John Mark Pero

Founder @
Longevity, peptides, and a life well-lived.

[John Mark Pero @peronormal]

Semaglutide is the 'Model T' of GLPs. The first mass-market success of a new era.

The narrowing differences between new GLP options will be like discussing horsepower and steering, while today the real unlock is just having a car.

[Andrew D. Huberman, Ph.D. @hubermanlab]

I predict peptides will change everything re public health discourse for health & disease. B/c they’re closer to medications (in many cases actual medications!) than supplements but they entered the picture in supplement-like fashion. HRT went the other direction. Get educated.

[John Mark Pero @peronormal]

peptides summer 2026 is coming.

you'll start seeing it in coachella pictures in 2wk

[Hims House @himshouse]

🚨 BREAKING: GOOGLE SEARCH INTEREST FOR "PEPTIDES" HAS SURPASSED "OZEMPIC"

h/t @edwrdmoreno

$HIMS $LLY $NVO

[Kamal Ravikant @kamalravikant]

There is a quiet health revolution happening. To see it, join peptide groups on Telegram and Discord. You'll find normal people sourcing peptides, vetting suppliers, group testing, and sharing their results. To put it simply, helping each other.

There are mothers who know more about peptides than your tech/hollywood bros ever will.

It's decentralized. It's grandparents teaching each other crypto to buy peptides from China. It's real people having real results.

They're done with the system that keeps them sick and overmedicated.

It's honestly inspiring to watch.

[John Mark Pero @peronormal]

When everybody's on peptides, nobody's on peptides..

(the health & aesthetics bar just raises)

[John Mark Pero @peronormal]

The smartest, healthiest & hottest people you know are all injecting themselves with peptides.

[John Mark Pero @peronormal]

Peptides are to medicine what Crypto is to finance.

Massive upside. Murky regulation. Personal sovereignty.

I'm here for it.

[John Mark Pero @peronormal]

Current Barriers:
- lack of clinical data in healthy populations
- stigma / education
- access (many can’t get prescribed under 27BMI, affordable compounded GLP1s could largely go away this year)

[John Mark Pero @peronormal]

GLP-1 drugs at low doses will become mainstream for wellness optimizers.

Inflammation reduction, metabolic flexibility, lean mass recomp and neuroprotection.

Diabetes + weight loss is the tip of the spear.

[John Mark Pero @peronormal]

@pranav_email design

[John Mark Pero @peronormal]

@therealarkin @pitdesi @TurnerNovak sample size could be bigger yes- google says 13 million americans have tried glp-1, if 20% stay on that's almost 1% of the population taking them. as someone who manages glp-1 patients i think that number might be higher. our patients are definitely making healthier food choices

[John Mark Pero @peronormal]

GLP-1s are lifesavers. We need to give people things that work now while ALSO working to improve the food environment. It's both, not either/or.

[Sheel Mohnot @pitdesi]

People who take GLP-1s reduce their grocery spending by 11%, but they spend 27% MORE on lean proteins and 52% LESS on junk snacks.

[John Mark Pero @peronormal]

@helloitsdrew_ feature

[John Mark Pero @peronormal]

biohackers law -
the more you brag about your biological age the less you look it

[John Mark Pero @peronormal]

@YoussefEcom Send

[John Mark Pero @peronormal]

@landforce I'll DM you where I get it. It's powerful and works.

[John Mark Pero @peronormal]

@landforce I keep a vial of Thymosin Alpha 1 peptide in my freezer and whenever I feel immune compromised take it. Powerful immune modulator and good for fighting off bugs. The biohacky/peptide community loves this stuff too: https://t.co/NtPy2jlXMh.

[John Mark Pero @peronormal]

@itmebenjamin Thanks for sharing. Excited for and rooting for you in whatever’s next.

[John Mark Pero @peronormal]

More here:
https://t.co/r6BnaxjIgV

[John Mark Pero @peronormal]

FDA about to ban peptides?

They just issued a directive that bans compounding pharmacies from making some of the most widely prescribed peptides.

These are safe and cheap alternatives to gnarly big pharma drugs.

Follow the money and perverse incentives. Sad to see.