Shiva N

Founder & CEO of ARIA Therapeutics, MD-PhD. My posts are my personal opinions. she/her

[Peyman Milanfar @docmilanfar]

https://t.co/XUSxYcCigT

[Broad Institute @broadinstitute]

Prime editing has continuously improved since @davidrliu's lab introduced it in 2019. 3 new studies from his lab advance prime editing systems, addressing key bottlenecks by increasing the efficiency and improving its potency when delivered into the body. https://t.co/r9qYb2eaXb

[Shiva N @NickSh85]

@ihteshamali AI can accelerate the process and make our efforts more efficient but only when it's trained on reliable data. If we truly care about curing diseases, we need to merge with AI to make that breakthrough.

[Shiva N @NickSh85]

@BLLPHD AI can accelerate the process and make our efforts much more efficient, but only when it's trained on reliable data.

[Shiva N @NickSh85]

@TonyRobbins So true and well said

[Revolution Medicines @RevMedicines]

RASolute 302 Phase 3 results were presented at #ASCO26: All primary and key secondary endpoints met for previously treated metastatic pancreatic cancer. Results published in @NEJM. https://t.co/S2kqk0bB4s

[Samuel Hume @DrSamuelBHume]

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results

I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

[Kenneth Loi @kenjmloi]

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.

We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.

Thread + link below.

[Shiva N @NickSh85]

@earthcurated Here’s to our generous beautiful planet💙🩵🤍

[Earth @earthcurated]

Today is National Earth Day.

[Google Research @GoogleResearch]

Introducing TurboQuant: Our new compression algorithm that reduces LLM key-value cache memory by at least 6x and delivers up to 8x speedup, all with zero accuracy loss, redefining AI efficiency. Read the blog to learn how it achieves these results: https://t.co/CDSQ8HpZoc

[Shiva N @NickSh85]

@StateDept_NEA Nowruz Pirouz 🪻🌷🌹
May this Nowruz truly bring that triumph.
May light prevail where darkness still lingers.
May peace and human dignity reach all who long for them especially the people of Iran.

[David Jacobs @DrJacobsRad]

Happy Nowruz!

This year may all of the children of Cyrus the Great be free once more.

#IranRevolution2026‌

[Shiva N @NickSh85]

@docmilanfar Happy Nowruz 🪻🌷🌹

[The Lancet @TheLancet]

VEXAS syndrome is a newly discovered multisystemic disease affecting most organs.

A Review provides a comprehensive overview of VEXAS syndrome, including the disease's discovery, diagnosis, and treatment: https://t.co/2BPPLfwDD9

[Shiva N @NickSh85]

@mdubowitz 💚🤍❤️

[Fabian Theis @fabian_theis]

New paper in @ScienceMagazine with Schoof & Porse labs: We chart early human hematopoiesis using single-cell proteomics, and amongst others developed a dynamic model linking RNA to protein levels, explaining more proteomic variation.

📄 https://t.co/Lwdof1SVAK

[Shiva N @NickSh85]

So grateful for this recognition! Thank you @LeukUK and @Dr_Valletta for your invaluable support! 🧡

[Valletta Group @SVallettaGroup]

Very proud moment - yesterday, our brilliant postdoc was awarded the Poster Prize at the @LeukUK Annual Science Seminar! @NickSh85, congratulations on this well-deserved achievement 🧡

[Simona Valletta @Dr_Valletta]

Thank you to @LeukUK for supporting our research! And well done, Shiva! @NickSh85 🤩

[Marios Georgakis @MariosGeorgakis]

Most genetic variants associated with human disease are assumed to act by influencing gene expression.

Expression is regulated at the cell level, but most resources linking variants to expression come from tissue-level data

Two advances in the world of single-cell eQTLs🧵 1/9