Paul W Chrystal

Postdoctoral Fellow at the University of Toronto studying inherited retinal dystrophy.

[Paul W Chrystal @PaulWChrystal]

How does one gene perform different functions in different tissues? Our new publication in @CommsBio sheds some light on the disparate roles of Usher Syndrome disease gene PCDH15. https://t.co/dZoIN3aDsW

[Paul W Chrystal @PaulWChrystal]

Congratulations to Andrés Avelar for winning the F Michael Barrett Award for best poster today at @UofTCellSysBiol! You've worked super hard over the last 4 months in the Tropepe lab and truely earned this accolade!

[Paul W Chrystal @PaulWChrystal]

Huge thanks to the talented students who helped me with this study (Ishmael, Alexa, Lisa, Daniel and Jefferson), my supervisors, and our funding partners @FB_Canada @usher1f.bsky.social

[Paul W Chrystal @PaulWChrystal]

How does one gene perform different functions in different tissues? Our new publication in @CommsBio sheds some light on the disparate roles of Usher Syndrome disease gene PCDH15. https://t.co/dZoIN3aDsW

[Paul W Chrystal @PaulWChrystal]

These results increase our understanding of Usher Syndrome pathomechanism and provide a valuable disease model of retinal disease. Follow-up studies will investigate the binding partners of pcdh15 to look for therapeutic targets.

[Paul W Chrystal @PaulWChrystal]

Thrilled to see Usher syndrome raised in parliament! @jomilne10 is doing amazing work in advocating for new research. Proud to see people from NE England making a big impact. #Ushersyndrome @MarkFergusonMP

[Mark Ferguson @MarkFergusonMP]

I look forward to meeting with the Public Health Minister to discuss what can be done to properly support those living with Usher Syndrome and their families...

[Prof Mariya Moosajee @MariyaMoosajee]

I am so thrilled to see #UsherSyndrome being discussed in @UKParliament!

Thanks to the hard work of @CUREUsher setting up an All-Party Parliamentary Group #APPG for this #RareDisease that causes deafness from birth & progressive sight loss, learn more 👉🏼 https://t.co/km7ysGf1X4

[Paul W Chrystal @PaulWChrystal]

Thank you @ARVOinfo and Dr Eric Pierce for your great keynote talk on the state of gene therapy in ophthalmology. #GeneTherapyResearch

[Moorfields Eye Charity @EyeCharity]

It's #MacularWeek !

@NCLNoel, research fellow from @MacDonald_lab, shares her findings on the effects of ageing and age-related macular degeneration-like changes in fish models.

[Michel Cayouette @MichelCayouette]

Early Career Scientists: if I can give one advice, find yourself a good and supportive mentor. Someone who will read your papers/grants, get you invited to speak at meetings, and support you in various ways, without being complacent. Don’t be afraid to ask, folks love to do this.

[Paul W Chrystal @PaulWChrystal]

@EyeCharity @NCLNoel Congratulations @NCLNoel!

[jaideep bains @stressynomics]

A potential game-changer at NIH. If we want Canada to compete, we need to step it up urgently! @CIHR_IRSC @cafreeland

[Paul W Chrystal @PaulWChrystal]

"Christmasy" zebrafish photoreceptors: actin (red), pcdh15 (green).

Happy Holidays! 🎄

[Paul W Chrystal @PaulWChrystal]

@Ted_Allison @NCLNoel @LanceDoucette

[Paul W Chrystal @PaulWChrystal]

Investigating whether PMEL amyloid dysfunction contributes to pigmentatary glaucoma etiology.

Congratulations to Dr. Elizabeth Hodges, Dr. Mike Walter, Dr. Ted Allison and all of the other contributors for publishing this cool story! Check out the link:

https://t.co/IUIXQchou4

[Paul W Chrystal @PaulWChrystal]

Tragic news that Faye Fantarrow lost her battle against cancer. Such a talented musician, taken long before her time. RIP Faye.

[Paul W Chrystal @PaulWChrystal]

Go check out @SonyaWiden's fantastic new publication in @ScienceMagazine, where they elucidate a mechanism for horizontal gene transfer in animals by ancient virus-like transposons called Mavericks. Such cool science! 👏

[IMBA imbavienna.bsky.social @IMBA_Vienna]

‼️ Breakthrough in evolutionary genetics ‼️

#Virus-like #transposons wage war on the species barrier 🧬🦠🪱🐠🪼 An all-IMBA paper #JustPublished in @ScienceMagazine

Read more ➡️ https://t.co/urXInQ713u

IMBA's Burga Lab @arburga with co-first authors @SonyaWiden & @CampoBes nail down a vector of #HorizontalGeneTransfer (#HGT) in eukaryotes:

The "culprits" are called #Mavericks - Ancient virus-like transposable elements

@viennabiocenter @TrainingVbc @oeaw

Link to the paper in Science ➡️ https://t.co/NX6IxAOC89

More on the Burga Lab's research ➡️ https://t.co/6YKmA5cXK0

Congratulations to all authors: Sonya Widen, Israel Campo Bes, Alevtina Koreshova, Pinelopi Pliota, Daniel Krogull & Alejandro Burga on this groundbreaking work 🎉🎊