Matthew Traylor

Specialist (Genetics) at Novo Nordisk Research Centre Oxford

[Matthew Traylor @mtraylor_]

@rainermpg @Nature Congrats Rainer and @AniketMishra87 👏. Great work!

[Chris Whelan @chrisdwhelan]

Our pre-print describing the @uk_biobank Pharma Proteomics Project (UKB-PPP) is now online!

https://t.co/ymJuXDw9sg

We identify 10k+ genetic associations w/ protein concentrations; 85% are new.

The data should help drive discovery of new biomarkers, diagnostics & medicines.

[Joanna Howson @joannahowson]

I am looking for an in silico human #genetics scientist to join us at #Novonordisk research centre Oxford. If you are excited to bring your expertise to advance drug discovery in cardio metabolic disease, come join our fantastic team: https://t.co/zhD08RE1Wv

[Brain @Brain1878]

In a genome-wide study of DTI metrics, Traylor et al. reveal an association between white matter microstructural integrity and a common structural haplotype variant of complement component 4 called C4-BS. https://t.co/j1eMqg0D9o

[Tom Richardson @iTomRichardson]

Exciting job opportunity to join our team working at the Genetics Department @novonordisk using human genetics to help identify and validate drug targets 🧐https://t.co/ASEeOzxSpc - please get in touch with @joannahowson with any questions

[British Heart Foundation @TheBHF]

Scientists have identified new genetic clues in people who’ve had ‘silent’ strokes that are difficult to treat and a major cause of vascular dementia https://t.co/NyBxUuXPwN

[Matthew Traylor @mtraylor_]

@CDAndersonMD Cheers Chris, always a pleasure to work with you

[The Lancet Neurology @TheLancetNeuro]

ONLINE FIRST: Matthew Traylor and colleagues report the results of their GWAS to identify novel associations and provide mechanistic insights into lacunar stroke
https://t.co/UUhV0tg0Xx
@mtraylor_ @CamStroke

[Cambridge Stroke @CamStroke]

Our GWAS on lacunar stroke just out. Finally beginning to unravel genetics of this important disease with 12 loci. Collaboration of many in ⁦@StrokeGenetics⁩ funded by ⁦@TheBHF⁩ ⁦@CamNeuro⁩ ⁦@Cambridgecardio⁩ ⁦@mtraylor_⁩ https://t.co/MvZW5RDlEb

[Matthew Traylor @mtraylor_]

@Don_lyall Weird one. What is actually going on here? prodromal dementia?

[Matthew Traylor @mtraylor_]

@MarkKevinBakker @StrokeGenetics @NatureGenet Great work Mark!

[Mark K. Bakker @bakker_mk]

It is out! Genome-Wide Association study of intracranial aneurysms.
My first first-author paper, happy!! 😃🤓
More info will follow, but let me first do a *major shoutout to all collaborators* especially the ISGC @StrokeGenetics
@NatureGenet
https://t.co/wfDj5AaKtp

[Matthew Traylor @mtraylor_]

Major kudos to reviewer 2 who put in a winking smiley face and ended with 'good luck'. Why can't every reviewer be like that?

[Nature Communications @NatureComms]

Genetic data from large cohorts of unrelated individuals can help predict individual risk of developing specific diseases. @buutrg et al. show that smaller cohorts of related individuals can be a similarly powerful tool: https://t.co/TwwYULcle0
@DrXuanZhou
@ThucDuyLe
@honglee0707

[David Howard @Used_For_Glue]

New research looks at the relationships between genetic risk for #depression and various traits & the brain using @uk_biobank

For me, the most interesting finding is the causal effect of genetic risk for depression on white matter microstructure ☹️➡️🧠

https://t.co/JlCtc0t3is

[Nature Communications @NatureComms]

Persyn et al. perform genome-wide association studies for magnetic resonance imaging markers of cerebral small vessel disease , explore genetic correlations, and prioritise candidate genes:
https://t.co/BJ491qoOPG

@cathrynlewis; @mtraylor_; @PersynElodie

[Dr Cathryn Lewis @cathrynlewis]

Out today in @NatureComms, our new paper from Elodie Persyn, @joannahowson @mtraylor_, Hugh Markus, @CamStroke, which looks at MRI markers of cerebral small vessel disease in @uk_biobank participants.
https://t.co/dqF4qf1dR6
Short version of what we did/found (1/8)

[Mika Kivimaki @MikaKivimaki]

Excellent review on diabetes complications.
Covers classic microvascular disorders and cardiovascular disease but also effects on cognition and mood.
https://t.co/yp0JHq4hzt

[Matthew Traylor @mtraylor_]

Interesting paper showing high frequency of NOTCH3 cysteine changing mutations in the Taiwanese population, particularly in patients with cerebral small vessel disease

[Nat Rev Neurology @NatRevNeurol]

A NOTCH3 cysteine-altering variant is an important risk factor for stroke in the Taiwanese population https://t.co/d4SYdh7a2h