ne digga (bio/acc)

longevity. immunology. mathematics. technology. political innovation. cryptocurrency.

[ne digga (bio/acc) @nedigga3]

@ayogiovanna engulfment-abandonment dyade

[David Pearce @webmasterdave]

@nedigga3 @Dr_Singularity Yes. I’m fairly confident it will happen. Painfree life will be as taken-for-granted as painfree surgery. But as you say, immense unnecessary suffering will be undergone until the transition occurs.
We need an abolitionist Bryan Johnson.

[ne digga (bio/acc) @nedigga3]

@webmasterdave @Dr_Singularity at some point there will be a bryan johnson moment for abolitionism

the question is do we get there in time before blowing ourselves up and if so, how much unnecessary suffering do we have to endure on the way there?

[ne digga (bio/acc) @nedigga3]

@celestialbe1ng it also works systemically that way, by reducing lactate production and mosquitoes are usually attracted to lactate in sweat

[ne digga (bio/acc) @nedigga3]

nicotine actually upregulates nACh receptors with long-term administration

https://t.co/N2Ja11KhLu

smoking is also much more damaging to vascular health than isolated nicotine in pouches, although both lead to some vasoconstriction

[Dr. Ben Braddock @GraduatedBen]

I think heavy use of nicotine pouches is going to end up being worse for brain health than even pack-a-day smoking, via acetylcholine receptor downregulation, and chronic vasoconstriction leading to endothelial dysfunction > reduction in white and gray matter.

[ne digga (bio/acc) @nedigga3]

@luluneverstops @marclou his RHR is still excellent even after a 10% drop

so I don't think this shows fragility at all

[ne digga (bio/acc) @nedigga3]

@avidseries or the earlier you are born, the happier you are

we will see how GenZ happiness evolves when they get older

[ne digga (bio/acc) @nedigga3]

@bryan_johnson are you taking oral isotretinoin?

because this is a very common side effect

[ne digga (bio/acc) @nedigga3]

you are obviously right, because any gene or combination of genes must be expressed in a certain manner before exerting any effect, so epigenetics will mediate most "genetic effects"

also for some reason genetic determinists do not seem to understand that studies show INTERINDIVIDUAL VARIANCE is primarily determined by GENETIC VARIANCE, which one would expect given the homogenous environments we have today (e.g. schooling, culture etc.)

the more similar our environments, the more any trait will look "genetically predicted"

[ne digga (bio/acc) @nedigga3]

@SteveStuWill a few months could plausibly be enough to sample faces in a way that shapes subjective aesthetic judgement

so not sure this proves inheritance, could also just be faces are intensely sampled for a few months after birth and shape aesthetic judgements

[John Carter @martianwyrdlord]

Many say that we should skip terraforming and jump straight to disassembling the planetary bodies for raw material with which to construct a Dyson swarm of solar power collectors and O'Neill cylinders.

I do not like this idea. It would do great and irreversible spiritual damage to mankind to destroy the wandering gods that have populated our skies since long before the species was born. The justification for such a settlement strategy - maximum solar energy, maximum inhabitable surface area - is indistinguishable from the minmaxing mindset that has led us to convert our civilization's material culture to a homogeneous sprawling blob of McMansion subdivisions, condo towers, strip malls, distribution warehouses, parking lots, freeways, industrial monocrops, factory farms... The thought that we might continue this pattern in space on a vastly larger scale, turning the solar system into the cosmic equivalent of a Bangladeshi tenement crowded with eighteen gorillion hominoids living under Malthusian scarcity due to eventual exhaustion of available resources, is nearly as nauseating to me as the prospect that civilization will sputter out and leave us confined forever to the Earth. Or maybe not, maybe 'civilization' expands from there and does the same thing to every other star in the Galaxy, like a plague that eats stars.

Much of the spiritual malaise of our age is because we have turned our eyes from beauty. Beauty can't be measured, it doesn't fit on a spreadsheet, so it doesn't exist at the corporate level. One of the defining characteristics of the cosmos is that it produces beauty in nearly infinite variety. Every natural landscape is beautiful in its own way, seen with the right eyes. Biological life invariably multiplies that natural beauty. Intelligence can go either way: it can produce incredible beauty when it works in partnership with nature, and it can produce abominations when it paves over nature.

People say we must go to space to become wealthy. What is the point of wealth without beauty? Or they say we must go to preserve conscious life in the universe. Again, what is the point of consciousness, if not to serve as the witness of beauty? Beauty may not be the only thing of importance, but without it life ceases to be life and becomes mere existence. We should go to space not just to enrich ourselves or to preserve ourselves, but with the intention of working in partnership with the universe to render it more beautiful.

I think such a motivation will provide much greater to impetus to exploration and settlement in the long run, because again, what's the point of interstellar expansion? Is it just feeding an insatiable appetite as we try to outrun the heat death of the universe by converting every available kilogram of it to human biomass? There's no way to win that game.

We should make ourselves the gardeners of worlds, not their destroyers.

[ne digga (bio/acc) @nedigga3]

@YosefGamil @MethuselahLab @LaurieGreen36 i really hope so...

do you think we need AGI or a technological singularity for that?

[ne digga (bio/acc) @nedigga3]

@YosefGamil @MethuselahLab @LaurieGreen36 do you think we will see it this century?

[ne digga (bio/acc) @nedigga3]

@BowTiedPhys which shows us that VO₂ max is not as accurate a biological age marker as some people think

[ne digga (bio/acc) @nedigga3]

right, lowest all-cause mortality is at 10-12 years, so we'd aim for that range cellularly

on an organismal level you'll probably remain post-pubertal in a way, as we won't reverse large-scale anatomic and structural maturation (e.g. fused growth plates, sexual organ maturation etc.)

so it will be an amalgamation of pre-pubertal cellular age, post-pubertal organismal phenotype and lifelong cognitive-emotional-spiritual maturation, which is quite beautiful to imagine

[ne digga (bio/acc) @nedigga3]

@Iammarcmalone many post-medication disease states are local minima in the epigenetic landscape

neuronal partial reprogramming could be curative here

let's see what ER-100 does in retinal cells and hopefully we'll move towards the brain from there

[ne digga (bio/acc) @nedigga3]

@justalexoki Zinc 4 x 25 mg per day
Vitamin C 4 x 500 mg per day
NAC 4 x 1200 mg per day

Povidone-Iodine Gargle & Nasal Spray every 4 waking hours.

Sleep, hydrate. Watch cold disappear in 24-72h.

[ne digga (bio/acc) @nedigga3]

@skdh it is B6 and specifically the pyridoxine form that can cause these neuropathies

the pyridoxal-5-phosphate form of B6 doesn't seem to cause it and even helps neuropathies

[ne digga (bio/acc) @nedigga3]

@heart_ lim t -> infinity
earth for the normies
space for us