Code script

Code script

[Sam Sinai @samsinai]

>50% primate brain, >80% primate muscles, and every layer of the primate retina.

[Prof. Nikolai Slavov @slavov_n]

Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences.  Our @Nature article demonstrates that these predictions miss thousands of protein sequences present in human tissues.

Across >1,000 human samples, we identified numerous abundant proteins whose amino acid sequences differ from those predicted by the genetic code.

These proteins are not rare translation byproducts. They accumulate to thousands of copies per cell. Some are more abundant than the proteins predicted by the genetic code from the same transcripts.

Their abundance reflects a combination of alternate RNA decoding mechanisms — including codon-anticodon mismatches, tRNA abundance, and RNA modifications — and selective stabilization of the resulting proteins. The last factor – protein stability – emerges as a major determinant of protein abundance across proteins, proteoforms and cell types: https://t.co/IzOfAZKnxT

Alternate RNA decoding is pervasive across functional groups of proteins, healthy and diseased tissues. It affects proteins playing key roles in neurodegeneration, and some alternately decoded proteins show strong enrichment in tumors compared to their surrounding tissues.

This discovery has been a long and exhilarating journey with Shira Tsour and the @slavovLab team. It started in 2019 and proceeded through many challenges and thrilling highs. A journey that has opened new perspectives that we long to explore!

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[Jennbrophy.bsky.social @jennbrophy7]

Excited to share our new preprint "Genetic code expansion enables plant-directed control of bacterial activity", a fantastic collaboration with @kunjapur lab!

https://t.co/JDQZfRkpzY

[Filippo Caschera @Stjle]

PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized proteins

https://t.co/YFzHWQSfxM

[BioFaction @BioFaction]

Apply to the Microbial Fuel Cells MudTronics competition: https://t.co/9NimkCyJ4P

MudTronics is a collaborative competition that brings together bio, tech, and art/design to explore what we can do with microbial fuel cells.

Deadline June 6th, 2026

[Harris Wang @harriswangnyc]

1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia
https://t.co/ZT3Ygw9tiG 🦠🧬🛠️🖥️💥

[Hideaki E. Kato @emeKato]

https://t.co/LutbBphd4G

これはreverse translationの入口と言っても良いのでは・・・？こんな驚きのタンパク質が自然界から見つかってくるからこそ、遺伝子マイニングはやめられませんね。。

[Shixian Lin @Linlab_ZJU]

Excited to share our new paper in @NatureChemistry!

Building on our Rare Codon Recoding (RCR) work @ScienceMagazine, we developed a multi-rare-codon strategy enabling the simultaneous incorporation of up to 5 distinct ncAAs in mammalian cells!

https://t.co/tLp3wZTQ9U

[Devon Stork @StorkDevon]

What's great about this is that we can finally start putting numbers on the big questions in terraforming research. https://t.co/ztzkF3CAKD

[Matthaeus Schwarz-Schilling @matthschwa]

Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method
by Miyachi, R., Masuda, K., Shimizu, Y., Ichihashi, N.

https://t.co/lO0PBPcRuz

[Code script @nonstandardcode]

Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water
https://t.co/gIwgob0U2O

[Sebastian S. Cocioba🪄🌷 @ATinyGreenCell]

If you are an highschool student and you are conducting research in a lab, you are a scientist.

If you are an undergraduate student and you are conducting research in a lab, you are a scientist.

[Code script @nonstandardcode]

Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids

https://t.co/WFOmxDhlsa

[Princeton Chemistry @PrincetonChem]

Michelle Chang of @PrincetonChem and colleagues publish in @NChemBio: “Terminal alkyne formation by a pyridoxal phosphate-dependent enzyme.”

Great work! https://t.co/DRkPaXNYyc

[Code script @nonstandardcode]

From the chin lab

Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism | Biochemistry https://t.co/izckgUWPgj

[Matthieu Gagnon @gagnon_lab]

2 of 2: Instead of activating a water molecule for hydrolysis, as previously thought, release factors induce a structural change in the transfer RNA, enabling its own 2’OH group to attack and break the bond, a universal process in all organisms.
https://t.co/pnvjwTpz0V

[Structure @Structure_CP]

Online now! The continuous evolution of biomolecular force fields https://t.co/hjqGxVYJgF

[Stephen Tang @stephentang23]

Excited to share our newest paper, online today @Nature! We report the discovery of a highly unusual mechanism of antiviral immunity through the synthesis of long, homopolymeric DNA.

https://t.co/0TV9jrPWrs

[Patrick Bryant @Patrick18287926]

There is also a Colab notebook for EvoBindRare now! Try it and let us know what you think: https://t.co/ZnRPRe7lFR

[Chang Liu @chang_c_liu]

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to @yuichi_furuhata, a true master bioengineer, on leading this excellent work! https://t.co/2iYPAg0yq8