Felipe Morillo, PhD 👨‍🔬🦠🏳️‍🌈

A guy who loves the wonders of microbiomes

[Felipe Morillo, PhD 👨‍🔬🦠🏳️‍🌈 @morillo_fe]

1/12 🧵 My PhD thesis is out! “Host genetics shapes crypt/mucus niche colonisation by keystone gut bacteria, influencing metabolic health” (https://t.co/hYn4AViNJS). Let’s go through the main points 😉

[Ｊｕｎ Ｙａｓｕｄａ @jyasuda1]

マウスの実験で老化した腸内細菌巣が迷走神経系を介して脳に作用し、認知機能を低下させるという研究。原因菌や、関連する細胞内経路も確認。Nature。

https://t.co/ted0TNB24t

[Cell Host & Microbe @cellhostmicrobe]

How to measure microbiome health?

Commentary proposes adaptive coherence: capacity of host-microbiome systems to sustain integrated function via reorganization. Reframes health as emergent & relational, w/measurements of adaptability/functional integrity
https://t.co/f5CA0KYbwx

[Cell Host & Microbe @cellhostmicrobe]

Microbes as architects of colonic patterning

Highlight of @CellCellPress paper discovering regionalization of colonic epithelium depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium.
https://t.co/AX4sPHgVw0

[Dr Graham Lloyd-Jones @DrGrahamLJ]

Fascinating oral and gut microbiome study which concludes …

‘… several diseases and conditions that are currently considered non-communicable should be re-evaluated’

👇👇👇
Valles-Colomer et al 2023
https://t.co/oHYgEeB9L1

[Trends in Microbiology @TrendsMicrobiol]

Micro-scale spatial metagenomics opens a new era in microbiome ecology https://t.co/cFBkw1Tz9M

[Shomron Ben-Horin @ShomronH]

Interstingvfindings showing how intricate intetplay between bacteria and host's differring local tryptophan pathway IDO1 enzyme upregulation may explain region-restriction of Crohn disease

[GutMicrobiota Health @GMFHx]

What happens in the gut doesn't stay in the gut

@ChristophThaiss et al. identified a pathway linking microbial and metabolic changes over the lifespan, peripheral inflammation, vagus nerve dysfunction, and reduced memory formation:

https://t.co/kMtlyC4Jwu

[Gut Microbiota for Health NW @GutMicrobiotaWW]

#Probiotics are commonly used to prevent an altered #gutmicrobiome after taking antibiotics

But why are probiotics alone insufficient for sustained gut microbiota modulation?

@WorldGastroOrg

https://t.co/OBXsYbVJjS

[Nicholas Fabiano, MD @NTFabiano]

Gut bacteria was transferred from depressed humans to rats.

The rats developed features of depression.

[Shining Science @ShiningScience]

Scientists linked chronic fatigue to a deficiency in butyrate-producing bacteria.

Recent breakthroughs published in Cell Host & Microbe and Nature Medicine have uncovered a profound connection between the gut microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers from Columbia University and the Jackson Laboratory found that patients suffering from this debilitating condition often lack specific health-promoting bacteria, most notably Faecalibacterium prausnitzii. This deficiency leads to a critical shortage of butyrate, a short-chain fatty acid essential for maintaining the gut barrier and regulating energy metabolism. Without these vital microbial components, the body enters what experts describe as a "gut-driven energy crisis," directly impacting a patient's physical and mental stamina.

The implications of these findings are transformative for the millions of people living with chronic fatigue. The studies demonstrated that the reduction of beneficial microbial species like Roseburia and Coprococcus is directly correlated with the severity of a patient's symptoms. By pinpointing these specific biological markers, scientists are now closer than ever to developing precise diagnostic tools and therapeutic interventions that target the microbiome. Rather than treating fatigue as a vague symptom, medical professionals can now look toward restorative gut treatments as a viable path to reclaiming energy and health.

source: Cell Host & Microbe and Nature Medicine (2025). Microbial Alterations and the Gut-Driven Energy Crisis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

[Science Advances @ScienceAdvances]

According to a new study, wheat fiber-enriched foods may reduce gut inflammation and curb the development of inflammatory bowel disease. https://t.co/rtDpixZzFo

[GutMicrobiota Health @GMFHx]

Is it time to explore the brain microbiome?

Recent findings in @PLOSBiology observed translocation of bacteria from the gut to the brain via the vagus nerve in mice:

https://t.co/YkCsGMJNIa

[Microbes.info @MicrobesInfo]

Engineered #biochar and beneficial #bacteria team up to boost #crop growth ...

| #agriculture | #MicroSky | #sewage | #sludge | #nitrogen | #carbon | Via eurekalert .org

https://t.co/jcQDQlN9Wl

[Huiluo Cao 曹慧荦 @hlcao]

Generalist biological artificial intelligence in modeling the language of life | Nature Biotechnology https://t.co/qyqX3HYGD8

[Biton Lab @bitonslab]

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens.
https://t.co/j9lKSXVI35

[Vivek Mutalik @vivek_mutalik]

Excited to share this review🔔, we spent sometime thinking about
phage–microbiome–immune–oncology axis for phage therapy in cancer!
#phage
Phage therapy in oncology: opportunities for cancer prevention and treatment: Trends in Molecular Medicine https://t.co/rxn8RCCU1p

[Tominaga K. (tomiken) @pacyc1841]

Microbiome Datahub: an open-access platform integrating environmental metadata, taxonomy, and functional annotation for comprehensive metagenome-assembled genome datasets | Microbiome | Springer Nature Link https://t.co/TEbv6JfExG

[Cameron Thrash @jcamthrash]

Environmental quality affects the formation of generalist and specialist taxa in microbial communities https://t.co/KZ4PjxSS2C

[GutMicrobiota Health @GMFHx]

Gut health is everywhere, but what does it mean, how can it be measured, and what are its implications for health?

This new @ISAPPscience-led review article in @NatRevGastroHep updates what every healthcare professional needs to know:

https://t.co/H9FjpwelGR

[Cell Host & Microbe @cellhostmicrobe]

Gut phage ACRs

Type II CRISPR-Cas systems dominate human gut w/diverse phage Acrs targeting these systems. Widespread family, GutAcraca, adopts similar structures to inhibit Cas9 & regulate its own expression, highlighting phage adaptation to gut ecology
https://t.co/LM4ke5mLAY