Paul Thomas

Bioanalytical Chemist, Dadx3, baseball fan, outdoorsman

[Paul Thomas @Paul_M_Thomas]

@CaTFFranco Xevo G2 or Agilent 6230

[Paul Thomas @Paul_M_Thomas]

@fireinlab @ItsBiniR I automated this years ago on a ltq-ft. Network controlled relay wired in parallel with that little black switch!

[Paul Thomas @Paul_M_Thomas]

@Popher @vanaernum @UCDProteomics @veritasium More specifically to Jack Beauchamp's lab at CalTech

[Paul Thomas @Paul_M_Thomas]

90 minutes now @Avis ... You can #DoBetter

[Paul Thomas @Paul_M_Thomas]

Hey @Avis, can we get a few more rental agents in Albuquerque. Been waiting over an hour and still have probably another hour to go. #DoBetter ... averaging 8 minutes per rental. One person at the counter

[Paul Thomas @Paul_M_Thomas]

@VATVSLPR @ItsBiniR I agree. Mass defect makes no sense. These are almost certainly electronic noise.

[Paul Thomas @Paul_M_Thomas]

@NorSivaeb What about isoAsp? Appropriate here?

[Paul Thomas @Paul_M_Thomas]

@NorSivaeb *proline amide

[Paul Thomas @Paul_M_Thomas]

@NorSivaeb This does happen in therapeutic Mabs expressed in CHO cells. When the lysine is cleaved, you're left with c terminal PG that can be converted to a terminal propone amide... But not super common outside of that case I'd bet https://t.co/aIejWHneTf

[Paul Thomas @Paul_M_Thomas]

@hailceezur @JMU @JMUChemistry Congratulations and enjoy the beauty of my home state and the Shenandoah valley!

[Paul Thomas @Paul_M_Thomas]

@GarciaLabMS Industry people are too busy... Sadness. Go team biotherapeutics!

[Paul Thomas @Paul_M_Thomas]

@JohnRYatesIII @yingge2121 @GarciaLabMS @TopDownProteome https://t.co/uGMmUrkZBt

[Paul Thomas @Paul_M_Thomas]

@MoweiZ @JoshuaSSharp I spent the summer before my first year of grad school with @NLKProteomics deep inside the ion optics of an 8.5T FTICR. Love digging into instruments!

[Paul Thomas @Paul_M_Thomas]

@andy___jones Is it from a gel? Or was it near acrylamide at any point? I've seen +71 from hand cast sds-page before.

[Paul Thomas @Paul_M_Thomas]

@HicksLabMS Given "Made in Singapore" and box size, I'm guessing an Agilent TOF of some sort?

[Paul Thomas @Paul_M_Thomas]

Looking for a career in large molecule drug development? Want to apply your skills in LC, CE and MS to characterize Mabs and ADCs? Come work with our team in ARD @AbbVie Apply for the position below or DM me for more details.
https://t.co/eG1igTOrHP
#chemjobs #pharmajobs

[Paul Thomas @Paul_M_Thomas]

@GarciaLabMS Hg

[Paul Thomas @Paul_M_Thomas]

@czech_ms @NobelPrize @cunicz Looks like a mercury mass spectrum to me! Fitting given Heyrovský’s contributions to electrochemistry and the dropping mercury electrode!

[Paul Thomas @Paul_M_Thomas]

@sabbatiello0310 A "clothed" Bayard-Alpert style ion gauge. A consumable part often found in some of the least accessible spots on a modern commercial mass spectrometer... Looking at you TSQ Quantum...

[Paul Thomas @Paul_M_Thomas]

@sabbatiello0310 Rare to see one apart without carnage!