Debasish Paul

A Science enthusiast, SME Protein homeostasis, Assay development, Cell and molecular biologist, #postdoc @NIH-NCI

[Debasish Paul @paul6589]

Ever wonder how cells manage their energy for rapid growth? Our new @Nature paper reveals a key trick! We found how #mTOR signaling temporarily turns down a cell brake (APC/C) to create a vital burst of #glycolysis, essential for cell cycle entry. #Cancer #Cellcyle #metabolism

[Steve Cappell @steve_cappell]

Check out our new paper led by @paul6589 out now in @Nature. Cells need a boost of energy to jumpstart the cell cycle, but how can this happen while the APC/C is actively inhibiting glycolysis? Cells solve this paradox through a highly dynamic mechanism.
https://t.co/XdwY1v3TC9

[National Cancer Institute @theNCI]

A new NCI study revealed a previously unknown "on-ramp" for cell division. Researchers found that the enzyme APC/C briefly switches on and off as cells prepare to divide—a discovery that could inform future strategies to target cancer growth and drug resistance. https://t.co/5drrGYZq1N

[Debasish Paul @paul6589]

@DipaLab_IISc Congratulations @dipalab_iisc

[Debasish Paul @paul6589]

@amitesh1anand @MerckIndia @tapomoy89 @Jogender_Singh7 @rajesh_gokhale @TIFRScience Congratulations team @amitesh1anand

[Debasish Paul @paul6589]

@iiscbangalore @Sachin_mitosis Cool work @Sachin_mitosis lab!

[Ryan Potts @pottslab]

What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology. https://t.co/nfP5GV696s
#mycompnay

[Debasish Paul @paul6589]

@syncellbiolab @embojournal @Jayantikri23 Great work @syncellbiolab, congratulation!

[nature @Nature]

Nature research paper: Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry

https://t.co/aQV0zKComB

[Cell Biology J-Club @cell_club]

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
https://t.co/0pVHdFSLTa

[Debasish Paul @paul6589]

@KamatLab_IISER @SanjeevSaGa @SnehaTripathi28 @IISERPune @OncotargetJrnl Congrats to the team for this awesome work! @KamatLab_IISER @SanjeevSaGa

[Debasish Paul @paul6589]

@UllasKolthur A commendable initiative! Advancing our understanding of nutrition and metabolism is crucial for shaping a comprehensive approach to development and disease prevention. Wishing it a great success!

[Broad Institute @broadinstitute]

We’re thrilled that base editing, developed by researchers in the lab of Broad member @davidrliu, is having such a profound impact in the clinic. Congratulations to former Broad postdoc @kiranmusunuru and @ChildrensPhila for their groundbreaking work. https://t.co/jTQJ69aTST

[Debasish Paul @paul6589]

@davidrliu Great! Congrats to you and all your team and collabs @davidrliu

[Debasish Paul @paul6589]

@DBT_CDFD @DBTIndia @UllasKolthur @BhandariRa50794 Congrats @BhandariRa50794, a well-deserved one.

[Debasish Paul @paul6589]

@RamrayB Commenting for better reach :)

[Debasish Paul @paul6589]

@amitesh1anand @TIFR_Bio @DBTIndia @TIFRScience Congrats Amitesh and Group!

[Debasish Paul @paul6589]

@DebdeepDutta21 @IITKanpur Congrats @DebdeepDutta21 and @IITKanpur

[Debasish Paul @paul6589]

@xinzhoulab Great work, @xinzhoulab! Excited about the CAR-TransTac! Congratulations!

[Debasish Paul @paul6589]

@arshukla looks like " Elon reeve musk" is getting interested in GPCR :P