Neil O'Sullivan

PhD student @bioucc | Interested in Heme, Autophagy and Innate Immunity | He/ Him.

[Nathaniel David @NathanielEDavid]

Cancer patients waste away partly because their own fat starts burning itself. The signal that starts it is not a cytokine. It is iron. Could this insight lead to a drug to prevent cachexia in cancer patients?

https://t.co/pkuD6gEyKW

[Hijiri Oshio @research_Hijiri]

Thrilled to share our recent paper in Nature Cell Biology!

We identified mitochondria–ER contact sites as a haem-derived iron supply hub to mitochondria.
I’m grateful to everyone who supported this project throughout my PhD journey.

https://t.co/h0RSZDZ8Yi

[BioIronSocial @BioIronSocial]

Time to discuss Hemochromatosis and its prevalence in Ireland at the European Iron Club 2026 #EIC #HFE #Dublin

[nature @Nature]

Nature research paper: Proteasome-guided haem signalling axis contributes to T cell exhaustion

https://t.co/n5NnNRSbcU

[Cell Biology J-Club @cell_club]

The ATG8 E3-like ligases sense lysosomal damage and initiate ESCRT-mediated membrane repair
https://t.co/QLaQXm8Ppj

[Vijay Rathinam @RathinamVA]

Structural features underlying LPS recognition by caspase-11/4 and the activation of the noncanonical inflammasome. Congrats to Chengliang Wang
@WC8484667356490 & Jianbin Ruan @jianbin_ruan @uconnhealth Happy to contribute to this exciting paper! https://t.co/e5pokwCfpn

[John Lukens @LukensJohnR]

Tumors hijack macrophages for iron supply to promote bone metastasis and anemia @CellCellPress https://t.co/LzARFQcKo0

[Cell Biology J-Club @cell_club]

Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis: Developmental Cell https://t.co/mwOwyKB1wg

[Nature Rev Immunol @NatRevImmunol]

Iron and the immune system https://t.co/vV9PqNiMxK

[nature @Nature]

Nature research paper: Maternal iron deficiency causes male-to-female sex reversal in mouse embryos

https://t.co/lvpTUoZQ65

[Oriol Pich @oriol_pich]

🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton + more
https://t.co/PYUKWzSxV2

[Cell Biology J-Club @cell_club]

Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization
https://t.co/UJPf8f40aU

[Waggoner Lab @LabWaggoner]

Solute carriers: The gatekeepers of metabolism @CellCellPress @KivancBirsoy
https://t.co/Ewt7f0QonF

[Savas Tay @SavasTay_UChi]

Do macrophages remember signals they have previously seen? Our latest paper in Cell Systems:
https://t.co/gE7ZScxYb8

[Journal of Experimental Medicine @JExpMed]

Lee, Benoist et al. @harvardmed profiled all immunologic cell types by RNAseq after systemic exposure to IL1β, IL6, and TNFα, revealing highly redundant cytokine network, with intertwined effects between disparate #cytokines and cell types. https://t.co/jaYfnSVCmH
#Inflammation

[Massimiliano Stagi @MassimilianoS16]

Our new study: https://t.co/9FFyqtdlxG. It provides useful tools for studying LLOME lysosomal damage. Plasmids will be available soon on @Addgene.

[jan homolak @JanHomolak]

Our short piece highlighting the impressive work by @microbetracker on how the Parkinson’s disease drug entacapone disrupts gut microbiome via iron sequestration. @lab_maier
https://t.co/83UVb6hBMs

[Celeste Karch @karchlab]

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis https://t.co/3CMiexfB9E

[John Lukens @LukensJohnR]

Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier | Science Translational Medicine https://t.co/hng5EvyuoB

[BioIronSocial @BioIronSocial]

Big news within the BioIron Society! For the first time the BioIron has a Junior Board. Trainees researching in the iron field have been selected to join the Junior Board, which will organize educational events and initiatives for trainees!

https://t.co/7ke4OJRIXg