Pleased to share our review "Metabolic danger signals: TCA cycle metabolites regulate immunity and disease" @CellChemBiol.
@Lo_Zanzi and I discuss how TCA cycle metabolites act as metabolic DAMPs to shape infection, inflammation, autoimmunity, and cancer. https://t.co/JEjhdsOHz5
https://t.co/Rz50flYpbd Wonderful work from my colleague (and friend before all) @mariasilvia0824 et al. on medRxiv uncovering the role of the risk variant rs485499 in the IL12A locus in SLE pathogenesis, and giving new insights regarding pathogenic Cytotoxic DN2 B Cells. Proud !
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🚨 New paper alert--just published in RNA!
Scientists often say anecdotally that RNA modifications are disrupted in immortalized cells — but no one’s really tested it.
So we did: ψ-mapping in primary T cells vs. Jurkat cells using direct RNA-seq.
📄 https://t.co/3iwfb2mIRV
#nanopore #RNA #pseudouridine #Tcells
🚨I am recruiting PhD students!🚨
(Please re-post this!)
If you are interested in #spatialNavigation, #fMRI, #aging, #virtualReality, #AlzheimersDisease and more, please consider applying to work with me!
IMPORTANT: Please email me prior to applying!
High altitude flow cytometry! First time coming back in Italy since April for the holidays, I feel extremely grateful to whom is making this possible everyday, my mentors @Lucia96107702@Lo_Zanzi. See you soon!
What is the effect of #COVID19 vaccination on platelet activation?
In this #RPTHOriginalarticle Dr. Maiorca et al report that vaccinated individuals have:
⛔️No platelet hyperactivation
✅ platelet-leukocyte aggregates that foster immune protection.
https://t.co/baldpwkv0b
New paper alert‼️ #ImmunoMetabolismPower#EpigeneticPower! Excited to share our latest paper showing that host-derived oxidized phospholipids produced in response to pathogen encounter initiate effector-triggered immunity & cause the death of the host 1/9 https://t.co/Eox55TKRnP
Vaccination may be limiting excessive immunothrombosis by accelerating virus containment during COVID-19 infection. This results in deferent circulating platelet-leukocytes aggregates in disease severity-stratified patients. Read it now on @RPTHjournal@Lucia96107702
Yesterday got some job done in the beautiful #NYC before getting the train for #Boston@Harvard@harvardmed & ready to have fun & doing my best to support the best #science at an @NIH study section today!
Very cool study: ancient antibodies were recovered from the teeth of a Medieval individual, and some of those antibodies were still able to bind parts of Epstein-Barr virus! EBV is a great proof-of-concept: it's shed in the mouth and is incredibly common. https://t.co/ScDqJAZwWO
#InterferonPower! @Lloyd_Bod @kuchroolab &co show @Nature that deleting Tim-1 in #Bcells increases their response to type I IFNs thus potentiating antigen presentation to T cells, & driving anti-#tumor effector T cells that control cancer! https://t.co/LHnr079GGl
Scientists of Twitter! The world needs more reminders that we're living, breathing human beings.
Quote tweet this with a picture of you doing not-science.
It’s a new dawn, it’s a new day, it’s a new life! 🌄 Welcome to our new spectral cell sorter #AuroraCS by @CytekBio. Acquired thanks to @SapienzaRoma funding for instrumentation