it?

Because most people are doing it wrong.

📕Make Sure To Bookmark✅

🧵👇

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[Next Up with Mark Halperin @NextUpHalperin]

"It's not that hard. Be honest. Say what happened. Say what we all saw..."

@MarkHalperin calls out Jake Tapper's "weak tea" in claiming he covered Biden's cognitive decline before his book.

Watch and download:
https://t.co/TTQ5RXFdXV

https://t.co/H3ijCS4RsP

[Next Up with Mark Halperin @NextUpHalperin]

.@MarkHalperin: "You've got at CNN this guy Brian Stelter, who's their media reporter, who's an ally of Jake Tapper, to protect Jake Tapper's image... It's nothing short of journalistic corruption, and it's missing the moment..."

Watch and download:
https://t.co/r9TLzXCunB

[Curtis Houck @CurtisHouck]

CNN’s @ScottJenningsKY on tariffs: “This is new DNA for the Republican Party. That's why you hear Republicans and business guys who’ve basically been Republicans struggling with what to do because the DNA of the party, for as long as any of us have been around, has been tariffs are bad, taxes should be low, free markets, etc., etc....Here's the flip side...Trump shows up with different advisers and different thoughts about asking questions. How well have we done if you're a working class, you know, person and you've seen your job shipped overseas and you don't have the same kind of opportunities that perhaps you thought you were going to see. How well have certain segments of our society done? Is wealth inequality, you know, because of some of these, you know, trade ideas over the years that have just seen jobs go away from people who previously could get jobs and live a comfortable, middle class lifestyle, so accepting this new DNA is going to be hard for some. You mentioned, Rand Paul and Ted. Cruz and others. You know, they've been out there. Some are reluctantly accepting it, like John Kennedy. Others are running with it hard. How the party continues to accept that will probably be closely related to whether or not it works, you know, over the six to nine months. That's why I thought Kennedy was being honest. If it works, it’ll be great and if it doesn't, we'll recalibrate...Where I come from, there is wealth inequality.”

[Sadie @Sadie_NC]

This is the man the left are trying to vilify and tell you he is stealing your money.