Greg Neely

lets help protect and support each other this is a really hard time for us all. Personal account / my views.

[Greg Neely @Neely_Lab]

1 / 9
New preprint! We show that intranasal nose drops of mRNA-LNP can deliver therapeutic peptides to the brain, and we used this to reduce pain and increase social behaviour in mice. This could be a whole new class of non-opioid pain treatments. https://t.co/tET1GDVKZP 1/9

[Eric Topol @EricTopol]

There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
https://t.co/e04jqJMPw0

[Greg Neely @Neely_Lab]

10/ This is a platform. BDNF (and Oxytocin previously) is our proof of concept, but the same approach should work for other secreted proteins relevant to brain disease.

This is a preprint not yet peer reviewed, feedback welcome.

[Greg Neely @Neely_Lab]

1/ New preprint from the lab, led by Maria Bergamasco!

We've developed a way to deliver BDNF directly to the brain using nose drops. Weekly dosing rejuvenates an old mouse's brain and blocks memory loss in a mouse model of Alzheimer's disease.

https://t.co/bY8cg2QMi1

[Greg Neely @Neely_Lab]

9/ A paper out in ACS Nano from Yu, Deng and colleagues (Cheng, Teng, Wei labs) shows the same general approach works in a different disease setting. Two independent groups, different disease models, same conclusion: intranasal mRNA-LNP of neurotrophic factors works.

[Ronald Jenner @evolriffs]

If you want to join us for the venom GRC in Barcelona next month, late registration is open until Sunday this week. Don't miss it! https://t.co/GY5Ydds6Hn…

[Greg Neely @Neely_Lab]

Great work from co-first authors @LLTheResearcher and Kazuma Fujikake and the whole team @CPC_usyd @Sydney_Science @UNSWRNA, @CSIRO and @UofT.

This is a preprint and not yet peer reviewed. We look forward to feedback from the community!

https://t.co/tET1GDVKZP

[Greg Neely @Neely_Lab]

1 / 9
New preprint! We show that intranasal nose drops of mRNA-LNP can deliver therapeutic peptides to the brain, and we used this to reduce pain and increase social behaviour in mice. This could be a whole new class of non-opioid pain treatments. https://t.co/tET1GDVKZP 1/9

[Greg Neely @Neely_Lab]

We're now moving this technology towards commercialization and human trials through our spinout company Enhanced Analgesics. We've shown this works across multiple animal models — the next step is getting it into the clinic. 8/9