Maciej Meglicki

[Magdalena Zernicka-Goetz @ZernickaGoetz]

I just spotted this post and it is nearly 5 years later and the new answers brought new questions to track … if your interested in early development and symmetry breaking and self-organization, please get in touch with us, ideally by email as our lab don’t check X regularly

[The Boroviak Lab @boroviak_lab]

Amazing opportunity to learn more about embryogenesis, the placenta and fetal growth!

Spread the word and we are looking forward to seeing you in Cambridge this July!

[The Boroviak Lab @boroviak_lab]

Curious embryo fact 9/25

Primordial germ cells (PGCs) give rise to eggs in females and sperm in males.

In the 4th week, primordial germ cells leave the embryo!

They migrate into the yolk sac.

Thus, the next generation – the precursors to the offspring of the developing embryo - temporarily reside outside of the embryo!

It is unclear why.

One hypothesis is that primordial germ cells undergo this migration to escape differentiation-inducing signals inside the embryo.

#devbio #embryo #reproduction

[Prof. Nikolai Slavov @slavov_n]

Timescales in Cell Biology

[Schuh Lab @SchuhLab]

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired?

Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥

https://t.co/hd8iT1TKnJ (1/13)

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[Maciej Meglicki @mmeglicki]

@AdiyantL @MZG_Lab Finally! Congratulations once again!

[Bailey Weatherbee @BailWeatherbee]

After reporting our embryoid model last year, @_carlosgantner_ and I wanted to put a protocol together.

Out today in @NatureProtocols:
https://t.co/zNtAM7S8fN

Big thanks to Carlos for spearheading, Yuntao Wang for the help, and @ZernickaGoetz/@MZG_Lab for supervising!

[Magdalena Zernicka-Goetz @ZernickaGoetz]

I’ve been presenting our human stem cell embryo model, derived from programmed human ESCs, at conferences for a few years and last year, we finally published it. Now we’re excited to share a detailed protocol how to create these models #StemCellResearch

https://t.co/JqipYyEQco

[Nature Methods @naturemethods]

It's that time of year!! 🎉We are so excited to announce our 2023 pick for Nature Methods' Method of the Year: methods for modeling development. Read the Editorial to find out why we chose this as our pick. #moty2023

https://t.co/RNLeOZLE52

[Maciej Meglicki @mmeglicki]

I'm very excited to share our latest preprint!

[Maciej Meglicki @mmeglicki]

@LIwamotoStohl @MZG_Lab @slavovLab Congratulation Lisa @LIwamotoStohl!
It's been real adventure to be part of this exciting project!

[Adiyant Lamba @AdiyantL]

Excited to share our preprint! We delve into the ways that a mouse embryo breaks symmetry and specifies cell fates for the first time. It turns out that cells polarize asynchronously at the 8-cell stage, and this has implications for lineage allocation:
https://t.co/jHtbnulr87

[Maciej Meglicki @mmeglicki]

@AdiyantL Congratulations @AdiyantL. It was wonderful to see you developing this project focusing on important questions re the link between early heterogeneity, polarization and cell fate. Working with you,@zhumeng123 and everyone involved in this work was a great experience and real fun!

[The Scientist @TheScientistLLC]

“I was taken by the beauty of the complexity,” @ZernickaGoetz said about the embryos she’s studied for almost three decades.

Read about her research and leadership in this Peer Profile: https://t.co/1f3knh3GQx

[Schuh Lab @SchuhLab]

Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for that long?

Our latest research in @NatureCellBio reveals that oocyte maintenance involves exceptional protein longevity. https://t.co/ZiByc9F4hS (1/9)

[Stem Cell Podcast @stemcellpodcast]

The @MZG_Lab is back at it again with a new @CellCellPress paper!

They used lineage tracing to show that the majority of the #epiblast is derived from only one 2-cell stage blastomere.

@JunyentSergi @mmeglicki

🔖 https://t.co/GdFRgTWnU4
🎧 https://t.co/dL7CAhoLmm

[Maciej Meglicki @mmeglicki]

I'm very excited to share another paper from our @MZG_Lab ! Great work by amazing Meng Zhu (@zhumeng123) and everyone else participating!
I'm proud I could contribute to this work as well :)

[Meng Zhu @zhumeng123]

Excited to share our new work!!🥳How do cells lose totipotency to fate segregation? w @MZG_Lab we found that early blastomeres experience a "Composite State" by displaying dual-lineages signatures! Link for full text👉: https://t.co/n10KchKhda

[Maciej Meglicki @mmeglicki]

@zhumeng123 @AdiyantL @PeizheW @kcowardoxford @LSE_Angela @ZernickaGoetz It was a privilege to contribute to this project!! You are the best!!!

[Maciej Meglicki @mmeglicki]

@ZernickaGoetz @MZG_Lab As always, it was great to visit Caltech and spend time time together on experimental work and fruitful discussions about our projects and labs!