Mahmood Panjwani

Co-founder, iManage (Nasdaq: IMAN). Now building at the cellular edge of longevity & human performance. VO₂max, mitochondria, healthspan.

[Ray Dalio @RayDalio]

Put your insecurities away and get on with achieving your goals. Reflect and remind yourself that an accurate criticism is the most valuable feedback you can receive.

Imagine how silly and unproductive it would be to respond to your ski instructor as if he were blaming you when he told you that you fell because you didn't shift your weight properly. It's no different if a supervisor points out a flaw in your work process.

Fix it and move on. #principleoftheday

[Danyal @danyal_xyz]

You should only start a company if it’s foundational insight is the hill you’re willing to die on

[Mahmood Panjwani @mmpanjwani]

Agents will work for the company or for you. Facebook has spent twenty years showing which one it picks: Cambridge Analytica, a $5B FTC fine, teen harm research it buried. Zuck treats users as inventory. Want to hand him your private data so he can profit off you?

[Vinod Khosla @vkhosla]

Agents will either be the corporate's agent with the consumer as the "product" they sell (as Muse will be) or be the consumer's agent (as in Fo) truly looking out for the consumer's interest.

https://t.co/EEQZYeu0aV

[Vinod Khosla @vkhosla]

Agents will either be the corporate's agent with the consumer as the "product" they sell (as Muse will be) or be the consumer's agent (as in Fo) truly looking out for the consumer's interest.

https://t.co/EEQZYeu0aV

[Mahmood Panjwani @mmpanjwani]

@shivon You are a class act. You gave it everything. Godspeed

[Ray Dalio @RayDalio]

Loyalty to specific people who are not in tight sync with the mission and how to achieve it will create factionalism and undermine the well-being of the community. It is often the case, and quite beautiful, that personal loyalties exist. However, it is also often the case, and quite ugly, when personal loyalties come into conflict with the organization's interests. #principleoftheday

[Mahmood Panjwani @mmpanjwani]

@chamath Marginal cost near zero.
Labs get acquired?
Trillion dollar valuations, poof.
Infrastructure is where it’s at.
Alphabet, Amazon, Microsoft, Meta, SpaceX, Tesla, Netflix …

And consumer staples? Real Eatste?
Higher gross margins for them?

[Ray Dalio @RayDalio]

Smart people are the ones who ask the most thoughtful questions, as opposed to thinking they have all the answers. Great questions are a much better indicator of future success than great answers. #principleoftheday

[Mahmood Panjwani @mmpanjwani]

@RayDalio Agree wholeheartedly. May I offer a third leg, especially for the young: a deliberate focus on healthspan. Meaningful work and meaningful relationships both compound on it. Most of us start too late.

[Mahmood Panjwani @mmpanjwani]

@BillAckman Great to see VO2max testing treated as table stakes. Curious whether Vosk does anything at the mitochondrial level, like intermittent hypoxic-hyperoxic training (IHHT). That’s the upstream lever that actually raises VO2max. That is the next frontier.

[Mahmood Panjwani @mmpanjwani]

@RayDalio Ray,
In a world of dizzying chaos and change, you are a voice of reason and clarity, a steady signal of Order in the noise. Appreciate your “service” to humanity.

[Ray Dalio @RayDalio]

Watch out for people who argue against something whenever they can find something--anything-- wrong with it, without properly weighing all the pluses and minuses. Such people tend to be poor decision makers. #principleoftheday

[Mahmood Panjwani @mmpanjwani]

#NewProfilePic

[Dr. Rhonda Patrick @foundmyfitness]

If you want to meaningfully impact aging in America, start with obesity—few things erode longevity and quality of life as profoundly, accelerating the biological aging process and fueling nearly every major chronic disease.

Obesity alone is linked to 13 types of cancer and cuts life expectancy by 3–10 years, depending on severity. It promotes DNA damage and accelerates our fundamental aging process—often measured by epigenetic age. It’s one of the principal differences between the U.S. and many of the world’s longest-lived nations.

We’re overfed but undernourished. 60% of all calories Americans consume come from ultra-processed foods that:

• Fail to induce proper satiety, pushing us to overeat.
• Remain cheaper than whole foods, economically incentivizing the least healthy choices.
• Hijack our dopamine reward pathways, reinforcing addictive eating behaviors.

This trifecta—no satiety, low cost, and built-in addictiveness—keeps us in a cycle of poor health outcomes and runaway healthcare costs.

But caloric excess is only part of the problem—we are also nutrient-deficient.

Low omega-3 levels—affecting 80 to 90% of Americans—carry the same mortality risk as smoking. Vitamin D deficiency—easily corrected—compromises immune function, cognition, and longevity. Nearly half of Americans don't get enough magnesium—impairing DNA repair and increasing the risk of cancer.

We are not solving these problems—we are medicating them. The average American over 65 takes five or more prescription drugs daily—stacking interactions that compound in unpredictable ways.

We must start treating physical inactivity as a disease. It carries the same mortality risk as smoking, heart disease, and diabetes. Going from a low cardiorespiratory fitness to a low normal adds 2.1 years to life expectancy.

By age 50, many Americans have already lost 10% of their peak muscle mass. By 70, many have lost up to 40%.

This isn’t just about looking strong. It’s about survival.

• Higher muscle mass means improved insulin sensitivity - it means a 30% lower mortality risk.
• Grip strength is a stronger predictor of cardiovascular mortality - the number one cause of death in the United States - than high blood pressure.
• The strongest middle-aged adults have a 42% lower dementia risk.

And yet, we treat resistance training as optional. It is not. It is the most powerful intervention we have against aging including increasing muscle mass, strength and bone density.

Hip fractures alone kill 20–60% of older adults within a year. This is a death sentence we can prevent with resistance training - which has been shown to lower fracture risk by 30-40%.

The current RDA for protein is too low for older adults.

Studies have shown when it's increased by half this reduces frailty by 32%, while doubling it, combined with resistance training, increases muscle mass by 27% and strength by 10% more than training alone. If we want to prevent muscle loss and frailty, we must update our protein recommendations and prioritize strength training.

We must foster a culture of American exceptionalism built on daily, effortful exercise. Not as an afterthought. Not as a luxury. But as a non-negotiable foundation for aging, but also clear thinking, resilience, and even leadership.

The body and brain are not separate. The consequences of poorly regulated blood sugar, sedentary living, and muscle loss are not just physical—they affect cognition, judgment, and resilience.

We cannot medicate our way out of what we have behaved our way into.

Grateful for the chance to share my voice at the Senate Aging Committee (@SenateAging). A special thank you to Senator Rick Scott (@SenRickScott) for making this opportunity possible.

[Mahmood Panjwani @mmpanjwani]

@prof_horvath Looking forward to being there!

[Mahmood Panjwani @mmpanjwani]

@Altimor As a Silicon Valley veteran deep in the product market fit, the velocity of creativity for remote people is a fraction that of in-person team mates. We tried remote last year. The data was overwhelming. We now have turned down the most qualified people who cannot be in person

[David Sinclair @davidasinclair]

Great thread. Also, bowhead whales’ efficient DNA break repair explains why they live so long - they presumably have a hyper-stable epigenome

[Mahmood Panjwani @mmpanjwani]

@philosophising4 thank you for your posts Miss Mito. Learning a ton.

[President Biden Archived @POTUS46Archive]

You shouldn’t have to pay an extra $50 to sit next to your child on the plane, pay a surprise “resort fee” for a hotel stay, pay $200 to terminate your cable plan, or pay huge service fees to buy concert tickets.

It’s time for Congress to pass the Junk Fee Prevention Act.

[President Biden Archived @POTUS46Archive]

Just a few finishing touches! Hope you and your loved ones are having a great Christmas Eve.