Warmest congratulations to Nobel Laureate, David Baker! We are so incredibly proud of you and your contributions to the field of protein design. Onward and upward!
This year’s chemistry laureate David Baker created the first protein that was entirely different to all known existing proteins.
The protein, Top7, was a bolt from the blue for the researchers working on protein design. Those who had previously created new proteins had only been able to imitate existing structures. Top7’s unique structure did not exist in nature. Also, with its 93 amino acids, the protein was larger than anything previously produced using de novo design.
#NobelPrize
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
More EvoPro applications to come! Until then, you can find the code on the Kuhlman Lab GitHub.
Happy designing! 😊🥼
⚙️https://t.co/k4foLpeXfX
📖https://t.co/1F0QoMTd8u
SO excited to introduce EvoPro, a protein design pipeline that iterates bw structure prediction & seq diversification that engineered a ... 1 nM binder (design 5)! This was a huge group effort, made possible by @amritanalla, @tkinjo8 , Nick, and Brian. 🥳
Besides finding a ⚖️ bw affinity & protease-dependent activity, the coolest aspect of the best performing masks is just how diverse the structures and interface contacts are from each other & from the natural ligand (⚫️). 😎🤓
“For the 20 years that we worked together before anybody knew about us or cared it was literally the two of us sitting side by side at a bench and working together.
Usually at 3 or 5am we would be emailing each other with new ideas.”
- 2023 medicine laureate Drew Weissman on his partnership with his co-laureate Katalin Karikó.
Keep an eye out for our telephone interview with Weissman, coming soon!
I'm super excited to present my research on interface design to the incredible @ProteinBoston community!
Make sure to stop by and say hi! ☺️👋
Special thanks to the amazing organizers @bahl_lab, @nickpolizzi_ , and @sokrypton 👏
we can't wait for our seminar next week by @oda_sci!
"Computational design of autoinhibitory domains for a protease-activated PD-L1 antagonist"
Wednesday, September 13th, 7pm EDT
Room B101, Northwest Building @Harvard
check out https://t.co/E8bDyGzirb for more info 👇
What made month one so fun? New biology, new pipettes, a never ending supply of 🍩s, attending @ProteinBoston with my grad school rotation mentor, engaging discussions, and even a little champagne!🍾🥂
I'm so happy to share that I joined @AI_Proteins as a Scientist on the Discovery Team!🦋I'm excited to create a healthier world by harnessing the power of miniproteins! It's been an incredible first month, with much more to come. Until then, some pics of happy scientists! 🧬