Nicole Sono

[Nicole Sono @NicoFootA]

I disclosed that I have a Glioma brain tumour affecting my speech and strength. Instead of support, I was told to “try again” and then told I “didn’t have the guarantee” — even after showing evidence. How is this acceptable for a no‑questions‑asked benefit?

[Nicole Sono @NicoFootA]

@opodo I was told to call back — I did.
Told to wait — I did.
Told to follow steps — I did.
Yet I’m still no further forward. My Prime Plus guarantee was confirmed, so why can’t you honour the 80% refund I paid for?

[Nicole Sono @NicoFootA]

@opodo 24919934048 my booking ref!! What do I have to do to get someone to reply to me? 80% Credit refund GUARANTEE! The full reason I booked with you in the first place. I am utterly disgusted with how you treat your customers.

[Nicole Sono @NicoFootA]

@opodo After multiple calls, evidence provided, every step followed, I’m still being denied the Prime Plus no‑questions‑asked 80% refund I paid for. I’ve been given contradictory information, redirected repeatedly, left without support despite disclosing a Glioma brain tumour.

[Nicole Sono @NicoFootA]

@opodo I followed every instruction your agents gave me. Called back. Waited. Tried again. Provided proof. My guarantee was clearly applied, yet you still refuse the 80% refund. I disclosed that I have a Glioma brain tumour affecting my speech and strength. Instead of support - 0

[Nicole Sono @NicoFootA]

@Opodo I selected the Prime Plus “cancel 2 flights for any reason” guarantee — a no‑questions‑asked benefit — and you are refusing to honour the 80% refund despite me meeting every condition. I’m a vulnerable customer with a brain tumour and spent 2 hours on the phone TWICE

[Charlie Lees @charlie_lees]

I don't think diet is THE cause of IBD

But there is good epidemiological evidence now that the modern western diet is on factor contributing to the global rise in IBD. Some dietary factors may be drivers of inflammation rather than causative.

The role of dietary therapy in treating inflammation is established through exclusive enteral nutrition

Data for other dietary strategies is weaker.

A Mediterranean style diet is recommended if this is available locally and affordable.

A Mediterranean diet is typically prepared from fresh whole foods, minimally processed, with fruits, vegetables, leans meats, healthy fats and whole grains. Produce is typically season and local. Meals are enjoyed socially with family and friends. Physical activity and time in nature is also encouraged

IBD clearly a global problem arising across many cultures with a multitude of local cuisines. This gives us an opportunity to share knowledge and learn from each other.

For many people improving diet quality will have a profound impact on how they feel - including improved mood, sleep quality and energy levels.

Important additional considerations:

About 25% of IBD patients will also have a degree of IBS

Dietary fibre typically needs to be restricted in
• stricturing small bowel Crohn's disease
necessitates a low fibre diet
• during acute flares of colitis

[Nicole Sono @NicoFootA]

Hey,
Treat yourself to something special from Club L! Here’s £10 off your first order when you spend £50. https://t.co/6EMpSEvwIm

[Nicole Sono @NicoFootA]

@charlie_lees Stunning photos 😍

[Nicole Sono @NicoFootA]

@marksandspencer ruined my Christmas 💔 bronze turkey best before 26th, off!!!! Soon as you opened it the smell was so foul we were physically sick…. Ruined Christmas dinner 💔 heart broken

[Charlie Lees @charlie_lees]

The brain and body are more intertwined than we knew

There is a bi-directional relationship between brain and gut

Implications for managing inflammatory bowel diseases ...

Control stress and inflammation may improve

Also for brain disorders, where treatments mediated via the gut may be beneficial (e.g. MS, Parkinson's, Alzheimers's).

[The Secret @thesecret]

The fastest way to attract anything is to give. So if you want money, give it. It doesn’t matter how much or to whom, just give.

[Charlie Lees @charlie_lees]

Why are we still failing our IBD patients?

Let's focus our efforts together to make big breakthroughs for treating IBD patients

Nine areas we should focus on:

1. Building a solid evidence base

The basis of all that follows

We would not be allowed to use a new drug therapy unless it passes rigorous testing in randomised controlled trials.

This should apply to dietary and microbial strategies too.

We also need robust data to inform which molecules, diets, bugs, monitoring strategies, etc to take forwards.

2. Fistula and stricture therapy

The failure of mesenchymal stem cells in perianal Crohn's disease (ADMIRE-2) highlights the need for renewed focus here

Stricture therapy remains almost entirely with mechanical solutions

Great innovative work and leadership in this space by @NickPowellLab @ibdseb @IBD_FloMD @AmyLightnerMD and many others here

3. Microbial and dietary strategies

The therapeutic ceiling for IBD is depressing low and we are only nudging it upwards with new targeted drugs

Huge progress will come once we layer in microbial and dietary strategies on top of drugs

There is progress here - @ProfWhelan and @BenoitChassaing lab working on emulsifiers is super exciting

Full data from @predicct coming soon too

4. Rational combinations of therapies

We hear chat about combination therapy ALL THE TIME

So ... what's the big deal?

Learning from other diseases (e.g. viral hepatitis) and our failure of precision medicine, an obvious approach is to target multiple pathways at once

Will it give true synergy?

Or will we simply double our changes of getting one right drug to a patient

VEGA data are very promising.

More to come, but RATIONAL design please!

5. Special populations: children especially

There is too big a lag on building solid evidence and gaining approvals for new therapies in children.

Solid evidence required for other situations with new drugs, e.g. acute severe colitis

Our paediatricians are wonderful colleagues

6. Delivery of high-quality care to all patients

Equity of care requires: awareness, prioritisation, funding, and effective systems

We have miles still to travel here

Learning from @ibdseb @DrCoreySiegel and others here

More leadership required from ECCO and other key stakeholders I feel

7. Biomarker discovery to enable precision medicine

We will get there, but it is depressingly slow

High resolution transcriptomics with single cell sequencing

PLUS dynamic biomarker trends over time

AND new AI driven analytics will ensure we make progress soon

Excited to see new data from @Dr_James_Lee @bverstockt @DrTineJess @DrChrisLamb @IBDNathan @anderson_carl and others here

8. Psychological and holistic approaches to enhance care

The brain and the gut communicate in a bi-directional manner

Therefore we must not neglect the brain

This means: stress management, optimal sleep, improved resilience, and much much more

Plus a focus on diet, relationships, intimacy, work, studies, exercise

Looking forward to data from @IBDBOOST

9. Frictionless and passive monitoring that work for patients

If you have diabetes, you can monitor your blood glucose continuously via a patch and via an AI algorithm you can change lifestyle and get the right dose of insulin

If you have IBD you need your faecal calprotetin measured on an intestinal ultrasound

We can't go wondering around with a rectal catheter in, providing continuous calprotectin measurement

So we need innovation - calprotectin wipes - smart toilets and others I cannot yet imagine

Something for ambitious young founders @zincvc

[Law Of Attraction @The_Secret_Law]

Be the one who nurtures and builds. Be the one who has an understanding and a forgiving heart. Be the one who looks for the best in people. Leave people better than you found them.

[Nicole Sono @NicoFootA]

@AldiUK I have short bowel syndrome and since having more surgery I’ve struggled to gain weight until I tried Aldi golden puffs. Now I can’t find them in any stores at all 😢 they helped me gain weight and didn’t hurt me. Please bring them back 😢😢😢

[Nicole Sono @NicoFootA]

@askdepop So they are receiving my messages but choose to be completely ignorant and not reply. I was told after 48 hours I would have a reply and it’s now after that time scale and I’m still waiting. I need to get this sorted as soon as possible. As you understand it’s almost Christmas

[Nicole Sono @NicoFootA]

@askdepop can someone please get back to me to explain why I’m having to wait even longer for my buyer protection to protect me from being sold a counterfeit item on your app? Seems to me that the seller whom has defrauded me of £562 sending a fake Louis Vuitton handbag, is more

[Nicole Sono @NicoFootA]

@askdepop He put on his add. Where would that leave me? You have no way of checking his receipt is real. You can however check that this is counterfeit and refund me the money that I was defrauded, yet you put the seller first

[Nicole Sono @NicoFootA]

@askdepop I also feel that in the way in which @depop deal with these situations is extremely poor. You quote in your terms and conditions that all counterfeit items are refunded. You have asked the seller to prove the item is real yet I have the item, he could provide a fake receipt like

[Nicole Sono @NicoFootA]

@daniwilliamson @askdepop I would also like a reply @askdepop either via Email or to one of your many platforms.