Isabel Burnett | Renegade Research

CEO & founding member Renegade Research, Co-founder Renegade Medical Coaching, Director Remissionbiome Decentralized research/care @renegaderes @remissionbiome

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

My son published the first book of a series he is writing. IF you can, please support him for yourself (if you like the genre) or to gift to someone.

https://t.co/LWXq5VoyRt

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

A friend is facing an unimaginable challenge, living in their car after losing their home. Their car broke down, adding to the challenge. Every dollar raised will help repair their vehicle and provide a safer place to stay. Please consider donating or sharing to support them in this tough time. Every bit helps! https://t.co/kjCYlzZUfl

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

@_katetolo @bryan_johnson This is amazing. Lets compare to chronically ill females in conditions affecting mostly women 🙋🏾‍♀️

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

Curious if anyone is taking nucynta (tapentadol) for longer than a couple of weeks, if it was carefully titrated and what effect it is having on ME symptoms

[Resia Pretorius @resiapretorius]

1/8) We are excited that our paper has been published with lead author @maxinewaters250 and @dbkell

In this study, we investigate Post-Vaccination/Post-Infection Syndrome (PV/PIS) and its underlying biology.
🔗 https://t.co/RjREJW9Jef

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

@StevenShorrock @BenedicteLene The additional challenge to this is that between the 20-50% loss there is a lot of daily variability and even variability within the same day for many of us.

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

@gymrat_bookworm @AndrewG76201347 @NovaSupport

[Ror Preston @RorPreston]

ME/CFS shows the highest impact on family members’ and partners' quality of life among conditions so far studied using the FROM-16 questionnaire

[Debbie @ Genetic Lifehacks @GeneticLifehack]

There's a tiny ion channel in your body that's involved in migraines, chronic fatigue, long Covid, and pain sensitivity — and most people have never heard of it.

Meet TRPM3. 🧬

TRPM3 is a calcium ion channel that sits on your nerve cells and acts like a heat alarm. When it detects high heat — or certain neurohormones — it opens up and lets calcium flood in, which signals pain in sensory neurons.

But TRPM3 doesn't just handle heat. It's also involved in:
- Migraine signaling
- Insulin release from the pancreas
- Blood vessel constriction
- Immune cell function
- Glutamate balance in the brain

One channel. A lot of effects.

The migraine connection is fascinating — especially for women.

Progesterone suppresses TRPM3. When it drops during your cycle, TRPM3 becomes more active and triggers CGRP release in the trigeminal nerve.

CGRP is a key driver of migraines. This is the biological chain.

Here's where it gets really interesting: #MECFS

Studies show that ME/CFS patients have reduced TRPM3 function on natural killer (NK) cells.

NK cells need calcium influx through TRPM3 to release the granules that kill virus-infected cells. Less TRPM3 = blunted immune response. TRPM3 also affects blood pressure response and glutamate/GABA homeostasis.

The same TRPM3 dysfunction is now showing up in #longCovid patients too.

Fatigue, brain fog, post-exertional malaise, pain — symptoms that overlap heavily with ME/CFS.

Here's the hopeful part: a 2025 study showed that low-dose naltrexone (LDN) can restore TRPM3 function in long Covid and ME/CFS patient cells — within 24 hours.

LDN blocks the mu-opioid receptor, which normally suppresses TRPM3. Remove the block, restore the function.

Your genetics also matter here. Multiple variants in the TRPM3 gene are associated with increased ME/CFS risk. Others affect migraine susceptibility and pain sensitivity.

Check out the full article for all the details, look at your TRPM3 variants, and see the solutions (natural and medications) that interact with TRPM3.

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

Yesterday roundtable also discussed the GI benefits seen clinically

[Massimo @Rainmaker1973]

Ozempic activates a 'repair mode' in cartilage cells, boosting joint thickness by 17% and potentially reducing the need for invasive surgeries.

For years, experts assumed that the joint pain relief seen with Ozempic was mainly due to weight loss. A landmark 2026 study has challenged that view. Researchers from the Shenzhen Institutes of Advanced Technology discovered that semaglutide—the active ingredient in Ozempic—acts directly on cartilage cells (chondrocytes) to promote regeneration.

By reprogramming the cells' energy metabolism (shifting from inefficient glycolysis toward more efficient oxidative phosphorylation via the GLP-1R-AMPK-PFKFB3 pathway), the drug helps trigger a restorative process that rebuilds the protective cartilage cushioning in joints—tissue long thought to be irreplaceable once lost.

The results are striking. In a small pilot clinical study, advanced MRI scans showed an average 17% increase in cartilage thickness after six months of treatment, along with signs of new cartilage growth in weight-bearing areas. Patients also experienced reduced pain and improved joint function.

This breakthrough points to a new way of treating osteoarthritis: not just managing symptoms, but addressing the underlying structural damage. While larger trials are still needed, semaglutide is emerging as a promising option that could help millions of people avoid or delay joint replacement surgeries and restore mobility through direct cellular repair—independent of its well-known weight-loss effects.

[Qin, H., Yu, J., Yu, H., et al. (2026). Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism. Cell Metabolism, 38(3), 582–597.e6. DOI: 10.1016/j.cmet.2026.01.008]

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

Just posted today's roundtable with Dr Spiritos.

[Renegade Research @RenegadeRes]

The recording of today's roundtable is now posted to our YT channel
https://t.co/z0jz7jtwcn

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

This is today. Come have fun with us. If you can’t join us the recording will be up on YT after. Subscribe to our YT channel to get notifications when recordings are uploaded.

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

I am very excited about this roundtable.
I first heard Dr Spiritos on the @bendy_bodies podcast and called @NovaSupport super excited and she reached out and made it happen.

Please invite your clinicians as this provider is a great example of what can be done!

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

@Naomi_D_Harvey I’m an over achiever. Got it at 7 and my early 20s were hell, Then another hell in my early 30s. The excelling nobody asked for 🤷🏽‍♀️

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

I am very excited about this roundtable.
I first heard Dr Spiritos on the @bendy_bodies podcast and called @NovaSupport super excited and she reached out and made it happen.

Please invite your clinicians as this provider is a great example of what can be done!

[Renegade Research @RenegadeRes]

We welcome you to join us on Friday, March 27 at 1 pm ET (US) for a Clinician's Roundtable with neurogastroenterologist Dr. Zac Spiritos

He will be discussing the Gastrointestinal-Neuroimmune Axis & the Role of Histamine and Mast Cells

Registration link below with info on Dr. Spiritos' work 🧵

[Arf-PEM-Jansen 🪫 @dokter_Arf]

📊 Poll Glucocorticoids (Steroids) 💊
Your #MECFS #LongCovid Experience with Prednison, Dexamethasone, Hydrocortisone Methylprednison, etc.

1) What is your Overall experience with Glucocorticoids (Steroids) ?

(*More Questions below AND please add yr Comments👇🏻)
(1/7)

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

@candlelovers12 @Naomi_D_Harvey @EricTopol @NatureMedicine Vets 🫶🏽

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

Dominican team draws first blood @WBCBaseball
🎊🥎🎊

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

This great roundtable is now posted to our YT channel

[Renegade Research @RenegadeRes]

Recording of this presentation is now posted to our YT channel https://t.co/3IbiElqu6J

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

@ValerieJay16 @EricTopol @NatureMedicine It should be done during, not just after

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

@Naomi_D_Harvey @candlelovers12 @EricTopol @NatureMedicine I don’t understand how knowing what we know about the microbiome, they still rx abx w/o a plan to restore & letting them get wiped out during the course of trx

[Isabel Burnett | Renegade Research @IsabelRamirezRD]

@MaryGR65 @Naomi_D_Harvey Yes, I have taken it for about 2 years some of that time intermittently. Tagging @joshual_tm to link to the info on BF