@bryan_johnson Check out @RenegadeRes (headed by two lady scientists @tessfalor and @IsabelRamirezRD). They're not selling health products, but doing DIY research into chronic, disabling illnesses.
If you need an explicitly woman's health angle, many of these impact women 2x often as men.
Looking at how #AI reasoning attempts to identify causal mechanisms for #MECFS is mind blowing. (Please note, this is just an example of the process and should not be considered actual results. Content should be evaluated by experts)
1) There's an interesting lead in the ME/CFS genetic data: the eccentric medium spiny neuron (eMSN), a cell type in the brain discovered only a couple of years ago.
All based on preliminary findings, but the data looks rather interesting.
Epstein-Barr virus stays hidden in our immune systems, only to reactivate decades later. New research could point to a solution.
The full story: https://t.co/7lNYSSqnhk
"When you start treating hypermobility as the fifth vital sign, [the list of differentials] completely changes."
--------------
"You know what's wild, as a GI doctor, there was things I were taught in fellowship that I would never see in my career, Median Arcuate Ligament Syndrome (MALS), Superior Mesenteric Artery Syndrome, Retrograde Cricopharyngeus Dysfunction (R-CPD), are zero [incidence]. Really, really rare, but once you start treating people with hypermobility, you realize that they aren't that rare anymore. In fact, they are quite common, and it completely changes the way you think.
In general, when we think "peptic ulcer disease", we think "h pylori". When we hear "bloating", we think "celiac disease, lactose tolerance." However, when treating hypermobility, the menu completely changes. You are thinking, "structural instability, motility issues, vascular compression,."
So yes, in general, these conditions are rare, but not in people with hypermobility, which makes me think we don't have a rare disease problem, we have a pattern recognition problem."
Men's Health: Millions of People Live With Long COVID. This Researcher Is on a Mission to Find a Cure
6 years ago, Dr. Michael Peluso & his team launched a first-of-its-kind long COVID tissue bank & have been working to understand the disease ever since
https://t.co/J3CpDtHdSB
International Online Conference:
Long COVID, ME/CFS and Debilitating Diseases 2026.
Presentation:
DIAGNOSIS AND TREATMENTS ETIOLOGICAL (Microbiological)
OF LONG COVID AND ME/CFS
Clinical Experience and Case Reporting.
View PPT at: https://t.co/rnNaje2eGd
We present the latest information regarding the diagnosis of root causes and treatments for:
LONG COVID
POST-VACCINATION SYNDROME (PVS)
ME/CFS
OTHER DEBILITATING DISEASES
We reiterate that the root causes of acquired diseases are environmental or external agents other than the human being, such as microorganisms, toxins, drugs, allergens, etc.
Reactions, immune response, microclots, and acquired (non-genetic) dysfunctions (mitochondrial, organic) are always effects or consequences of the action of triggering etiological agents (environmental or external agents).
Only by performing a correct etiological diagnosis can the etiological treatment that will achieve the patient's recovery be carried out.
Versión en español disponible en:
https://t.co/PAFKwm0Dad
Fascinating new research from @PlzSolveCFS: What is going on with T cells in Long COVID and ME/CFS? 🤔👇
In this talk, researchers
Dr. Liisa Selin, Dr. Ayano Kohlgruber, and Dr. Roshan Kumar discuss their newest work, arguing that dysfunctional T-cells are driving MECFS and Long COVID.
They examined the CD8+ T cells of patients with these diseases, and found signs of clonal expansion - which only happens when the immune system is chronically exposed to an antigen. 🦠
Clonal expansion can happen in response to a foreign antigen (such as a virus or bacteria), however it can also happen in autoimmunity, where the immune system has accidentally recognized part of the person's own body as "foreign."
They also identified signs of exhaustion in these T cells- meaning that they're becoming worn out trying to fight these antigens, whether they're foreign (as in the case of chronic infection) or self-antigens (as in autoimmunity).
In MECFS and LC patients, they found their CD8 tells were able to produce much lower levels of Interferon-gamma and TNF-a compared to healthy controls.🧪
Previously, Dr. Selin and other researchers had studied an experimental, nebulized treatment called Inspiritol (unfortunately it is not available to patients at this time).
In this new work, the team tested Inspiritol's effects on these exhausted T cells in-vitro, and found it was able to greatly improve the cells' function.
**Other Chronic Pathogens**
Dr. Selin explains that once you have the overactivation and subsequent exhaustion of the CD8+ T cells, it impairs the immune system's ability to keep other chronic pathogens that may be in the person's body under control. This is why patients with these diseases may have a reactivation of herpesviruses such as EBV, CMV, HHV-6, enteroviruses, tick-borne illnesses, and more.🦠
**Identifying T cell Targets**
In the future stage of the work, this team will use technology developed by Dr. Kumar and his company that seeks to identify exactly which pathogens these T-cells are targeting.
Knowing the cause of this abnormal clonal exhaustion will help us to understand exactly why this process is occurring, shedding light on the underlying cause of LC and MECFS.
✨It's pretty exciting to see these advances occurring! Although it may not always seem like it, we get closer to the answers every day!✨
1/
@doc4care@tessfalor@MVGutierrezMD Recently, when experiencing breathing issues and slight chest uncomfortableness, I have gone for leg compression and found it helps clears things up.
So excited to be at the @JohnsHopkinsSPH Tickborne diseases conference! Our live capillaroscopy demo tour continues at JHU!!! Check out a mid-end and high-end capillaroscope with me and see how easy it is to image microvasculature and even the immune cells as they zip through!
Sometimes anal BOTOX is needed to relax the sphincters.
In severe cases loop ileostomy may be the only feasible option.
So just remember. Severe diarrhoea does not always (and usually isn’t) due to fast transit.
The vagus nerve controls more than digestion. It controls five systems appearing unrelated on paper but tracing to one trunk. When it is injured post-viral, you end up with five specialists each treating a fragment of the same problem.
📢Tomorrow!
Webinar: Dr. Liisa Selin (@SelinLab), Dr. Ayano Kohlgruber, & Dr. Roshan Kumar (@hifibio) will discuss "The Discovery of Target Antigens for Dysfunctional T Cells in #MECFS & Long COVID."
Tuesday, 4/28 @ 3 pm PT/ 6 pm ET.
Register:
https://t.co/ORUpaKBl52
This is an incredible $10M donation to our PolyBio Long COVID Cure Initiative (LCCI) Program. Funds are from the Park-Pagliuca Fund: a philanthropic collaboration between the families of Todd Park & Steve Pagliuca, each of whom have family members impacted by Long COVID
NIH are launching a phase 1 trial of Cancer drug Keytruda for Long Covid.
It works by blocking the PD-1 receptor on T cells which releases the brake and reinvigorates them, boosting the immune systems ability to clear viral reservoirs
https://t.co/XeDSSPmyVx