Freesiaming

[Eric Topol @EricTopol]

The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer.
✓ out the new Ground Truths (link in profile)

[Matt Disney @disney_lab]

Excited to share our latest paper: https://t.co/qBsVg1c0Hz
Congrats to Chungen + great collaboration with the Batey lab. Covalent bioactive ligands to RNA described >10 yrs ago... need to move faster.
Key points in this study:
• Chirality matters for RNA covalent ligands
• In situ epoxide formation → hydrolytically stable adducts (incl. aziridines)
A more predictable framework for targeting RNA. More to come.

[Matt Disney @disney_lab]

A chemoinformatics-guided platform for efficient discovery of RNA-binding small molecules: Proof-of-concept for myotonic dystrophy type 1 | bioRxiv https://t.co/cvUBam6LX0

[Matt Disney @disney_lab]

Excited to share our new ACS Chemical Biology paper.
We show that a small molecule RiboTAC selectively degrades pre-miR-21 and rescues disease-relevant pathways in cellular models of fibrosis.
Another step toward drugging disease-driving RNAs with small molecules.
https://t.co/d0HgRFtcX6

[Eric Topol @EricTopol]

Whether there is a real impact of GLP-1 drugs on cancer is unresolved. If confirmed, it could simply reflect weight loss or, as seen for other conditions (e.g. heart, kidney), weight loss independent effects. We need dedicated trials to resolve this important question.
git link
https://t.co/4ybaxbsbya

[nature @Nature]

Exercise prevents brain ageing and memory loss by strengthening the blood–brain barrier

https://t.co/O7v9yALtI4

[Eric Topol @EricTopol]

Our retina image is so rich with information, a gateway to the whole body, well beyond the eye. Today add osteoporosis to the list.
https://t.co/wUUsOziecv
This adds to what I recently wrote about at Ground Truths https://t.co/fOsjLgAyvU

[Amazing Maps @amazingmap]

China Built the World’s Largest High-Speed Rail Network in Just 12 Years

[The Nobel Prize @NobelPrize]

"If you're working non-stop all the time you will burn out."

How do you keep a healthy work-life balance as a scientist? Hear 2009 chemistry laureate Venki Ramakrishnan share his best advice on how to achieve a good work-life balance.

#NobelPrize

[Terrible Maps @TerribleMaps]

The weirdest foods in each U.S. state

[Eric Topol @EricTopol]

Why do women account for nearly 2/3rd of all cases of Alzheimer's disease? A new, thorough review @jclinicalinvest, open-access, on its origins in midlife.
https://t.co/obITwhEiYG

[Retraction Watch @RetractionWatch]

Lawsuit fails to block retraction of paper claiming to link heart-related deaths to COVID-19 vaccines.
https://t.co/BegMWg23BN

[Amazing Maps @amazingmap]

China drawn only by roads

[FDA Drug Information @FDA_Drug_Info]

FDA approved a tablet form of semaglutide for weight reduction in adults with obesity or overweight. For complete prescribing information & safety data: https://t.co/OUgDXozeO7

[TasteAtlas @TasteAtlas]

Chinese cuisine elevates texture (kougan) to a high art form that often baffles Westerners, celebrating gelatinous, slippery, and cartilaginous sensations that western palates historically tend to reject. This obsession is encoded in the language itself, which possesses dozens of specific single-character terms for distinct mouthfeels—such as the bouncy Q or the slippery huá—whereas European languages would often require an entire sentence to explain the same complex physical sensation.

[Wertheim UF Scripps @WertheimUFScrip]

A new study in @J_A_C_S maps how the SARS-CoV-2 genome can be targeted by a new class of RNA-seeking antiviral molecules. From @Disney_Lab @UFScripps with @thechandalab and Arnab Chatterjee.
https://t.co/9V3ehC0cA3 @UF_Research @scrippsresearch

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Matthew Disney is talking about how to approach RNA as a target for small-molecule probes and drugs at #SLAS2020 - here's a perspective with more on this topic https://t.co/LYm3sIr37E

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells https://t.co/rUp92Opbx3

For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review https://t.co/4CVfcN5Y2r
https://t.co/z83V1d8cOQ

[Science Magazine @ScienceMagazine]

In a new #ScienceReview, researchers investigate how the recent application of single-cell RNA sequencing technology has helped to evaluate function in microbial populations. https://t.co/7ksVrreJXt

[Ishwariya Venkatesh @Ishwariya13]

I remember breaking down to my Ph.D. advisor about how stupid I felt while troubleshooting a problem in my project when she handed me this paper. Years later it is still relevant to young students starting off in Science. It's ok to feel stupid, we all do on a regular basis.