Just like people, T cells get exhausted. Taking a break helps!
Here, the authors developed a SNIP CAR - “a protease-based platform for regulating CAR activity using an FDA-approved small molecule”, which showed diminished T cell exhaustion https://t.co/fQ26CGLQZ9
#Immunotherapy
How can regulatory T cells (Tregs) be depleted in cancer?
In this recent paper in @ScienceTM, the authors show how dual targeting of CTLA4 and CD47 on Tregs is effective. https://t.co/1CD2bOfpdi
#AcademicTwitter#Immunotherapy@UTSWNews
What’s happening with CAR-T cells and beyond in cancer?
This nice review summarizes recent advances and efforts to leverage T cells and NK cells. https://t.co/eTLJDclkMr
#Immunotherapy#AcademicTwitter
Can pre-treatment with targeted therapy influence response to subsequent immunotherapy?
Here, they show that "when tumors relapse after anti-MAPK targeted therapy, they are cross-resistant to immunotherapies". https://t.co/n2nFdq2xiZ
#Immunotherapy@NatureCancer
Can immunotherapy provide long-term responses?
Median survival (months) for metastatic melanoma was reported at ASCO for:
CTLA4 + PD1 👉 72.1
PD1 👉 36.9
CTLA4 👉 19.9
#AcademicTwitter#cancer#Immunotherapy@ASCOPost
https://t.co/t2HOJWev1T
Predicting response to immunotherapy is important, but what’s a good marker?
Here they show how TCR clonality of tumor-infiltrating T cells predict anti-PD1 efficacy: https://t.co/DY4zOXAb3f
#AcademicTwitter#cancer#immunotherapy@NatureComms
Does tumor location/tissue site matter?
Here they show how the same tumor cell line display different take rates, immune infiltration, and response to immunotherapy depending on where the tumor grows. https://t.co/5NsejiTv6V
#AcademicTwitter#cancer#Immunotherapy@CIR_AACR
How do tumor cells survive in the circulation?
This recent paper highlights the importance of CCL5 as a mediator of immune evasion. https://t.co/f4mnpGD6dw
#AcademicTwitter#cancer@NatureComms
Who will respond to immunotherapy?
This recent paper suggests that the tumor microenvironment falls into 4 categories and can predict therapeutic response: https://t.co/bQnkt6t0zn #AcademicTwitter@MDAndersonNews@BostonGeneCorp
Cool new finding and beautiful images when researchers identify "a link between sensory neurons activation and the immune system". #AcademicTwitter#phdchat
https://t.co/w3URD2RKG3
Repurposing of drugs for cancer is already a popular strategy. Should all drugs, within reason, that have passed toxicity studies in any indication, be tested in preclinical models of cancer in a high-throughput manner? #AcademicTwitter
It really hits me hard seeing young people die in cancer. Moments of feeling hopeless is exchanged with motivation. Motivation to do better, to contribute to better therapies.
What's your motivation? #AcademicTwitter#cancer#phdchat#beatcancer